Risk Factors and Outcomes of Hepatitis A in Children
Risk Factors, Clinical Course and Predictors of Outcome in Children With Hepatitis A Infection Admitted in Assiut University Children Hospital
This prospective observational study aims to evaluate the risk factors, clinical course, and outcomes among children with acute hepatitis A infection admitted to Assiut University Children Hospital.
研究概览
详细说明
Hepatitis A virus infection is a common cause of acute hepatitis in children in Egypt. While most cases recover completely, some children may develop complications such as prolonged cholestasis, acute liver failure, or hepatic encephalopathy.
This observational study will include children aged 1 month to 18 years with confirmed acute hepatitis A infection (positive Anti-HAV IgM). Patients will be followed during their hospital stay to assess clinical course and outcomes.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Nada A Fouad, Resident
- 电话号码：+20 11 18762071
- 邮箱：Nada.17289945@med.aun.edu.eg
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Children with confirmed acute hepatitis A infection admitted to or presenting at Assiut University Children Hospital.
描述
Inclusion Criteria:
- Age 1 month to 18 years
- Confirmed acute hepatitis A infection by positive Anti-HAV IgM
- Written informed consent from parents or legal guardians
Exclusion Criteria:
- - Co-infection with hepatitis B, hepatitis C, or hepatitis E
- Chronic liver diseases (autoimmune hepatitis, Wilson disease, metabolic liver diseases)
学习计划
研究是如何设计的？
设计细节
- 观测模型：COHORT
- 时间观点：PROSPECTIVE
队列和干预
团体/队列 |
|---|
|
Single cohort: Children with acute hepatitis A
Children aged 1 month to 18 years with confirmed acute hepatitis A infection who will be followed during hospital stay to assess clinical course and outcomes. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Proportion of children with unfavorable outcome
大体时间：Baseline
|
Proportion of children who develop one or more of the following during hospital stay: acute liver failure, hepatic encephalopathy, acute kidney injury, ICU admission, prolonged hospital stay (>7 days), or death. |
Baseline
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Proportion of children with acute liver failure
大体时间：Baseline
|
Proportion of children who develop acute liver failure during hospital stay. |
Baseline
|
|
Proportion of children with hepatic encephalopathy
大体时间：Baseline
|
Proportion of children who develop hepatic encephalopathy (any West Haven grade) during hospital stay. |
Baseline
|
|
Mean duration of hospital stay
大体时间：Baseline
|
Mean number of days of hospitalization. |
Baseline
|
|
Proportion of children requiring ICU admission
大体时间：Baseline
|
Proportion of children who require intensive care unit admission. |
Baseline
|
|
Mortality rate
大体时间：Baseline
|
Proportion of children who die during hospital stay. |
Baseline
|
合作者和调查者
调查人员
- 学习椅：Ahlam B Ali, prof、Pediatrics Department, Assiut University Hospitals
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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