Risk Factors and Outcomes of Hepatitis A in Children
Risk Factors, Clinical Course and Predictors of Outcome in Children With Hepatitis A Infection Admitted in Assiut University Children Hospital
This prospective observational study aims to evaluate the risk factors, clinical course, and outcomes among children with acute hepatitis A infection admitted to Assiut University Children Hospital.
Studieoversigt
Status
Betingelser
Detaljeret beskrivelse
Hepatitis A virus infection is a common cause of acute hepatitis in children in Egypt. While most cases recover completely, some children may develop complications such as prolonged cholestasis, acute liver failure, or hepatic encephalopathy.
This observational study will include children aged 1 month to 18 years with confirmed acute hepatitis A infection (positive Anti-HAV IgM). Patients will be followed during their hospital stay to assess clinical course and outcomes.
Undersøgelsestype
Tilmelding (Anslået)
Kontakter og lokationer
Studiekontakt
- Navn: Nada A Fouad, Resident
- Telefonnummer: +20 11 18762071
- E-mail: Nada.17289945@med.aun.edu.eg
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Children with confirmed acute hepatitis A infection admitted to or presenting at Assiut University Children Hospital.
Beskrivelse
Inclusion Criteria:
- Age 1 month to 18 years
- Confirmed acute hepatitis A infection by positive Anti-HAV IgM
- Written informed consent from parents or legal guardians
Exclusion Criteria:
- - Co-infection with hepatitis B, hepatitis C, or hepatitis E
- Chronic liver diseases (autoimmune hepatitis, Wilson disease, metabolic liver diseases)
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: COHORT
- Tidsperspektiver: PROSPECTIVE
Kohorter og interventioner
Gruppe / kohorte |
|---|
|
Single cohort: Children with acute hepatitis A
Children aged 1 month to 18 years with confirmed acute hepatitis A infection who will be followed during hospital stay to assess clinical course and outcomes. |
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Proportion of children with unfavorable outcome
Tidsramme: Baseline
|
Proportion of children who develop one or more of the following during hospital stay: acute liver failure, hepatic encephalopathy, acute kidney injury, ICU admission, prolonged hospital stay (>7 days), or death. |
Baseline
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Proportion of children with acute liver failure
Tidsramme: Baseline
|
Proportion of children who develop acute liver failure during hospital stay. |
Baseline
|
|
Proportion of children with hepatic encephalopathy
Tidsramme: Baseline
|
Proportion of children who develop hepatic encephalopathy (any West Haven grade) during hospital stay. |
Baseline
|
|
Mean duration of hospital stay
Tidsramme: Baseline
|
Mean number of days of hospitalization. |
Baseline
|
|
Proportion of children requiring ICU admission
Tidsramme: Baseline
|
Proportion of children who require intensive care unit admission. |
Baseline
|
|
Mortality rate
Tidsramme: Baseline
|
Proportion of children who die during hospital stay. |
Baseline
|
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Studiestol: Ahlam B Ali, prof, Pediatrics Department, Assiut University Hospitals
Datoer for undersøgelser
Studer store datoer
Studiestart (Anslået)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- HAV-Children-Assiut-2026
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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