Skipping Breakfast Before Exercise Creates a More Negative 24-hour Energy Balance: A Randomized Controlled Trial in Healthy Physically Active Young Men

Robert M Edinburgh, Aaron Hengist, Harry A Smith, Rebecca L Travers, James A Betts, Dylan Thompson, Jean-Philippe Walhin, Gareth A Wallis, D Lee Hamilton, Emma J Stevenson, Kevin D Tipton, Javier T Gonzalez, Robert M Edinburgh, Aaron Hengist, Harry A Smith, Rebecca L Travers, James A Betts, Dylan Thompson, Jean-Philippe Walhin, Gareth A Wallis, D Lee Hamilton, Emma J Stevenson, Kevin D Tipton, Javier T Gonzalez

Abstract

Background: At rest, omission of breakfast lowers daily energy intake, but also lowers energy expenditure, attenuating any effect on energy balance. The effect of breakfast omission on energy balance when exercise is prescribed is unclear.

Objectives: The aim of this study was to assess the effect on 24-h energy balance of omitting compared with consuming breakfast prior to exercise.

Methods: Twelve healthy physically active young men (age 23 ± 3 y, body mass index 23.6 ± 2.0 kg/m2) completed 3 trials in a randomized order (separated by >1 week): a breakfast of oats and milk (431 kcal; 65 g carbohydrate, 11 g fat, 19 g protein) followed by rest (BR); breakfast before exercise (BE; 60 min cycling at 50 % peak power output); and overnight fasting before exercise (FE). The 24-h energy intake was calculated based on the food consumed for breakfast, followed by an ad libitum lunch, snacks, and dinner. Indirect calorimetry with heart-rate accelerometry was used to measure substrate utilization and 24-h energy expenditure. A [6,6-2H2]glucose infusion was used to investigate tissue-specific carbohydrate utilization.

Results: The 24-h energy balance was -400 kcal (normalized 95% CI: -230, -571 kcal) for the FE trial; this was significantly lower than both the BR trial (492 kcal; normalized 95% CI: 332, 652 kcal) and the BE trial (7 kcal; normalized 95% CI: -153, 177 kcal; both P < 0.01 compared with FE). Plasma glucose utilization in FE (mainly representing liver glucose utilization) was positively correlated with energy intake compensation at lunch (r = 0.62, P = 0.03), suggesting liver carbohydrate plays a role in postexercise energy-balance regulation.

Conclusions: Neither exercise energy expenditure nor restricted energy intake via breakfast omission were completely compensated for postexercise. In healthy men, pre-exercise breakfast omission creates a more negative daily energy balance and could therefore be a useful strategy to induce a short-term energy deficit. This trial was registered at clinicaltrials.gov as NCT02258399.

Keywords: breakfast; carbohydrate; exercise; energy balance; fasting; metabolism; physical activity; substrate metabolism.

Copyright © American Society for Nutrition 2019.

Figures

FIGURE 1
FIGURE 1
Schematic. Twelve healthy physically active young men completed 3 trials in randomly assigned order: breakfast followed by rest (BR), breakfast followed by exercise (BE), or overnight fasting followed by exercise (FE). Daily energy intake was determined based on an ad libitum lunch, snacks, and dinner meals. Indirect calorimetry (within-lab) and heart-rate accelerometry (free-living) were used to assess substrate use and daily energy expenditure. A [6,6-2H2]glucose infusion was used to assess tissue-specific carbohydrate utilization.
FIGURE 2
FIGURE 2
Daily energy intake (A) and energy expenditure (B). Data are means ± normalized (n) 95% CIs for n = 12 (9 for free-living energy expenditure) healthy young men. In panel A, "a" represents a difference in free-living energy intake with breakfast rest and breakfast exercise with P < 0.05, and "b" a difference in lunch energy intake in breakfast exercise compared with fasted exercise with P < 0.05. In panel B, "a" represents a difference for within-lab energy expenditure with breakfast rest and both exercise trials with P < 0.05.
FIGURE 3
FIGURE 3
The plasma glucose rate of disappearance (Rd) (A), muscle glycogen utilization (B), whole-body lipid utilization (C), and energy expenditure (D) during fasted exercise compared with lunch energy intake compensation (lunch energy intake after fasted exercise minus lunch energy intake after rest) normalized to resting metabolic rate (RMR). Data are Pearson's r. n = 12 healthy young men.
FIGURE 4
FIGURE 4
Within-lab (A) and daily energy balance (B). Data are means ± normalized (n) 95% CIs for n = 12 (9 for daily energy balance) healthy young men. In panel A, "a" represents a difference in CHO balance between breakfast rest and breakfast exercise with P < 0.05, and "b" a difference in FAT balance for breakfast exercise and fasted exercise with P < 0.05. PRO, protein; CHO,  carbohydrate.
FIGURE 5
FIGURE 5
Plasma leptin (A) and FGF-21 (B) concentrations. Data are means ± normalized (n) 95% CIs for n = 12 healthy young men. EX, exercise; FGF-21, fibroblast growth factor 21; OGTT, oral glucose tolerance test.

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Source: PubMed

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