Bladder Cancer Case Control Study of Arsenic in Water
March 22, 2006 updated by: National Institute of Environmental Health Sciences (NIEHS)
This study is examining the relationship between ingested arsenic and bladder cancer in two areas of California where a large percentage of the population was exposed to drinking water containing arsenic at low to moderate levels.
Study Overview
Status
Completed
Conditions
Detailed Description
Water supplies in many parts of the world contain naturally occurring arsenic.
Previous studies have shown that arsenic at high doses can cause cancer of the bladder.
The risk at lower doses is unknown.
This study is examining the relationship between ingested arsenic and bladder cancer in central Nevada and Kings County, California, two areas where a large percentage of the population was exposed to drinking water containing arsenic at low to moderate levels.
Approximately 200 people with bladder cancer and 400 people without bladder cancer will be included.
Subjects are interviewed by telephone about past residences, occupations, diet, drinking water consumption, and other lifestyle factors.
Arsenic measurements in well water have been collected from the appropriate state agencies and are being matched with residences and drinking water consumption rates to estimate lifetime arsenic exposures for each subject.
People with bladder cancer will then be compared to those without to see if people with cancer were more likely to have lived in areas with arsenic in their drinking water.
Study Type
Observational
Enrollment
600
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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California
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Berkeley, California, United States, 94720
- Allan Smith Research Office
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 85 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Cases must meet the following criteria:
- Diagnosed with primary bladder cancer from January 1, 1997 until December 31, 2000.
- Live in the following counties at the time of diagnosis: Churchill, Lyon, Mineral, Storey, Douglas, Carson City, Nevada, and Kings County, California
- Ages 20-85 at the time of diagnosis.
Controls will be matched to cases based on gender and five year age groups.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 1997
Study Completion
July 1, 2001
Study Registration Dates
First Submitted
February 22, 2001
First Submitted That Met QC Criteria
February 23, 2001
First Posted (Estimate)
February 26, 2001
Study Record Updates
Last Update Posted (Estimate)
March 23, 2006
Last Update Submitted That Met QC Criteria
March 22, 2006
Last Verified
March 1, 2006
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 7459-CP-001
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.