Parkinson's Research: The Organized Genetics Initiative (PROGENI)

February 15, 2011 updated by: Indiana University School of Medicine

Parkinson's Disease Collaborative Study of Genetic Linkage

The purpose of this trial is to study genetic and other risk factors that may be important in the development of Parkinson's disease.

Study Overview

Status

Completed

Conditions

Detailed Description

The The Parkinson's Research: The Organized Genetics Initiative, also known as PROGENI, is a multi-center study involving 2000 people throughout North America who are affected, or possibly affected, with Parkinson's disease (PD). The goal of the initiative is to study the genetic and other risk factors which may be important in the development of PD.

In order to better understand the genetic factors leading to PD, researchers will study families having 2 or more members diagnosed with PD. Using DNA samples from each participant, researchers hope to identify genes that may cause a person to be at higher risk for developing PD.

Each participant in the study will be asked to complete a family history questionnaire, providing information about the history of PD in the family. Participants also will be asked to discuss the symptoms they have experienced and their responses to PD medications. This information will be used by study personnel to determine further eligibility for the study. Those eligible for further participation will be asked to undergo a study visit at the site closest to their residence, during which they will be asked to complete questionnaires regarding PD symptoms, medical history, places of residence, occupations, mood, mental status, and activity level. A blood sample will be drawn for DNA extraction. The study visit will take about 2 hours.

Study Type

Observational

Enrollment (Anticipated)

1800

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
    • Alberta
      • Edmonton, Alberta, Canada
        • University of Alberta
    • Ontario
      • London, Ontario, Canada
        • London Health Sciences Center
      • Ottawa, Ontario, Canada
        • Ottawa Civic Hospital
      • Toronto, Ontario, Canada
        • Toronto Western Hospital
    • Quebec
      • Montreal, Quebec, Canada
        • Hotel-Dieu Hospital-CHUM
  • Puerto Rico
      • San Juan, Puerto Rico
        • University of Puerto Rico School of Medicine
  • United States
    • Arizona
      • Phoenix, Arizona, United States, 85013
        • Barrow Neurological Institute
    • California
      • Fountain Valley, California, United States, 92708
        • Parkinson's & Movement Disorder Institute
      • Irvine, California, United States, 92612
        • University of California Irvine
      • Oxnard, California, United States
        • Pacific Neuroscience Medical Group, Inc
      • San Diego, California, United States, 92101
        • University of California San Diego
      • San Francisco, California, United States, 94143
        • University of California San Francisco
    • Colorado
      • Denver, Colorado, United States, 80262
        • University of Colorado Health Sciences Center
      • Englewood, Colorado, United States, 80113
        • Colorado Neurological Institute
    • Connecticut
      • New Haven, Connecticut, United States, 06510
        • Institute for Neurodegenerative Disorders
    • Florida
      • Boca Raton, Florida, United States
        • Parkinson's Disease & Mmvt Disorders Ctr of Boca Raton
      • Jacksonville, Florida, United States, 32224
        • Mayo Clinic Jacksonville
      • Tampa, Florida, United States, 33620
        • University of South Florida
      • Weston, Florida, United States, 33331
        • Cleveland Clinic Florida
      • Weston, Florida, United States
        • Cleveland Clinic Florida
    • Georgia
      • Augusta, Georgia, United States, 30912
        • Medical College of Georgia
    • Hawaii
      • Honolulu, Hawaii, United States
        • Pacific Health Research Institute
    • Illinois
      • Chicago, Illinois, United States, 60637
        • University of Chicago
      • Chicago, Illinois, United States, 60611
        • Northwestern University Medical School
      • Evanston, Illinois, United States, 60026
        • Evanston Northwestern Healthcare
      • Springfield, Illinois, United States
        • Southern Illinois Univ School of Medicine
    • Indiana
      • Indianapolis, Indiana, United States, 46202
        • Indiana University School of Medicine
    • Iowa
      • Iowa City, Iowa, United States, 52242
        • University of Iowa
    • Kansas
      • Kansas City, Kansas, United States, 66160
        • Kansas University Medical Center
    • Louisiana
      • New Orleans, Louisiana, United States, 70112
        • Oschsner Clinic Foundation
      • Shreveport, Louisiana, United States, 71130
        • LSU Health Sciences Center
    • Maine
      • Scarborough, Maine, United States
        • Port City Neurology, Inc
    • Maryland
      • Baltimore, Maryland, United States, 21201
        • University of Maryland School of Medicine
      • Baltimore, Maryland, United States
        • Johns Hopkins University
    • Massachusetts
      • Boston, Massachusetts, United States, 02215
        • Beth Israel Deaconess Medical Center
      • Boston, Massachusetts, United States, 02115
        • Brigham & Women's Hospital
    • Michigan
      • East Lansing, Michigan, United States
        • Michigan State University
      • Southfield, Michigan, United States
        • Henry Ford Health System
    • Minnesota
      • Minneapolis, Minnesota, United States, 55406
        • University of Minnesota Fairview Univ Med Ctr
    • Missouri
      • St. Louis, Missouri, United States, 63130
        • Washington University
    • New York
      • Albany, New York, United States, 12208
        • Albany Medical College
      • Buffalo, New York, United States
        • University of Buffalo
      • New York, New York, United States, 10003
        • Beth Israel Medical Center
      • New York, New York, United States, 10029
        • Mount Sinai Medical Center
      • New York, New York, United States, 10032
        • Columbia-Presbyterian Medical Center
      • Rochester, New York, United States, 14642
        • University of Rochester Medical Center
    • North Carolina
      • Winston-Salem, North Carolina, United States, 27157
        • Wake Forest University School of Medicine
    • Ohio
      • Cincinnati, Ohio, United States, 45267
        • University of Cincinnati Medical Center
      • Cleveland, Ohio, United States
        • Cleveland Clinic Foundation
      • Columbus, Ohio, United States, 43210
        • Ohio State University
      • Toledo, Ohio, United States, 43614
        • Medical College of Ohio, ,
    • Oregon
      • Portland, Oregon, United States, 97239
        • Oregon Health & Science University
    • Pennsylvania
      • Pittsburg, Pennsylvania, United States
        • University of Pittsburg
    • Rhode Island
      • Warwick, Rhode Island, United States, 02886
        • Neurohealth
    • Tennessee
      • Memphis, Tennessee, United States, 38163
        • University of Tennessee-Health Sciences Center
    • Texas
      • Dallas, Texas, United States, 75390
        • UT Southwestern Medical Center
      • Houston, Texas, United States, 77030
        • Baylor College of Medicine
    • Wisconsin
      • Milwaukee, Wisconsin, United States, 53226
        • Medical College Of Wisconsin

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

families having 2 or more members diagnosed with PD

Description

Inclusion Criteria:

  • To be eligible to participate in this study participants must be diagnosed with or have symptoms of PD. In addition, they must also have a family history of PD in other relatives.

Exclusion Criteria:

  • Subjects cannot have participated in any other genetic research project for Parkinson's disease.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Indiana University School of Medicine

Collaborators

National Institute of Neurological Disorders and Stroke (NINDS)
Children's Hospital Medical Center, Cincinnati
The Parkinson Study Group

Investigators

  • Principal Investigator: Tatiana Foroud, Ph.D., Indiana University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 1998

Study Completion (Actual)

January 1, 2011

Study Registration Dates

First Submitted

June 22, 2004

First Submitted That Met QC Criteria

June 23, 2004

First Posted (Estimate)

June 24, 2004

Study Record Updates

Last Update Posted (Estimate)

February 16, 2011

Last Update Submitted That Met QC Criteria

February 15, 2011

Last Verified

November 1, 2010

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 9703-09
  • R01NS037167 (U.S. NIH Grant/Contract)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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