Skeletal Muscle Dysfunction in Heart Failure

September 8, 2005 updated by: Ullevaal University Hospital

Training and Congestive Heart Failure

Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.

We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment

45

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Norway
      • Oslo, Norway, 0806
        • Recruiting
        • Norwegian School of Sport Sciences
        • Contact:
        • Contact:
        • Sub-Investigator:
          • Jostein Hallen, Professor
      • Oslo, Norway, 0407

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years to 78 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Coronary Heart Failure
  • Ejection fraction <35%
  • NYHA 2-3
  • Spirometry FEV1 > 80%

Exclusion Criteria:

  • Cardiomyopathy
  • Transplantation candidate
  • Active malignancy
  • Restraining skeletal-muscular disease
  • Claudication in legs
  • Hospitalized last 30 days due to acute ischemic episode
  • Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion
  • AMI last 8 weeks prior to inclusion
  • Organized training last 4 months
  • Smoking on daily basis last 4 months
  • Creatinin < 150microliters/liter

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: ECT
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: SINGLE

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ullevaal University Hospital

Collaborators

University of Oslo
The Research Council of Norway
Norwegian School of Sport Sciences
Norwegian Health Association

Investigators

  • Study Chair: Ole M Sejersted, Professor, Institute for Experimental Medical Research, Ullevaal University Hospital
  • Study Director: Per Kristian B Lunde, Post Doc, Institute for Experimental Medical Research, Ullevaal University Hospital
  • Study Director: Ivar Sjaastad, Post Doc, Institute for Experimental Medical Research, Ullevaal University Hospital
  • Study Chair: Jostein Hallen, Professor, Norwegian School of Sport Sciences
  • Principal Investigator: Morten Munkvik, Ph.D student, Institute for Experimental Medical Research, Ullevaal University Hospital
  • Principal Investigator: Tommy A Rehn, Vit.ass., Institute for Experimental Medical Research, Ullevaal University Hospital
  • Principal Investigator: Gunnar S Petersen, Ph.D student, Norwegian School of Sport Sciences

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2005

Study Registration Dates

First Submitted

September 8, 2005

First Submitted That Met QC Criteria

September 8, 2005

First Posted (ESTIMATE)

September 12, 2005

Study Record Updates

Last Update Posted (ESTIMATE)

September 12, 2005

Last Update Submitted That Met QC Criteria

September 8, 2005

Last Verified

September 1, 2005

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • TRUST-001
  • Helse Øst
  • Helse og rehabilitering

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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