Studying the Analgesic Mechanism of the "Cough-trick"

June 8, 2026 updated by: University Medicine Greifswald

Studying the Analgesic Mechanism of the "Cough-trick" - Randomized Crossover Volunteer Study

The aim of the trial is to study the possible mechanism of the pain reducing effect of CT at peripheral venipuncture

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

21

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 35 years (Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  1. Male volunteers aged 20-40 years, height 165-190 cm.
  2. Physical status I according to American Society of Anesthesiologists (ASA) classification.
  3. Straight run of the vein on the dorsum of the non-dominant hand at least 4 cm long and 3 mm thick
  4. No analgesics, anticoagulants and/or antiplatelet agents, sedatives or alcohol

Exclusion Criteria:

  1. History of peripheral neuropathy
  2. Abnormal skin conditions (infection, scars, psoriasis, eczema)
  3. Unsuccessful venipuncture
  4. Inflamed site of VP within 1 week after VP

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: cough-trick
Venipuncture with cough-trick technique
Procedure: Venipuncture with "cough-trick"
No Intervention: without cough trick
Venipuncture without cough-trick technique

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Pain intensity measured on 100 mm Visual Analogue Scale scale (VAS-100) where 0 = no pain and 100 = maximal pain
Time Frame: immediately during venipuncture
immediately during venipuncture

Secondary Outcome Measures

Outcome Measure
Time Frame
Heart rate, beats per minute
Time Frame: 5 min during venipuncture
5 min during venipuncture

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Medicine Greifswald

Investigators

  • Principal Investigator: Taras I. Usichenko, Assistant Professor, Anesthesiology and Intensive Care Medicine Department, Ernst Moritz Arndt University of Greifswald, Germany

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2004

Primary Completion (Actual)

March 30, 2008

Study Completion (Actual)

March 30, 2008

Study Registration Dates

First Submitted

October 5, 2005

First Submitted That Met QC Criteria

October 5, 2005

First Posted (Estimated)

October 6, 2005

Study Record Updates

Last Update Posted (Actual)

June 11, 2026

Last Update Submitted That Met QC Criteria

June 8, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • III UV 82/03

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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