Expression of Steroid Receptors in Endometrium

Expression of Steroid Receptors in Endometrium During the Early Follicular Phase in Stimulated Cycles

Expression of steroid receptors in endometrium during ovarian stimulation.

Study Overview

• Status: Completed
• Conditions: Endometrium

Detailed Description

The purpose of this study is to examine in stimulated cycles a) whether there is a difference in expression of steroid receptors in stroma and glands of endometrium between different days during the follicular phase b)whether there are secretory changes detected by endometrium histology before ovulation c)whether there is an association between expression of steroid receptors in endometrium and exposure to oestradiol and progesterone during the follicular phase.

• Study Type: Observational
• Enrollment (Anticipated): 30

Contacts and Locations

Study Locations

• Greece
  • Thessaloniki, Greece, 56429
    • Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 39 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Probability Sample

Study Population

infertile women

Description

Inclusion Criteria:

• Treatment by IUI,
• BMI:18-29KGR/M2,
• No previous ovarian surgery,
• Normal hysterosalpingography,
• Estradiol < 80pg/ml and progesterone < 1.6ng/ml on day 2 of the cycle

Exclusion Criteria:

• Endometriosis,
• Severe male factor

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Steroid receptors expression in endometrium during early follicular phase	3 months

Secondary Outcome Measures

Outcome Measure	Time Frame
In which day:day o+2, day 0+4 or day HCG	1 month

Collaborators and Investigators

• Sponsor: Aristotle University Of Thessaloniki
• Investigators: Study Director: Basil C Tarlatzis, MD,PhD, Unit of Human Reproduction, 1st Department of Obst & Gyn, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece

Publications and helpful links

General Publications

• Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, Devroey P. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril. 2002 Nov;78(5):1025-9. doi: 10.1016/s0015-0282(02)03323-x.
• Papanikolaou EG, Bourgain C, Kolibianakis E, Tournaye H, Devroey P. Steroid receptor expression in late follicular phase endometrium in GnRH antagonist IVF cycles is already altered, indicating initiation of early luteal phase transformation in the absence of secretory changes. Hum Reprod. 2005 Jun;20(6):1541-7. doi: 10.1093/humrep/deh793. Epub 2005 Feb 10.

Study record dates

Study Major Dates

• Study Start: December 1, 2005
• Primary Completion (Actual): December 1, 2007
• Study Completion (Actual): December 1, 2007

Study Registration Dates

• First Submitted: February 16, 2007
• First Submitted That Met QC Criteria: February 16, 2007
• First Posted (Estimate): February 19, 2007

Study Record Updates

• Last Update Posted (Estimate): November 9, 2009
• Last Update Submitted That Met QC Criteria: November 6, 2009
• Last Verified: November 1, 2009

More Information

Terms related to this study

• Keywords: IVF; Endometrium; Steroid receptors; Follicular phase
• Other Study ID Numbers: UHR-4