Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

January 18, 2011 updated by: University Hospital, Clermont-Ferrand

Gilles de la Tourette's syndrome is a childhood onset inherited neuropsychiatric disorder characterised by the presence of both multiple motor tics and one or more vocal tics (noises), with psychiatric and/or behaviour disorders (such as obsessive compulsive behaviour…).

This disease is associated with an dopamine system imbalance which could be responsible of a specific trouble in the recognition in some facial expression. This has been already shown in Gilles de la Tourette patients with obsessive compulsive behaviour.

We hypothesise that patients with Gilles de la Tourette's syndrome present a dysfunction of voluntary and automatic treatment of emotional information.

The main purpose of this study is to show if patients with Gilles de la Tourette's syndrome present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

20 patients with Gilles de la Tourette's syndrome compared to 20 healthy paired volunteers.

Study progress (patients):

Inclusion visit :

Psychiatric evaluation Psychological evaluation

Ophthalmic visit

Protocol :

Facial expression recognition test Lexical decision test

Study progress (healthy volunteers):

Psychiatric evaluation Ophthalmic visit Facial expression recognition test Lexical decision test

Study Type

Observational

Enrollment (Anticipated)

60

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Clermont-Ferrand, France, 63003
        • CHU

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

30 patients with Gilles de la Tourette's Syndrome and 30 healthy paired volunteers (control group)

Description

Inclusion Criteria:

  • Age : >18 years
  • Patient with a Gilles de la Tourette 's syndrome such as defined in the DSMIV
  • Stability of treatment >1 month
  • Mini Mental State > 26
  • Affiliation to social security
  • Agreement of patients

Exclusion Criteria:

  • Patients with cognitive disorders, dementia, mental retardation…
  • Patients with serious neurological pathologies
  • Patients with a vision contrast altered.
  • Patients who do not understand the words associated with an emotion
  • Pregnant women
  • Person who participate to an other study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
2
One group with Gilles de la Tourette's Syndrome One group with healthy paired volunteers
Behavioral: Facial expression recognition of emotion
Facial expression recognition test Lexical decision test

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Facial expression recognition test
Time Frame: % of exact responses
% of exact responses

Secondary Outcome Measures

Outcome Measure
Time Frame
Lexical decision test
Time Frame: The time to respond
The time to respond

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Clermont-Ferrand

Investigators

  • Principal Investigator: Isabelle Jalenques, PUPH, University Hospital, Clermont-Ferrand

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2007

Primary Completion (ACTUAL)

October 1, 2008

Study Completion (ACTUAL)

October 1, 2009

Study Registration Dates

First Submitted

April 21, 2008

First Submitted That Met QC Criteria

April 21, 2008

First Posted (ESTIMATE)

April 22, 2008

Study Record Updates

Last Update Posted (ESTIMATE)

January 19, 2011

Last Update Submitted That Met QC Criteria

January 18, 2011

Last Verified

January 1, 2011

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CHU-0032
  • RBHP 2007 Jalenques

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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