Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools (proto nage)

December 18, 2008 updated by: Laval University

Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

  1. to compare the prevalence of asthma in swimmers and control subjects
  2. to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects
  3. to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Canada
    • Quebec
      • Québec, Quebec, Canada, G1V4G5
        • Recruiting
        • Centre de recherche en pneumologie et en cardiologie de l'hôpital Laval
        • Contact:
        • Contact:
        • Principal Investigator:
          • Louis-Philippe BOULET, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

14 years to 35 years (Child, Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Swimmers from Quebec swimming school and universities Control from université Laval or secondary School

Description

Inclusion Criteria:

  • 14 to 35 years old
  • To swim at least 10h per week
  • For control subjects, non-competitive healthy subjects

Exclusion Criteria:

  • any disease that may interfere with the tests for the controls
  • Triathletes are excluded
  • Smokers
  • Obese or with a BMI more than 29
  • Former athletes (control group)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Control
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
1
Swimmers without AHR
2
Swimmers with asymptomatic AHR
3
Swimmers with symptomatic AHR and use only of beta-2 adrenargic
4
Swimmers with asthma and inhaled corticosteroids
5
Healthy Subjects
6
Healthy subjects with AHR
7
Healthy subjects with symptomatic AHR (asthma) but without treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Asthma and airway hyperreactivity prevalence in swimmers
Time Frame: 3 measurements in the year
3 measurements in the year

Secondary Outcome Measures

Outcome Measure
Time Frame
Airway inflammation and remodeling in swimmers
Time Frame: 3 measurements in the year and a bronchial biopsy
3 measurements in the year and a bronchial biopsy

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Laval University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2007

Primary Completion (Anticipated)

May 1, 2009

Study Completion (Anticipated)

May 1, 2009

Study Registration Dates

First Submitted

May 26, 2008

First Submitted That Met QC Criteria

May 28, 2008

First Posted (Estimate)

May 29, 2008

Study Record Updates

Last Update Posted (Estimate)

December 22, 2008

Last Update Submitted That Met QC Criteria

December 18, 2008

Last Verified

May 1, 2008

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CER20159

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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