Investigation of Efficiency of Breathing With Different Breathing Patterns

Investigation of Efficiency of Breathing With Different Breathing Patterns in Healthy Volunteers and Patients With Respiratory Failure

Our aim in this study is to investigate the efficiency of the breathing with different breathing patterns. Ten volunteers and twenty patients having respiratory problems will be coached on their breathing through specific masks which will provide four different breathing patterns. These patterns will be 1) Breathing in through the nose only and out through the mouth only 2) Breathing in through the mouth only and out through the nose only 3) Breathing in and out through the nose only 4) Breathing in and out through the mouth only The data obtained from volunteers and patients will be compared within and between the groups.

Study Overview

• Status: Completed
• Conditions: Respiratory Insufficiency; Respiratory Physiology; Breathing Patterns
• Intervention / Treatment: Other: Breathing Patterns

• Study Type: Interventional
• Enrollment (Actual): 26
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Massachusetts
    • Boston, Massachusetts, United States, 02114
      • Massachusetts General Hospital, Respiratory Care Laboratory

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• For healthy subjects:

  1. Ten healthy adult (> 18 years of age) volunteers will be recruited from the MGH main campus through intra-hospital e-mail broadcasting. Subjects with the following issues will be excluded from the study.

• For patients with respiratory insufficiency:

  1. Twenty adult (> 18 years of age) patients will be recruited. These patients will be either patients in acute respiratory failure resulting from COPD exacerbation breathing spontaneously only receiving nasal oxygen admitted to the medical floors of the MGH; or patients with diagnosed stable COPD on home oxygen therapy seen by pulmonary physicians in the outpatient clinics or coming to the MGH as study subjects.

Exclusion Criteria:

• For healthy volunteers:

  1. Subjects with facial deformity, heavy beard or moustache which prevents good seal between the mask and the face;
  2. Subjects who have claustrophobia and cannot wear the mask.

• For patients with respiratory insufficiency:

  1. Patients with facial deformity, heavy beard or moustache which prevents a good seal between the mask and the face;
  2. Patients who have claustrophobia and cannot wear the mask.
  3. Patients who are hemodynamically unstable.
  4. Patients requiring continuous noninvasive positive pressure ventilation or endotracheal intubation.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Volunteers; Ten healthy volunteers	Other: Breathing Patterns; All subjects will breathe in four different breathing patterns which are provided by specific masks. Patterns are as the following: Breathing in through the nose only and out through the mouth only; Breathing in through the mouth only and out through the nose only; Breathing in and out through the nose only; Breathing in and out through the mouth only
Other: Patients; Sixteen patients with respiratory insufficiency	Other: Breathing Patterns; All subjects will breathe in four different breathing patterns which are provided by specific masks. Patterns are as the following: Breathing in through the nose only and out through the mouth only; Breathing in through the mouth only and out through the nose only; Breathing in and out through the nose only; Breathing in and out through the mouth only

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Determining the anatomic dead space change at variable tidal volumes with four different breathing patterns (nose-in and nose-out, mouth-in and mouth-out, nose-in and mouth-out, mouth-in and nose-out) in healthy volunteers.	3 months
Comparing the efficiency of CO2 removal at given minute ventilations with the four different breathing patterns in patients with chronic respiratory failure.	6 months

Secondary Outcome Measures

Outcome Measure	Time Frame
Comparing the efficiency of the study mask which forces subjects to breathe in a manner similar to pursed lip breathing and a regular facemask in healthy volunteers and patients with respiratory failure	6 months

Collaborators and Investigators

• Sponsor: Massachusetts General Hospital

Publications and helpful links

General Publications

• Sulemanji DS, Bao F, Jiang Y, Kacmarek RM. A unidirectional breathing pattern improves breathing efficiency in subjects with severe COPD. Respir Care. 2014 Oct;59(10):1487-93. doi: 10.4187/respcare.02899. Epub 2014 Apr 29.

Study record dates

Study Major Dates

• Study Start: November 1, 2007
• Primary Completion (Actual): June 1, 2011
• Study Completion (Actual): June 1, 2011

Study Registration Dates

• First Submitted: October 30, 2008
• First Submitted That Met QC Criteria: October 31, 2008
• First Posted (Estimate): November 2, 2008

Study Record Updates

• Last Update Posted (Estimate): December 2, 2014
• Last Update Submitted That Met QC Criteria: December 1, 2014
• Last Verified: December 1, 2014

More Information

Terms related to this study

• Keywords: breathing patterns,; unidirectional breathing,; mask ventilation,; respiratory physiology
• Additional Relevant MeSH Terms: Pathologic Processes; Respiratory Tract Diseases; Respiration Disorders; Respiratory Aspiration; Respiratory Insufficiency
• Other Study ID Numbers: 2007-P-001371