Investigation of Efficiency of Breathing With Different Breathing Patterns
Investigation of Efficiency of Breathing With Different Breathing Patterns in Healthy Volunteers and Patients With Respiratory Failure
研究概览
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Massachusetts
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Boston、Massachusetts、美国、02114
- Massachusetts General Hospital, Respiratory Care Laboratory
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
For healthy subjects:
1. Ten healthy adult (> 18 years of age) volunteers will be recruited from the MGH main campus through intra-hospital e-mail broadcasting. Subjects with the following issues will be excluded from the study.
For patients with respiratory insufficiency:
- Twenty adult (> 18 years of age) patients will be recruited. These patients will be either patients in acute respiratory failure resulting from COPD exacerbation breathing spontaneously only receiving nasal oxygen admitted to the medical floors of the MGH; or patients with diagnosed stable COPD on home oxygen therapy seen by pulmonary physicians in the outpatient clinics or coming to the MGH as study subjects.
Exclusion Criteria:
For healthy volunteers:
- Subjects with facial deformity, heavy beard or moustache which prevents good seal between the mask and the face;
- Subjects who have claustrophobia and cannot wear the mask.
For patients with respiratory insufficiency:
- Patients with facial deformity, heavy beard or moustache which prevents a good seal between the mask and the face;
- Patients who have claustrophobia and cannot wear the mask.
- Patients who are hemodynamically unstable.
- Patients requiring continuous noninvasive positive pressure ventilation or endotracheal intubation.
学习计划
研究是如何设计的?
设计细节
- 主要用途:支持治疗
- 分配:非随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
---|---|
其他:Volunteers
Ten healthy volunteers
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All subjects will breathe in four different breathing patterns which are provided by specific masks. Patterns are as the following:
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其他:Patients
Sixteen patients with respiratory insufficiency
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All subjects will breathe in four different breathing patterns which are provided by specific masks. Patterns are as the following:
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
---|---|
Determining the anatomic dead space change at variable tidal volumes with four different breathing patterns (nose-in and nose-out, mouth-in and mouth-out, nose-in and mouth-out, mouth-in and nose-out) in healthy volunteers.
大体时间:3 months
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3 months
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Comparing the efficiency of CO2 removal at given minute ventilations with the four different breathing patterns in patients with chronic respiratory failure.
大体时间:6 months
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6 months
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次要结果测量
结果测量 |
大体时间 |
---|---|
Comparing the efficiency of the study mask which forces subjects to breathe in a manner similar to pursed lip breathing and a regular facemask in healthy volunteers and patients with respiratory failure
大体时间:6 months
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6 months
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 2007-P-001371
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