Analysis of Cortical Excitability in Neuropathic Pain

April 1, 2010 updated by: National Taiwan University Hospital

Analysis of Cortical Excitability in Neuropathic Pain: an Electrophysiology Study.

The purpose of this study is to determine whether patients with neuropathic pain has abnormal excitability in somatosensory cortex and abnormal sensory-motor connections.

Study Overview

Status

Unknown

Conditions

Detailed Description

There are several brain areas responsible for neuropathic pain reported in functional image studies, including primary sensory cortex, insula, and anterior cingulate gyrus. However, it is few informations about the functional status of these areas. Besides, the reason of the individual variability about the developement of neuropathic pain remains unknown. It is lack of satisfactory explanation about why some people developed neuropathic pain in certain diseased situation (for example, type 2 diabetes), while others do not.

We hypothesis that patients with neuropathic pain has abnormal cortical excitability and plasticity in certain brain area. Therefore developed neuropathic pain certain diseased condition while others not. Therefore, we will use multimodal electrophysiology tools,such as transcranial magnetic stimulation, peripheral nerve stimulation, and contact heat evoke potential to monitor the cortical excitability and plasticity non-invasively.

Study Type

Observational

Enrollment (Anticipated)

80

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Ch-Chao Chao, M.D.
  • Phone Number: 9801967 886-2-23123456
  • Email: ccchao@ntu.edu.tw

Study Locations

  • Taiwan
      • Taipei, Taiwan, 100
        • Recruiting
        • National Taiwan University Hospital
        • Contact:
        • Contact:
        • Sub-Investigator:
          • Ming-Kai Pan, M.D.
        • Principal Investigator:
          • Sung-Tsang Hsieh, M.D. PhD
        • Sub-Investigator:
          • Chi-Chao Chao, M.D.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Primary care clinic healthy volunteer

Description

Inclusion Criteria:

  • Healthy volunteers
  • patients with pain resulted from dysfunction of peripheral or central nervous system
  • the disorders of peripheral nerves are diagnosed by nerve conduction study, quantitative sensory test, quantification of skin innervation or contact heat evoked potentials
  • lesion of central nervous system should be confirmed by neuroimage.

Exclusion Criteria:

  • previous history of epilepsy, seizure disorders or major head injury
  • previous brain surgery or intracranial metalic implant
  • implanted devices as cardiac pacemaker
  • pregnant subjects
  • patient with severe cardiac or pulmonary disease who potentially cannot tolerate stress

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
1
Healthy volunteers
2
Patient with neuropathic pain
3
patients without neuropathic pain

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Abnormal cortical excitability in motor-sensory cross-talk
Time Frame: non-applicable
non-applicable

Secondary Outcome Measures

Outcome Measure
Time Frame
Genetic variability of neurotrophic factors between groups
Time Frame: non-applicable
non-applicable

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Taiwan University Hospital

Investigators

  • Study Director: Ming-Kai Pan, M.D., National Taiwan University Hospital, Department of Neurology
  • Study Director: Chi-Chao Chao, M.D., National Taiwan University Hospital, Department of Neurology
  • Principal Investigator: Sung-Tsang Hsieh, M.D. PhD, National Taiwan University Hospital, Department of Neurology

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2008

Primary Completion (Anticipated)

October 1, 2011

Study Completion (Anticipated)

October 1, 2011

Study Registration Dates

First Submitted

November 10, 2008

First Submitted That Met QC Criteria

November 10, 2008

First Posted (Estimate)

November 11, 2008

Study Record Updates

Last Update Posted (Estimate)

April 2, 2010

Last Update Submitted That Met QC Criteria

April 1, 2010

Last Verified

March 1, 2010

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 200806061R

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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