Risk Factors of Recovery Room Delirium After Elective Non-cardiovascular Surgery

Risk Factors of Recovery Room Delirium After Elective Non-cardiovascular Surgery in Post-anaesthesia Care Unit

Despite recent advances in postoperative delirium research, the proportion of patients with postoperative delirium is still high ranging between 20-80%. Although postoperative delirium is a frequent complication and is associated with the need for more inpatient hospital care and longer length of hospital stay, little is known about risk factors for recovery room delirium (RRD) occurred in postanaesthesia care unit. The aim of the study was to determine pre- and intraoperative risk factors for the development of RRD among patients undergoing non cardiovascular surgery.

Study Overview

• Status: Completed
• Conditions: Delirium

Detailed Description

Recovery room delirium (RRD) defined as delirium occurred in PACU was diagnosed according to CAM-ICU criteria. Pre-, intra-, and postoperative data of patients undergoing elective non cardiovascular surgery were prospectively collected, univariate and multivariate logistic regression were performed to find the risk factors related to postoperative delirium.

• Study Type: Observational
• Enrollment (Actual): 228

Contacts and Locations

Study Locations

• China
  • Hubei
    • Wuhan, Hubei, China, 430030
      • Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Patients over the age of 18yr, who were admitted to the PACU after elective surgery under general anaesthesia during regular working hours (9:00Am to 5:00Pm)

Description

Inclusion Criteria:

• elective non-cardiovascular surgery
• general anesthesia

Exclusion Criteria:

• under 18yr of age
• under regional anaesthesia
• refused to sign consent form
• history of substance dependence
• underwent neurosurgery
• history of primary neurologic diseases
• stayed less than 10min in PACU
• received general anaesthesia but recovered in locations outside the recovery room

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Delirium; Delirium was determined by CAM-ICU
no Delirium; no Delirium was determined by CAM-ICU

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
The incidence of delirium in post anesthesia care unit (PACU) determined by confusion assessment method (CAM) -ICU criteria	at 1 hour after operation

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
heart rate in PACU	heart rate was recorded every 10 min during PACU stay, maximal and minimal heart rate were collected for analysis	every 10 mins
Pulse Oximeter Oxygen Saturation (SpO2) in PACU		every 10 mins
Hospital-length of stay		up to 6 months
Total health care fees		up to 6 months

Collaborators and Investigators

• Sponsor: Huazhong University of Science and Technology

Study record dates

Study Major Dates

• Study Start: June 1, 2010
• Primary Completion (Actual): June 30, 2010
• Study Completion (Actual): June 30, 2010

Study Registration Dates

• First Submitted: October 7, 2009
• First Submitted That Met QC Criteria: October 7, 2009
• First Posted (Estimate): October 8, 2009

Study Record Updates

• Last Update Posted (Actual): July 21, 2020
• Last Update Submitted That Met QC Criteria: July 20, 2020
• Last Verified: July 1, 2020

More Information

Terms related to this study

• Keywords: Postoperative; Delirium; Non-cardiovascular surgery; Post-anaesthesia care unit
• Additional Relevant MeSH Terms: Mental Disorders; Nervous System Diseases; Neurologic Manifestations; Confusion; Neurobehavioral Manifestations; Neurocognitive Disorders; Delirium
• Other Study ID Numbers: TJHMZK02001