- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01013610
An Escalating Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of LNK 754 in Elderly Volunteers and in Subjects With Mild Alzheimer's Disease
A Double-Blind, Randomized, Placebo-Controlled, Multiple, Escalating Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of LNK 754 in Elderly Volunteers and in Subjects With Mild Alzheimer's Disease
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Phase
- Phase 1
Contacts and Locations
Study Locations
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Arizona
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Phoenix, Arizona, United States, 85013
- Dedicated Phase I
-
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California
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Long Beach, California, United States, 90806
- Collaborative NeuroScience Network
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Florida
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Miami, Florida, United States, 33169
- Elite Research Insitute
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Orlando, Florida, United States, 32806
- Compass Research, LLC
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Georgia
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Atlanta, Georgia, United States, 30308
- Atlanta Center for Medical Research
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Missouri
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St. Louis, Missouri, United States, 63118
- St. Louis Clinical Trials, LC
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Texas
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Houston, Texas, United States, 77074
- Clinical Trial Network
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
Part A and Part B:
- Males or females aged 60 years or older. Females must be surgically sterilized or postmenopausal for at least two years. Males must be actively practicing double-barrier contraception (condom plus spermicide), unless they have had a vasectomy, or their partner(s) meet the above criteria for females.
- Voluntarily consent to participate in this study and provide written informed consent prior to start of any study-specific procedures.
Be prepared to adhere to the protocol requirements and be willing and able to remain in the study unit for the entire duration of the confinement period. They must also be willing to return for the End-of-Study Visit one week after the last dosing.
Part A only:
Subjects must be generally healthy, but may be enrolled with a stable, chronic illness, if it is well controlled and does not interfere with the primary objective of the study. Subjects may be included with clinical deviations from normal limits in medical history, physical examination, vital sign measurements, ECG, or laboratory test results that are associated with stable, well controlled chronic illness. Subjects with concomitant diseases or using concomitant medication will be allowed to participate provided a stable condition and stable treatment for 1 month (30 days) prior to administration of the first dose of study medication. Inclusion of each subject will be reviewed with the Link Medical Monitor prior to enrollment in the trial.
Part B only:
- Subjects with Mild Alzheimer's Disease, as defined by DSM-IV.
- Subjects with a score of ≥ 18-26 on the Mini-Mental State Examination (MMSE).
- Subjects with a Clinical Dementia Rating (CDR) total score of 0.5 or 1.0 (possible or mild dementia).
- Subjects with a Rosen-Modified Hachinski Ischemic score of ≤ 4.
Exclusion Criteria:
Part A and Part B:
- Any significant unstable or uncontrolled cardiovascular, hepatic, renal, respiratory, gastrointestinal, endocrine, immunologic, dermatologic, hematologic, neurologic, or psychiatric disease, as determined by medical history, physical examination or laboratory tests.
- Subjects who have positive serologic findings for human immunodeficiency virus (HIV) antibodies, hepatitis B surface antigen (HBsAg), and/or hepatitis C virus (HCV) antibodies.
- Subjects who have received any experimental drugs or devices within 30 days prior to dosing or who wish to receive any experimental drug within 30 days after completing the study.
- Subjects unable to understand the protocol requirements, instructions and study related restrictions, the nature, scope and possible consequences of the clinical study.
Study Plan
How is the study designed?
Design Details
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Placebo
|
Escalating dose
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Active Comparator: Multiple Dose
|
Escalating dose
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Safety assessments to include pharmacokinetics, and adverse events
Time Frame: 24 hours
|
24 hours
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Abel Murillo, MD, Elite Research Institute
- Principal Investigator: Craig T. Curtis, MD, Compass Research
- Principal Investigator: Kyle Patrick, D.O., Dedicated Phase I
- Principal Investigator: Maxwell Axler, MD, Clinical Trial Network
- Principal Investigator: Ricky S. Mofsen, D.O., St. Louis Clinical Trials, LC
- Principal Investigator: Armen Goenjian, MD, Collaborative NeuroScience Network
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- LNK754-0902-1AB
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Mild Alzheimer's Disease
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Centers for Medicare and Medicaid Services/ Coverage...RecruitingMild Alzheimer's Disease | Mild Cognitive Impairment (MCI) Due to Alzheimer's DiseaseUnited States
-
Neuroscience Trials AustraliaThe Florey Institute of Neuroscience and Mental HealthActive, not recruitingMild Cognitive Impairment | Prodromal Alzheimer's Disease | Mild Alzheimer's DiseaseAustralia
-
University of KonstanzUniversity of UlmCompletedMild Cognitive Impairment (MCI) | Mild Alzheimer's DiseaseGermany
-
Novartis PharmaceuticalsTerminatedAmnestic Mild Cognitive Impairment | Mild Alzheimer's DiseaseCanada, United Kingdom, South Africa
-
PRInnovation GmbHJulius Clinical; Federal Agency for Disruptive Innovation - SPRIN-D; PriavoidRecruitingMild Cognitive Impairment Due to Alzheimer's Disease | Alzheimer's Disease, Early OnsetSpain, Italy, Germany, Netherlands, Czechia, France, Poland
-
BiogenRecruitingMild Cognitive Impairment Due to Alzheimer's Disease | Alzheimer's Disease DementiaBelgium, United States, Australia, Italy, Spain, Denmark, United Kingdom, Czechia, France, Poland, Germany, Canada, Japan, Finland, Switzerland, Netherlands, Sweden
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University of California, Los AngelesNational Institute on Aging (NIA)RecruitingMild Cognitive Impairment | Deep Brain Stimulation | Amnestic Mild Cognitive Disorder | Mild Alzheimer's DiseaseUnited States
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University of Rhode IslandBoehringer Ingelheim; Alzheimer's Drug Discovery FoundationUnknownMild Cognitive Impairment | Mild Alzheimer's Disease
-
Louisiana State University Health Sciences Center...CompletedMild Cognitive Impairment | Mild Alzheimer's DiseaseUnited States
-
High Point Pharmaceuticals, LLC.TerminatedMild Cognitive Impairment | Mild Alzheimer's DiseaseUnited States
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