Documentation of Humira in Psoriasis Patients in Routine Clinical Practice (LOTOS)

June 11, 2020 updated by: AbbVie (prior sponsor, Abbott)

Long Term Documentation of the Safety and Efficacy as Well as the Effects on Work Productivity in Patients With Moderate to Severe Plaque Psoriasis Treated With HUMIRA (Adalimumab) in Routine Clinical Practice (LOTOS)

Safety and Effectiveness of adalimumab (Humira) in Psoriasis Patients in Routine Clinical Practice.

Study Overview

Status

Completed

Detailed Description

Postmarketing Observational Study to Evaluate the Work Productivity, Safety and Efficacy of Humira for the Treatment of Moderate to Severe Plaque Psoriasis in Daily Clinical Practice. The primary objectives of the PMOS are to explore changes in health related care utilization data by the evaluation of:

  • the number of missed working days
  • the number of visits to doctor's office
  • the number and duration of hospitalizations
  • work ability to assess efficacy for different subgroups by
  • the number of patients achieving a PASI 75 response to evaluate safety by
  • the documentation and analysis of adverse events for all patients and subgroups with concomitant diseases Secondary objectives include the exploration of changes in quality of life measurements, of the influence of age, gender and duration of disease

Study Type

Observational

Enrollment (Actual)

5442

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

      • AUE, Germany, 08280
        • Hums, Aue, DE /ID# 60601
      • AUE, Germany, 8280
        • Gerloff-Steiner, Aue, DE /ID# 53694
      • Aachen, Germany, 52064
        • Hoeller-Obrigkeit, Aachen, DE /ID# 60599
      • Ahaus, Germany, 48683
        • Petri, Ahaus, DE /ID# 53712
      • Ahrensburg, Germany, 22926
        • Gewiss, Ahrensburg, DE /ID# 33431
      • Alsfeld, Germany, 36304
        • Praxis Dr. Schuessler /ID# 149404
      • Altenkirchen, Germany, 57610
        • Oster-Schmidt, Altenkirchen, D /ID# 126022
      • Amberg, Germany, 92224
        • Weiss, Amberg, DE /ID# 60613
      • Ampfing, Germany, 84539
        • Dietz, Ampfing, DE /ID# 50790
      • Andernach, Germany, 56626
        • Bell, Andernach, DE /ID# 99815
      • Angermuende, Germany, 16278
        • Schulz, Angermuende, DE /ID# 53719
      • Annaberg-buchholz, Germany, 9456
        • Rebbien, Annaberg-Buchholz, DE /ID# 35052
      • Artern, Germany, 06556
        • Thieme, Artern, DE /ID# 35518
      • Aschaffenburg, Germany, 63739
        • Dr. Szlava Fuezesi, Achaffenbu /ID# 118537
      • Aschersleben, Germany, 06449
        • Theuring, Aschersleben, DE /ID# 35058
      • Augsburg, Germany, 86167
        • Schneider & Sedlmayr, Augsburg /ID# 33351
      • Aurich, Germany, 26603
        • Lechner/Stuebich, Aurich, DE /ID# 33355
      • Aurich, Germany, 26603
        • Lechner/Stuebich, Aurich, DE /ID# 67967
      • BAD Muender, Germany, 31848
        • Schulz, Bad Muender, DE /ID# 48469
      • BAD Woerishofen, Germany, 86825
        • Moerstedt, Bad Woerishofen, DE /ID# 99844
      • Bad Berka, Germany, 99438
        • Brautzsch, Bad Berka, DE /ID# 33365
      • Bad Doberan, Germany, 19209
        • Broschewitz/Hammer Bad Doberan /ID# 60596
      • Bad Doberan, Germany, 19209
        • Broschewitz/Hammer Bad Doberan /ID# 67948
      • Bad Kreuznach, Germany, 55543
        • Mauer, Bad Kreuznach, DE /ID# 126019
      • Bad Reichenhall, Germany, 83435
        • SALUS-Klinik /ID# 33405
      • Bad Rothenfelde, Germany, 49214
        • Praxis Dr. Bock /ID# 166127
      • Bad Schlema, Germany, 8301
        • Houda, Bad Schlema, DE /ID# 35584
      • Bamberg, Germany, 96049
        • Sozialstiftung Bamberg /ID# 33430
      • Bargteheide, Germany, 22941
        • Stephan-Dahm, Bargteheide, DE /ID# 50861
      • Baunatal, Germany, 34225
        • Dr. Roxana Homolka, Baunatal, /ID# 118539
      • Bautzen, Germany, 02625
        • Mirtschink, Bautzen, DE /ID# 50851
      • Bayreuth, Germany, 95444
        • Graessel, Bayreuth, DE /ID# 35587
      • Bayreuth, Germany, 95444
        • Kinateder, Bayreuth, DE /ID# 33439
      • Bendorf, Germany, 56170
        • Blaese & Walther, Bendorf, DE /ID# 50787
      • Benndorf, Germany, 56170
        • Pflieger-Bruss, Benndorf, DE /ID# 53713
      • Bergen, Germany, 18528
        • Timmel/Timm/Vorwerk, Bergen /ID# 33451
      • Bergisch Gladbach, Germany, 51465
        • Wirtler, Bergisch Gladbach, DE /ID# 33452
      • Berlin, Germany, 10117
        • Charité Universitätsmedizin Campus Mitte /ID# 33457
      • Berlin, Germany, 10117
        • Hasert & Hasert, Berlin, DE /ID# 35531
      • Berlin, Germany, 10117
        • Kindler, Berlin, Germany /ID# 60604
      • Berlin, Germany, 10117
        • Klusmann, Berlin, DE /ID# 90974
      • Berlin, Germany, 10247
        • Spickermann, Berlin, DE /ID# 33675
      • Berlin, Germany, 10623
        • Praxis Dermatologie am Savigny /ID# 145783
      • Berlin, Germany, 10627
        • Herzler & Reupke, Berlin, DE /ID# 33705
      • Berlin, Germany, 10783
        • Boodstein, Berlin, Germany /ID# 48417
      • Berlin, Germany, 10783
        • Rothhaar, Berlin, DE /ID# 33644
      • Berlin, Germany, 10827
        • Simon, Berlin, DE /ID# 33678
      • Berlin, Germany, 10827
        • Steinhoff-Georgieva, Berlin,DE /ID# 60612
      • Berlin, Germany, 10967
        • Struss, Berlin, DE /ID# 33680
      • Berlin, Germany, 12157
        • Miller/Nerenheim, Berlin, DE /ID# 99842
      • Berlin, Germany, 12159
        • Praxis Dr. med. Meljanac /ID# 151477
      • Berlin, Germany, 12159
        • Praxis Dr. med. Meljanac /ID# 35594
      • Berlin, Germany, 12163
        • Jacob, Berlin, DE /ID# 48438
      • Berlin, Germany, 12351
        • Vivantes Klinikum Neukolln /ID# 34270
      • Berlin, Germany, 12353
        • Weihe/Stavermann, Berlin, DE /ID# 35547
      • Berlin, Germany, 12437
        • Gellrich, Berlin, DE /ID# 33691
      • Berlin, Germany, 12489
        • Schirmer, Berlin, DE /ID# 35534
      • Berlin, Germany, 12587
        • Skarabis/Skarabis, Berlin, DE /ID# 34241
      • Berlin, Germany, 12689
        • Kv Be /Id# 34253
      • Berlin, Germany, 13051
        • Praxis Dres. Eicholtz/Boerner /ID# 167676
      • Berlin, Germany, 13055
        • Wildfeuer, Berlin, DE /ID# 33694
      • Berlin, Germany, 13086
        • Kors, Berlin, DE /ID# 33649
      • Berlin, Germany, 13187
        • Zahn, Berlin, DE /ID# 35592
      • Berlin, Germany, 13439
        • Praxis Dr. Uhl /ID# 171308
      • Berlin, Germany, 13507
        • Dues/Manasterski, Berlin, DE /ID# 35538
      • Berlin, Germany, 13507
        • Miehe & Partner, Berlin, DE /ID# 166125
      • Berlin, Germany, 13507
        • Miehe & Partner, Berlin, DE /ID# 35544
      • Berlin, Germany, 13593
        • Baumann, Berlin, DE /ID# 60584
      • Berlin, Germany, 14052
        • Groene, Berlin, DE /ID# 60594
      • Bernau, Germany, 16321
        • Neumann, Bernau, DE /ID# 34271
      • Bernau Bei Berlin, Germany, 16321
        • Praxis Dr. Duhn /ID# 167672
      • Bielefeld, Germany, 33602
        • Biel, Bielefeld, DE /ID# 60586
      • Bielefeld, Germany, 33607
        • MVZ Otto-Brenner-Straße /ID# 167677
      • Bielefeld, Germany, 33647
        • Staedt Kliniken Bielefeld /ID# 35558
      • Birkenwerder, Germany, 16547
        • Dabour & Dabour, Birkenwerder /ID# 34280
      • Bitterfeld, Germany, 6749
        • Wege & Kuehnast, Bitterfeld /ID# 34282
      • Blaubeuren, Germany, 89143
        • Praxis fuer Innere Medizin/Rhe /ID# 35564
      • Bocholt, Germany, 46397
        • Ruppert, Bocholt, DE /ID# 108918
      • Bochum, Germany, 44791
        • Klinikum Ruhr Univ Bochum /ID# 35091
      • Bochum, Germany, 44793
        • GP Dr. Niesman & Dr. Othlingha /ID# 169694
      • Bochum, Germany, 44803
        • Ardabili/Niesmann, Bochum, DE /ID# 50784
      • Bonn, Germany, 53113
        • Universitaetsklinikum Bonn /ID# 34299
      • Borken, Germany, 46325
        • Praxis Dr. Schift /ID# 141549
      • Borna, Germany, 04552
        • Barth, Borna, DE /ID# 35650
      • Borna, Germany, 04552
        • Barth, Borna, DE /ID# 67946
      • Bottrop, Germany, 46236
        • Alte Apotheke /ID# 48530
      • Bottrop, Germany, 46236
        • Flont-Schmeling, Bottrop, DE /ID# 48423
      • Bottrop, Germany, 46236
        • Karpinski, Bottrop, DE /ID# 34303
      • Brake, Germany, 26919
        • Tolzin, Brake, DE /ID# 50866
      • Brandenburg, Germany, 14776
        • Klee/Wolff, Brandenburg, DE /ID# 67960
      • Brandenburg An Der Havel, Germany, 14770
        • Praxis S. Osadtschy /ID# 161167
      • Braunschweig, Germany, 38100
        • Atugoda, Braunschweig, DE /ID# 48509
      • Braunschweig, Germany, 38100
        • Gaedt, Braunschweig, DE /ID# 67954
      • Braunschweig, Germany, 38114
        • Koehn & Ramaker-Brunke, DE /ID# 34309
      • Bremen, Germany, 28205
        • Klinikverbund Bremen /ID# 171306
      • Bremen, Germany, 28209
        • Elsner, Bremen, DE /ID# 48422
      • Bremen, Germany, 28239
        • Derma am Diako /ID# 166131
      • Bremen, Germany, 28239
        • Hermann/Teichelmann, Bremen,DE /ID# 35605
      • Bremen, Germany, 28259
        • Altvater/Tauschke, Bremen, DE /ID# 34311
      • Bremen, Germany, 28779
        • Schwichtenberg, Bremen, DE /ID# 34312
      • Bremerhaven, Germany, 27570
        • Friedmann, Bremerhaven, DE /ID# 67952
      • Bremerhaven, Germany, 27572
        • Heitmann, Bremerhaven, DE /ID# 148410
      • Buchholz, Germany, 21244
        • Bessle, Buchholz, DE /ID# 60585
      • Buchholz I.D. Nordheide, Germany, 21244
        • Streit, Buchholz, DE /ID# 53723
      • Burg, Germany, 39288
        • Arensmeier-Gottschalkson, Burg /ID# 48508
      • Burgstadt, Germany, 09217
        • Praxis K. Neubert /ID# 149400
      • Burscheid, Germany, 51399
        • Wagenpfeil, Burscheid, DE /ID# 99856
      • Buxtehude, Germany, 21614
        • Elbe Klinikum Buxtehude /ID# 34694
      • Chemnitz, Germany, 09116
        • Praxis B. Jaeckel /ID# 145768
      • Chemnitz, Germany, 09119
        • Jaeckel & Partner, Chemnitz, D /ID# 34703
      • Chemnitz, Germany, 09123
        • Kuehn/Stengel, Chemnitz, DE /ID# 90978
      • Chemnitz, Germany, 09130
        • Praxis P. Hausler-Mehlhorn /ID# 149285
      • Chemnitz, Germany, 9116
        • Schneider, Chemnitz, DE /ID# 35613
      • Coburg, Germany, 96450
        • Hoffmann, Coburg, DE /ID# 34704
      • Coesfeld, Germany, 48653
        • Pappai, Coesfeld, DE /ID# 108917
      • Cologne, Germany, 50679
        • Karger/Rezazadegan, Cologne DE /ID# 60608
      • Cologne, Germany, 50733
        • Menge & Franckson, Cologne, DE /ID# 53708
      • Cologne, Germany, 50935
        • Haitas-Haase, Cologne, DE /ID# 53696
      • Cologne, Germany, 50969
        • Haase & Partner, Cologne, DE /ID# 53724
      • Cologne, Germany, 51103
        • Praxis Dres. Neuhaus/Sacha /ID# 149403
      • Cologne, Germany, 51109
        • Matias-Bako/Krickeberg,Cologne /ID# 90975
      • Cologne, Germany, 51143
        • Eichhorn, Cologne, DE /ID# 99818
      • Coswig, Germany, 01640
        • Krebs, Coswig, DE /ID# 48519
      • Cottbus, Germany, 03046
        • Praxis S.-K. Strenzke /ID# 145781
      • Cottbus, Germany, 3046
        • Dr. Bernd Jantsch, Cottbus, DE /ID# 35618
      • Cottbus, Germany, 3046
        • Loessner, Cottbus, DE /ID# 34712
      • Cottbus, Germany, 3048
        • Dr. Susanne Jantsch,Cottbus,DE /ID# 35619
      • Darmstadt, Germany, 64297
        • Klinikum Darmstadt GmbH /ID# 34720
      • Delmenhorst, Germany, 27749
        • Buelow, Delmenhorst, DE /ID# 35626
      • Delmenhorst, Germany, 27753
        • Thelen, Delmenhorst, DE /ID# 35628
      • Dessau-rosslau, Germany, 6842
        • Heidlas, Dessau-Rosslau, DE /ID# 34730
      • Detmold, Germany, 32756
        • Klinikum Lippe Detmold GmbH /ID# 34731
      • Dieburg, Germany, 64807
        • Friedrich, Dieburg, DE /ID# 53693
      • Diez, Germany, 65582
        • Gerharz, Diez, DE /ID# 48432
      • Dinkelsbuehl, Germany, 91550
        • Winter, Dinkelsbuehl, DE /ID# 34734
      • Dormagen, Germany, 41539
        • Ghassem-Zadeh/Farashahi /ID# 138188
      • Dorsten, Germany, 46282
        • Thomas, Dorsten, DE /ID# 34736
      • Dortmund, Germany, 44137
        • Brinkmeier & Partner, Dortmund /ID# 138259
      • Dortmund, Germany, 44137
        • Brinkmeier & Partner, Dortmund /ID# 99847
      • Dortmund, Germany, 44137
        • Hautklinik Dortmund /ID# 72019
      • Dortmund, Germany, 44287
        • Hirschmueller, Dortmund, DE /ID# 34737
      • Dortmund, Germany, 44309
        • Bebnowski, Dortmund, DE /ID# 53684
      • Dortmund, Germany, 44369
        • Dick/Hubert/Mirkin, Dortmund /ID# 99843
      • Dortmund, Germany, 44388
        • Frolova, Dortmund, DE /ID# 51022
      • Dresden, Germany, 01067
        • Frach/Hohaus, Dresden, DE /ID# 35166
      • Dresden, Germany, 01067
        • Frach/Hohaus, Dresden, DE /ID# 60600
      • Dresden, Germany, 01097
        • Gerlach, Dresden, DE /ID# 48433
      • Dresden, Germany, 01097
        • Praxis Dres. Pollack Schramm /ID# 149286
      • Dresden, Germany, 01109
        • Kuehn, Dresden, DE /ID# 34752
      • Dresden, Germany, 01159
        • Schamfuss, Dresden, DE /ID# 48468
      • Dresden, Germany, 01219
        • Richter-Huhn, Dresden, DE /ID# 35164
      • Dresden, Germany, 01279
        • Hass, Dresden, Germany /ID# 60597
      • Dresden, Germany, 01307
        • Meier, Dresden, DE /ID# 48452
      • Dresden, Germany, 01307
        • Universitaetklinikum Dresden /ID# 34764
      • Dresden, Germany, 01307
        • University Clinic Carl Gustav /ID# 99820
      • Dresden, Germany, 01309
        • Praxis Dr. Mayer /ID# 148243
      • Dresden, Germany, 1217
        • Scheibner, Dresden, DE /ID# 35162
      • Dresden, Germany, 1277
        • Oppers, Dresden, DE /ID# 126021
      • Duelmen, Germany, 48249
        • Bockhorst & Dominicus, Duelmen /ID# 34765
      • Dueren, Germany, 52349
        • Korge, Dueren, DE /ID# 35174
      • Duesseldorf, Germany, 40217
        • Evangelisches Krankenhaus Dues /ID# 48419
      • Duisburg, Germany, 47166
        • Siebert, Duisburg, DE /ID# 34775
      • Duisburg, Germany, 47167
        • St. Barbara-Hospital /ID# 81302
      • Duisburg, Germany, 47179
        • Praxis. Y. Teoman /ID# 142005
      • Duisburg, Germany, 47239
        • Elsner, Duisburg, DE /ID# 99819
      • Duisburg, Germany, 47249
        • Saget & Riesopp, Duisburg, DE /ID# 35175
      • Duisburg, Germany, 47259
        • Praxis Dr. Lobert /ID# 145774
      • Eberswalde, Germany, 16225
        • Berendt, Eberswalde, DE /ID# 35178
      • Eilenburg, Germany, 4838
        • Badura, Eilenburg, DE /ID# 35179
      • Einbeck, Germany, 37574
        • Praxis Dr. Kues /ID# 145771
      • Eisenach, Germany, 99817
        • Dove, Eisenach, DE /ID# 48420
      • Eisenach, Germany, 99817
        • Reinhardt, Eisenach, DE /ID# 48465
      • Eisenhuettenstadt, Germany, 15890
        • Rast, Eisenhuettenstadt, DE /ID# 34789
      • Eisenhuettenstadt, Germany, 15890
        • Richter/Cyw, Eisenhuettenstadt /ID# 34790
      • Eisleben, Germany, 06295
        • Noack, Lutherstadt Eisleben,DE /ID# 48521
      • Ellwangen, Germany, 73479
        • Schmid, Ellwangen, DE /ID# 34792
      • Elmshorn, Germany, 25337
        • Praxis Dr. Fitz /ID# 145767
      • Eltville, Germany, 65343
        • Hartl, Eltville, DE /ID# 34796
      • Emden, Germany, 26721
        • Med X Aerzteteam GmbH /ID# 90977
      • Emden, Germany, 26721
        • Meinert, Emden, DE /ID# 34797
      • Emsdetten, Germany, 48282
        • Maurer & Krebs-Posingies /ID# 34800
      • Endingen, Germany, 79346
        • Schurhammer-Fuhrmann, Endingen /ID# 67966
      • Erfurt, Germany, 99084
        • Koenig, Erfurg, DE /ID# 99838
      • Erfurt, Germany, 99091
        • Nennstiel, Erfurt, DE /ID# 34804
      • Eschweiler, Germany, 52249
        • Lichtenstein, Eschweiler, DE /ID# 50842
      • Essen, Germany, 45147
        • Praxis Dres. Exner/Kanja /ID# 145769
      • Essen, Germany, 45147
        • Universitaetsklinikum Essen /ID# 34827
      • Essen, Germany, 45147
        • Universitaetsklinikum Essen /ID# 53718
      • Essen, Germany, 45327
        • Klundt, Essen, DE /ID# 138195
      • Essen, Germany, 45329
        • Praxis Dres. Beyer /ID# 141989
      • Essen, Germany, 45329
        • Praxis Dres. Beyer /ID# 90957
      • Essen, Germany, 45355
        • Praxis Dr. Porwollik /ID# 148244
      • Esslingen Am Neckar, Germany, 73728
        • Praxis Dres. Renner/Sohl /ID# 149289
      • Euskirchen, Germany, 53879
        • Huerkamp, Euskirchen, DE /ID# 48517
      • Euskirchen, Germany, 53879
        • Swirski, Euskirchen, DE /ID# 81314
      • Falkensee, Germany, 14612
        • Praxis Dres. Freitag/Knoell /ID# 167675
      • Fitzroy, Germany, 3065
        • Jovic-Paris, Bad Neuenahr /ID# 48439
      • Flensburg, Germany, 24939
        • Godt, Flensburg, DE /ID# 67957
      • Floeha, Germany, 09557
        • Praxis T. Zimmermann /ID# 145784
      • Frankenberg/sa., Germany, 09669
        • Eichinger, Frankenberg, DE /ID# 138260
      • Frankenthal, Germany, 67227
        • Schoengen/Schwarzenbach, Frank /ID# 60610
      • Frankenthal, Germany, 67227
        • Schoengen/Schwarzenbach, Frank /ID# 60611
      • Frankfurt, Germany, 60596
        • Kaufmann, Frankfurt, DE /ID# 35098
      • Frechen, Germany, 50226
        • Hundgeburth, Frechen, DE /ID# 138192
      • Freiberg, Germany, 09599
        • Kaemmerer, Freiberg, DE /ID# 138194
      • Freiburg, Germany, 79098
        • Trefzer, Freiburg im Breisgau, /ID# 126028
      • Freising, Germany, 85354
        • Kurzen, Freising, DE /ID# 67964
      • Fuerstenwalde, Germany, 15517
        • Schmidt, Fuerstenwalde, DE /ID# 34868
      • Fuerth, Germany, 90762
        • Gall, Fuerth, DE /ID# 48431
      • Gaggenau, Germany, 76571
        • Teichler, Gaggenau, DE /ID# 99855
      • Garbsen, Germany, 30823
        • Wolf, Garbsen, DE /ID# 99859
      • Geilenkirchen, Germany, 52511
        • Praxis Dr. Billmann-Krutmann /ID# 149399
      • Gelsenkirchen, Germany, 45886
        • Praxis Dres. Kobus / Wetz /ID# 169692
      • Gelsenkirchen, Germany, 45894
        • Praxis K. R. Koerber & Partner /ID# 151715
      • Gelsenkirchen, Germany, 45894
        • Wetz, Gelsenkirchen, DE /ID# 99858
      • Gelsenkirchen, Germany, 45897
        • Rotterdam, Gelsenkirchen, DE /ID# 50856
      • Gelsenkirchen, Germany, 45899
        • Praxis J. Teichmann & Partner /ID# 145775
      • Gera, Germany, 07545
        • Lange, Dietrich & Beyer, Gera /ID# 48449
      • Gera, Germany, 07545
        • Lange, Dietrich & Beyer, Gera /ID# 81274
      • Gera, Germany, 07545
        • Paul/Meyer, Gera, DE /ID# 54379
      • Gera, Germany, 07548
        • SRH Wald-Klinikum Gera GmbH /ID# 60602
      • Gera, Germany, 07549
        • Schnee, Gera, DE /ID# 81313
      • Gera, Germany, 7546
        • Estel, Gera, DE /ID# 35226
      • Gernsbach, Germany, 76593
        • Loth, Gernsbach, DE /ID# 50844
      • Giessen, Germany, 35390
        • Gross/Braeu, Giessen, DE /ID# 34884
      • Gilching, Germany, 82205
        • Kloevekorn & Tepe, Gilching /ID# 118541
      • Gilching, Germany, 82205
        • Kloevekorn & Tepe, Gilching /ID# 48504
      • Gilching, Germany, 82205
        • Kloevekorn & Tepe, Gilching /ID# 48506
      • Gladbeck, Germany, 45964
        • Brinkmann & Partner, Gladbeck, /ID# 34889
      • Gladbeck, Germany, 45964
        • Brinkmann & Partner, Gladbeck, /ID# 53688
      • Glauchau, Germany, 8371
        • Jahn, Glauchau, DE /ID# 35230
      • Goerlitz, Germany, 02826
        • Hille, Goerlitz, DE /ID# 60598
      • Goettingen, Germany, 37073
        • Cleffmann/Ranke, Goettingen DE /ID# 53689
      • Goettingen, Germany, 37075
        • Univ Medical Center Goettingen /ID# 35103
      • Graefenhainichen, Germany, 06773
        • Kuckert, Graefenhainichen, DE /ID# 48520
      • Grafenau, Germany, 94481
        • Kisslinger/Kisslinger, Grafena /ID# 34897
      • Greifswald, Germany, 17489
        • Herrmann, Greifswald, DE /ID# 72016
      • Grevesmuehlen, Germany, 23936
        • Manke, Grevesmuehlen, DE /ID# 34907
      • Gronau, Germany, 48599
        • Wigbels, Gronau, DE /ID# 48505
      • Grossenhain, Germany, 01558
        • Grossmann, Grossenhain, DE /ID# 126016
      • Guestrow, Germany, 18273
        • Westphal, Guestrow, DE /ID# 35500
      • Hagen, Germany, 58095
        • Busse-Misic, Hagen, DE /ID# 34914
      • Hagen, Germany, 58095
        • Timtschenko, Hagen, DE /ID# 138203
      • Haiger, Germany, 35708
        • Stehl, Haiger, DE /ID# 126027
      • Halle, Germany, 01632
        • Gstoettner, Halle, DE /ID# 48513
      • Halle, Germany, 06108
        • Hamm, Halle, DE /ID# 72015
      • Halle, Germany, 06108
        • Lutze, Halle, DE /ID# 34919
      • Halle, Germany, 06108
        • Reiss, Halle, DE /ID# 35507
      • Halle, Germany, 06108
        • Zarzour, Halle, DE /ID# 35505
      • Halle, Germany, 06114
        • Hetschko, Halle, DE /ID# 48437
      • Halle, Germany, 6120
        • Universitatsklinikum Halle /ID# 34941
      • Hamburg, Germany, 20148
        • Gagu-Koll, Hamburg, DE /ID# 48424
      • Hamburg, Germany, 20246
        • Univ Klinik Eppendorf Hamburg /ID# 35115
      • Hamburg, Germany, 20246
        • Univ Klinik Eppendorf Hamburg /ID# 48453
      • Hamburg, Germany, 20354
        • Dermatologikum Hamburg /ID# 35107
      • Hamburg, Germany, 20354
        • Wagner, Hamburg, DE /ID# 99857
      • Hamburg, Germany, 21073
        • Mengert/Nienstedt, Hamburg, DE /ID# 34995
      • Hamburg, Germany, 21109
        • Luetten, Hamburg, DE /ID# 50847
      • Hamburg, Germany, 22041
        • Kahle/Ohnemus, Hamburg, DE /ID# 148412
      • Hamburg, Germany, 22049
        • Praxis Dres. Harms/Hartmann /ID# 148249
      • Hamburg, Germany, 22111
        • Buerger, Hamburg, DE /ID# 34966
      • Hamburg, Germany, 22143
        • Montag, Hamburg, DE /ID# 35438
      • Hamburg, Germany, 22305
        • Buck, Hamburg, DE /ID# 34964
      • Hamburg, Germany, 22391
        • Dermatologisches Ambulatorium /ID# 35435
      • Hamburg, Germany, 22391
        • Dermatologisches Ambulatorium /ID# 35436
      • Hamburg, Germany, 22457
        • Kunze, Hamburg, DE /ID# 34949
      • Hamburg, Germany, 22457
        • Kuwert/Wendt/Schulz, Hamburg, /ID# 34991
      • Hamburg, Germany, 22459
        • Hautarztpraxis am Tibarg /ID# 35004
      • Hamburg, Germany, 22523
        • Schmolke, Hamburg, DE /ID# 67965
      • Hamburg, Germany, 22587
        • Wrage-Brors, Hamburg, DE /ID# 126030
      • Hamm, Germany, 59065
        • Szabo, Hamm, DE /ID# 35015
      • Hamm, Germany, 59065
        • Weitzel, Hamm, DE /ID# 90982
      • Hanau, Germany, 63450
        • Klinikum Hanau gGmbH /ID# 35020
      • Hannover, Germany, 30159
        • Praxis U. Stein /ID# 171307
      • Hannover, Germany, 30159
        • Theuerkauf, Hanover, DE /ID# 35454
      • Hannover, Germany, 30167
        • Stein, Hanover, DE /ID# 35029
      • Hannover, Germany, 30625
        • Horstmann, Hanover, DE /ID# 35026
      • Heidelberg, Germany, 69115
        • Durani & Durani, Heidelberg,DE /ID# 48421
      • Heidenau, Germany, 01809
        • Alheit, Heidenau, DE /ID# 50782
      • Heilbad Heiligenstadt, Germany, 37308
        • Pawlak, Heilbad Heiligenstadt, /ID# 138191
      • Heilbad Heiligenstadt, Germany, 37308
        • Pawlak, Heilbad Heiligenstadt, /ID# 35466
      • Heilbronn, Germany, 74072
        • Arnold/Kaschubowski/Salzer/Wur /ID# 67971
      • Heilbronn, Germany, 74072
        • Arnold/Kaschubowski/Salzer/Wur /ID# 99837
      • Heiligenhaus, Germany, 42579
        • Schulte/Mainusch, Heiligenhaus /ID# 138202
      • Hennigsdorf, Germany, 16761
        • Postrach, Hennigsdorf, DE /ID# 35468
      • Herrnhut, Germany, 02747
        • Praxis G. Taesler /ID# 145782
      • Hersbruck, Germany, 91217
        • Allmacher, Hersbruck, DE /ID# 125998
      • Hersbruck, Germany, 91217
        • PsoriSol Hautklinik GmbH /ID# 169690
      • Herten, Germany, 45699
        • Kroemer, Herten, DE /ID# 48448
      • Heusenstamm, Germany, 63150
        • Badacz, Heusenstamm, DE /ID# 125999
      • Heusenstamm, Germany, 63150
        • Biedenkapp, Heusenstamm, DE /ID# 81275
      • Hilden, Germany, 40721
        • Stark & Stark, Hilden, DE /ID# 35470
      • Hilden, Germany, 40723
        • Klinken, Hilden, DE /ID# 33829
      • Hofgeismar, Germany, 34369
        • Kubek, Hofgeismar, DE /ID# 67963
      • Hofheim, Germany, 65719
        • Lenz, Hofheim, DE /ID# 33839
      • Hofheim Am Taunus, Germany, 65719
        • Praxis Dr. Brill /ID# 145764
      • Holzminden, Germany, 37603
        • Reinecke, Holzminden, DE /ID# 48464
      • Homburg, Germany, 66424
        • Franke, Homburg, DE /ID# 99821
      • Homburg, Germany, 66424
        • Univ Kliniken des Saarlandes /ID# 33848
      • Hoyerswerda, Germany, 02977
        • Nawka, Pistrosch, Hoyerswerda /ID# 81299
      • Hoyerswerda, Germany, 02977
        • Wolz/Bierbaum, Hoyerswerda, DE /ID# 48531
      • Ilmenau, Germany, 98693
        • Christoph, Ilmenau, DE /ID# 67949
      • Ingolstadt, Germany, 85049
        • Lutz, Ingolstadt, DE /ID# 35477
      • Ingolstadt, Germany, 85049
        • Stockmeier, Ingoldstadt, DE /ID# 53722
      • Ingolstadt, Germany, 85049
        • Tuttner, Ingoldstadt, DE /ID# 53726
      • Ingolstadt, Germany, 85057
        • Gfesser, Ingolstadt, DE /ID# 81277
      • Ingolstadt, Germany, 85057
        • Pueschel, Ingolstadt, DE /ID# 33859
      • Jena, Germany, 07747
        • Universitaetsklinikum Jena /ID# 138198
      • Juelich, Germany, 52428
        • Brilon & Zanker, Juelich, DE /ID# 33943
      • Juelich, Germany, 52428
        • Brilon & Zanker, Juelich, DE /ID# 60614
      • Kamen, Germany, 59174
        • Gaehtgens, Kamen, DE /ID# 67955
      • Kamenz, Germany, 01917
        • Thomas & Heike Mauer,Kamenz,DE /ID# 35480
      • Karlsruhe, Germany, 76133
        • Dres. Bettinger & Kollegen /ID# 138185
      • Karlsruhe, Germany, 76133
        • Meyer-Rogge & Kollegen /ID# 72013
      • Karlsruhe, Germany, 76133
        • Meyer-Rogge & Kollegen /ID# 99841
      • Karlsruhe, Germany, 76133
        • Reitenbach-Blindt,Karlsruhe,DE /ID# 48466
      • Karlsruhe, Germany, 76149
        • Glutsch, Karlsruhe, DE /ID# 33953
      • Karlsruhe, Germany, 76227
        • Eichbauer, Karlsruhe, DE /ID# 126017
      • Karlsruhe, Germany, 76227
        • Eichbauer, Karlsruhe, DE /ID# 60592
      • Karlstadt, Germany, 97753
        • Dunkel, Karlstadt, DE /ID# 50822
      • Kassel, Germany, 34117
        • Fueller, Kassel, DE /ID# 67953
      • Kassel, Germany, 34117
        • Medikum MVZ GmbH /ID# 148248
      • Kassel, Germany, 34117
        • Meyer & Baum, Kassel, DE /ID# 108916
      • Kassel, Germany, 34117
        • Meyer & Baum, Kassel, DE /ID# 50785
      • Kiel, Germany, 24105
        • Kreiselmaier, Kiel, DE /ID# 81298
      • Kleinmachnow, Germany, 14532
        • Klee/Radeck, Kleinmachnow, DE /ID# 33982
      • Kleve, Germany, 47533
        • Giesen, Kleve, DE /ID# 50825
      • Kleve, Germany, 47533
        • Grosse, Kleve, DE /ID# 33983
      • Koblenz, Germany, 56068
        • Grossmann, Koblenz, DE /ID# 99835
      • Koblenz, Germany, 56068
        • Habermann, Koblenz, DE /ID# 35488
      • Koenigs Wusterhausen, Germany, 15711
        • Blisse, Koenigs Wusterhausen, /ID# 33999
      • Koenigs Wusterhausen, Germany, 15711
        • Gruner, Koenigs Wusterhausen, /ID# 33998
      • Krefeld, Germany, 47798
        • Hetzer/Schuster/Prothmann /ID# 138200
      • Krefeld, Germany, 47798
        • Hetzer/Schuster/Prothmann /ID# 50860
      • Krefeld, Germany, 47799
        • Gerhards, Krefeld, DE /ID# 108915
      • Krefeld, Germany, 47802
        • Sauer/Wolff/Kreiss, Krefeld, D /ID# 141546
      • Krefeld, Germany, 47802
        • Sauer/Wolff/Kreiss, Krefeld, D /ID# 35242
      • Krefeld, Germany, 47802
        • Sauer/Wolff/Kreiss, Krefeld, D /ID# 53705
      • Krumbach, Germany, 86381
        • Praxis Dres. Hartschuh/Sugar-B /ID# 167674
      • Krumbach, Germany, 86381
        • Sugar-Bunk, Krumbach, DE /ID# 34085
      • Kulmbach, Germany, 95326
        • Dres. Jacobs & Kollegen /ID# 149402
      • Kusel, Germany, 66869
        • Schmidt, Kusel, DE /ID# 60609
      • Landau, Germany, 76829
        • Fritz/Biwer/Scherer/Uhlig /ID# 149401
      • Landshut, Germany, 84028
        • Huppmann, Landshut, DE /ID# 72017
      • Landshut, Germany, 84028
        • Jacoby, Landshut, DE /ID# 34089
      • Langenfeld, Germany, 40764
        • Janecka, Langenfeld, DE /ID# 34090
      • Langenhagen, Germany, 30853
        • Glockemann/Vennemann, Langenha /ID# 34091
      • Langenhagen, Germany, 30853
        • Glockemann/Vennemann, Langenha /ID# 53728
      • Langenselbold, Germany, 63505
        • Praxis. C. Nitzschner /ID# 142001
      • Lauda-konigshofen, Germany, 97922
        • Praxis Dr. Juttner /ID# 169691
      • Lauf, Germany, 91207
        • Riebel & Meckl & Goetz, Lauf /ID# 34093
      • Laupheim, Germany, 88471
        • Schunter, Laupheim, DE /ID# 35247
      • Lauterbach, Germany, 36341
        • Biedermann-Hahn, Lauterbach,DE /ID# 48416
      • Lehrte, Germany, 31275
        • Wirbel, Lehrte, DE /ID# 53730
      • Leipzig, Germany, 04289
        • Noack-Wiemers, Leipzig, DE /ID# 35248
      • Leipzig, Germany, 04329
        • Gruenenwald, Leipzig, DE /ID# 60595
      • Leipzig, Germany, 4209
        • Neubauer, Leipzig, DE /ID# 34103
      • Lengenfeld, Germany, 8485
        • Adler, Lengenfeld, DE /ID# 34115
      • Leonberg, Germany, 71229
        • Ogger & Gueldner-Engelmann /ID# 48455
      • Leverkusen, Germany, 51371
        • Onsa, Leverkusen, DE /ID# 90976
      • Lichtenfels, Germany, 96215
        • Praxis Dr. Carl /ID# 148247
      • Limburg, Germany, 65549
        • Dielmann, Limburg, DE /ID# 34124
      • Lingen, Germany, 49809
        • Vehring/Amann/Beier,Lingen,DE /ID# 35251
      • Lippstadt, Germany, 59555
        • Schuermeyer-Horst, Lippstadt, /ID# 34126
      • Lippstadt, Germany, 59557
        • Grodzki & Pier, Lippstadt, DE /ID# 34128
      • Lippstadt, Germany, 59557
        • Grodzki & Pier, Lippstadt, DE /ID# 48523
      • Loebau, Germany, 02708
        • Lochno, Loebau, DE /ID# 50843
      • Loehne, Germany, 32584
        • Hagemeier, Loehne, DE /ID# 35256
      • Luckenwalde, Germany, 14943
        • Ifflaender, Luckenwalde, DE /ID# 50828
      • Ludwigsfelde, Germany, 14974
        • Schultz, Ludwigsfelde, DE /ID# 50859
      • Ludwigshafen, Germany, 67059
        • Boehm & Boehm, Ludwigshafen /ID# 35263
      • Ludwigshafen, Germany, 67061
        • Wiest/Meng, Ludwigshafen, DE /ID# 138196
      • Ludwigshafen, Germany, 67063
        • Klinikum Stadt Ludwigshafen/Rh /ID# 34131
      • Luebeck, Germany, 23558
        • Kreusch/Krengel/Mrowka, Luebec /ID# 148411
      • Luebeck, Germany, 23562
        • Thierfelder, Luebeck, DE /ID# 34132
      • Luedenscheid, Germany, 58507
        • Dlugosz-Wolf, Luedenscheid, DE /ID# 81276
      • Luedenscheid, Germany, 58511
        • Praxis Dr. Bause /ID# 167670
      • Luedinghausen, Germany, 59348
        • Praxis Ch. Nolting-Schraeer /ID# 141548
      • Lueneburg, Germany, 21335
        • Birkner-Porath, Lueneburg, DE /ID# 90959
      • Lunen, Germany, 44534
        • Praxis C. Besser /ID# 141988
      • Lüdenscheid, Germany, 58515
        • Maerkische Kliniken GmbH /ID# 48512
      • Magdeburg, Germany, 39104
        • Bruecher, Magdeburg, DE /ID# 126000
      • Magdeburg, Germany, 39104
        • Grasshoff, Magdeburg, DE /ID# 34144
      • Magdeburg, Germany, 39104
        • Praxis Dr. Kuehne /ID# 145773
      • Magdeburg, Germany, 39108
        • Genseke/Krause, Magdeburg, DE /ID# 149288
      • Magdeburg, Germany, 39108
        • Kuchheuser, Magdeburg, DE /ID# 34143
      • Magdeburg, Germany, 39120
        • Otto von Guericke Universitaet /ID# 48435
      • Magdeburg, Germany, 39120
        • Otto von Guericke Universitaet /ID# 60588
      • Mahlow, Germany, 15831
        • Drs Scholz/Sebastian/Schilling /ID# 35273
      • Mainz, Germany, 55131
        • Univ Johannes Gutenberg /ID# 35662
      • Mannheim, Germany, 68161
        • Knuechel, Mannheim, DE /ID# 48440
      • Mannheim, Germany, 68161
        • Richter & Schernitzky,Mannheim /ID# 34183
      • Markdorf, Germany, 88677
        • Fuchs, Markdorf, DE /ID# 90973
      • Markkleeberg, Germany, 4416
        • Schulze/Schulze, Markkleeberg, /ID# 34188
      • Maxdorf, Germany, 67133
        • Maassen, Maxdorf, DE /ID# 34197
      • Meinerzhagen, Germany, 58540
        • Cymorek, Meinerzhagen, DE /ID# 48511
      • Meissen, Germany, 01662
        • Werner, Meissen, DE /ID# 81318
      • Memmingen, Germany, 87700
        • Schwinn & Winkler,Memmingen,DE /ID# 35281
      • Menden, Germany, 58706
        • Moeller-Massling & Wippermann /ID# 48529
      • Minden, Germany, 32423
        • Klinikum Minden /ID# 34205
      • Minden, Germany, 32427
        • Boss, Minden, DE /ID# 145772
      • Moenchengladbach, Germany, 41061
        • Kantner, Moenchengladbach, DE /ID# 99836
      • Moenchengladbach, Germany, 41061
        • Zentbeauty Gbr /ID# 72020
      • Moenchengladbach, Germany, 41199
        • Stroemer & Deden /ID# 48502
      • Moenchengladbach, Germany, 41236
        • Dorittke & Kardorff /ID# 35289
      • Muehlhausen, Germany, 99974
        • Mang, Muehlhausen, DE /ID# 48451
      • Muehlheim, Germany, 63165
        • Kaufmann, Muehlheim, DE /ID# 60603
      • Muelheim, Germany, 45468
        • Nikodem-Koczwara, Muelheim, DE /ID# 53710
      • Muelheim, Germany, 45468
        • Schueller, Muelheim a.d. Ruhr /ID# 126025
      • Muenster, Germany, 48143
        • Habenicht/Marth, Muenster, DE /ID# 138190
      • Muenster, Germany, 48143
        • Mueller, Muenster, DE /ID# 53709
      • Munich, Germany, 80333
        • Husemann & Fischer, Munich, DE /ID# 53692
      • Munich, Germany, 80469
        • Malmusi, Munich, DE /ID# 48450
      • Munich, Germany, 80634
        • Anders-Ankerhold, Munich, DE /ID# 53682
      • Munich, Germany, 80802
        • Klinikum recht der Isar der TU /ID# 138208
      • Munich, Germany, 80802
        • Pfannenstiel, Munich, DE /ID# 126023
      • Munich, Germany, 80802
        • TU Uniklinik Munchen /ID# 202198
      • Munich, Germany, 81373
        • Gagel, Munich, DE /ID# 60593
      • Munich, Germany, 81379
        • Keilig, Munich, DE /ID# 53702
      • Munich, Germany, 81539
        • Quack, Munich, DE /ID# 53715
      • Munster, Germany, 48155
        • Lissner, Auerbach, DE /ID# 35061
      • Naumburg, Germany, 06618
        • Wilhelm, Naumburg, DE /ID# 67970
      • Neubrandenburg, Germany, 17034
        • Paech, Neubrandenburg, DE /ID# 34057
      • Neufahrn, Germany, 85375
        • Bruckbauer, Neufahrn, DE /ID# 48418
      • Neugersdorf, Germany, 2727
        • Franke, Neugersdorf, DE /ID# 138187
      • Neumarkt, Germany, 92318
        • Meisel-Stosiek, Neumarkt, DE /ID# 34067
      • Neumarkt, Germany, 92318
        • Schwerbrock, Neumarkt, DE /ID# 34068
      • Neumuenster, Germany, 24534
        • Buettner & Meewes,Neumuenster /ID# 35310
      • Neustadt, Germany, 90443
        • von Kobyletzki, Nuernberg, DE /ID# 35315
      • Neustrelitz, Germany, 17235
        • Sperling, Neustrelitz, DE /ID# 53721
      • Neuwied, Germany, 56564
        • Kloos & Loeser, Neuwied, DE /ID# 35318
      • Neuwied, Germany, 56564
        • Kloos & Loeser, Neuwied, DE /ID# 35319
      • Nieder-olm, Germany, 55268
        • Boeckers, Nieder-Olm, DE /ID# 138262
      • Norden, Germany, 26506
        • Mahlke, Norden, DE /ID# 99840
      • Norderney, Germany, 26548
        • Krankenhaus Norderney /ID# 72021
      • Norderstedt, Germany, 22846
        • Praxis S. Zajac /ID# 148245
      • Norderstedt, Germany, 22850
        • Gutgesell, Norderstedt, DE /ID# 34159
      • Nordhausen, Germany, 99734
        • Niemeyer, Nordhausen, DE /ID# 35323
      • Nordhausen, Germany, 99734
        • Wienrich, Nordhausen, DE /ID# 126029
      • Nuernberg, Germany, 90482
        • Praxis Dr.S.Vogel- Kiener /ID# 167679
      • Nuremberg, Germany, 90408
        • Thuencher, Nuremberg, DE /ID# 34163
      • Nuremberg, Germany, 90419
        • Voelkel, Nuremberg, DE /ID# 34164
      • Nuremberg, Germany, 90451
        • Tuerk, Nuremberg, DE /ID# 67968
      • Nuremberg, Germany, 90482
        • Vogel/Walther, Nuremberg, DE /ID# 67969
      • Nuremberg, Germany, 90491
        • Alpagut & Alpagut & Meisel /ID# 35325
      • Oberhausen, Germany, 46045
        • HELIOS St. Elisabeth Klinik /ID# 138263
      • Oberhausen, Germany, 46117
        • Saleh, Oberhausen, DE /ID# 138201
      • Oberhausen, Germany, 46147
        • Rudolphi/Duckheim, Oberhausen, /ID# 34169
      • Oberschleissheim, Germany, 85764
        • Ponce de Poeschl, Oberschleiss /ID# 53714
      • Oelde, Germany, 59302
        • Hockmann, Oelde, DE /ID# 48515
      • Oelsnitz, Germany, 09376
        • Wendrock-Shiga, Oelsnitz, DE /ID# 35328
      • Oer-erkenschwick, Germany, 45739
        • Altmeyer, Oer-Erkenschwick, DE /ID# 50783
      • Offenbach, Germany, 63067
        • Praxis Dr. Spreng /ID# 145780
      • Oldenburg, Germany, 26122
        • Fechner/Addicks, Oldenburg, DE /ID# 60582
      • Oldenburg, Germany, 26123
        • Reinicke, Oldenburg, DE /ID# 126024
      • Oldenburg, Germany, 26133
        • Klinikum Oldenburg GmbH /ID# 50848
      • Oldenburg, Germany, 26133
        • Klinikum Oldenburg GmbH /ID# 50854
      • Olpe, Germany, 57462
        • MVZ Olpe I /ID# 167678
      • Olpe, Germany, 57462
        • Reipen, Olpe, DE /ID# 48524
      • Ormond Beach, Germany, 32174
        • Fachklinik Bad Bentheim /ID# 35568
      • Oschatz, Germany, 04758
        • Praxis C. Bochenek /ID# 167671
      • Osnabrueck, Germany, 49074
        • Breitsprecher, Osnabrueck, DE /ID# 35330
      • Osnabrueck, Germany, 49076
        • Klinikum Osnabrueck GmbH /ID# 35332
      • Osnabrueck, Germany, 49078
        • Rosenbach, Osnabrueck, DE /ID# 33497
      • Pasewalk, Germany, 17309
        • Hoppe, Pasewalk, DE /ID# 53699
      • Peitz, Germany, 03185
        • Kuehn, Peitz, DE /ID# 33510
      • Philippsburg, Germany, 76661
        • Baumann, Philippsburg, DE /ID# 33518
      • Phoenix, Germany, 85014
        • Staender, Bad Bentheim, DE /ID# 35522
      • Pinneberg, Germany, 25421
        • Itschert, Pinneberg, DE /ID# 67958
      • Pirna, Germany, 01796
        • Schmidt, Pirna, DE /ID# 48525
      • Plettenberg, Germany, 58840
        • Kallweit, Plettenberg, DE /ID# 53701
      • Porta Westfalica, Germany, 32457
        • Farzar/Kramer/Mohme, Porta /ID# 33530
      • Porta Westfalica, Germany, 32457
        • Farzar/Kramer/Mohme, Porta /ID# 99845
      • Potsdam, Germany, 14467
        • Buehler/Radke, Potsdam, DE /ID# 33531
      • Potsdam, Germany, 14469
        • Hautarztpraxis am Stadthaus /ID# 141997
      • Potsdam, Germany, 14469
        • Hautarztpraxis am Stadthaus /ID# 149287
      • Potsdam, Germany, 14471
        • Asadullah/Gross, Potsdam, DE /ID# 72014
      • Potsdam, Germany, 14480
        • Luedcke, Potsdam, DE /ID# 33462
      • Potsdam, Germany, 14480
        • Praxis Dr. Barbu /ID# 156481
      • Preetz, Germany, 24211
        • MARE Klinikum /ID# 33473
      • Pruem, Germany, 54595
        • Akst, Pruem, DE /ID# 33477
      • Puettlingen, Germany, 66346
        • John&Rupp-John, Puettlingen,DE /ID# 35342
      • Pulheim, Germany, 50259
        • Kirchesch, Pulheim, DE /ID# 50830
      • Quedlinburg, Germany, 06484
        • Klin Christiane Erxleben GmbH /ID# 35344
      • Radebeul, Germany, 01445
        • Frank/Frank, Radebeul, DE /ID# 138186
      • Radolfzell, Germany, 78315
        • Rozsondai, Radolfzell, DE /ID# 50857
      • Rastatt, Germany, 76437
        • Gehse, Rastatt, DE /ID# 67956
      • Rastatt, Germany, 76437
        • Parker, Rastatt, DE /ID# 48522
      • Recklinghausen, Germany, 45661
        • Praxis Dres. Pierchalla & Part /ID# 151478
      • Regensburg, Germany, 93042
        • Klinikum Univ Regensburg /ID# 33894
      • Regensburg, Germany, 93049
        • Haueisen, Regensburg, DE /ID# 81296
      • Rehau, Germany, 95111
        • Kluge & Ott, Rehau, DE /ID# 33895
      • Reichenbach, Germany, 08468
        • Weis, Reichenbach, DE /ID# 138204
      • Remscheid, Germany, 42897
        • Kramer/Mortazawi, Remscheid /ID# 33898
      • Rendsburg, Germany, 24768
        • Haut-und Allergie-Ambulatorium /ID# 148250
      • Rheinbach, Germany, 53359
        • Montag, Rheinbach, DE /ID# 99846
      • Rheine, Germany, 48429
        • Ludwig, Rheine, DE /ID# 50846
      • Rheinstetten, Germany, 76287
        • Manuel, Rheinstetten, DE /ID# 33908
      • Ribnitz-damgarten, Germany, 18311
        • Maslen & Pavlovsky, Ribnitz /ID# 35353
      • Riesa, Germany, 01587
        • Krausse, Riesa, DE /ID# 35357
      • Rinteln, Germany, 31737
        • Krausch, Rinteln, DE /ID# 48447
      • Rostock, Germany, 18055
        • Kleditzsch/Blank, Rostock, DE /ID# 60587
      • Rostock, Germany, 18059
        • Buttler, Rostock, DE /ID# 60590
      • Rostock, Germany, 18059
        • Hoene, Rostock, DE /ID# 48516
      • Rostock, Germany, 18107
        • Slucka, Rostock, DE /ID# 126026
      • Rostock, Germany, 18109
        • Goeldner, Rostock, DE /ID# 33919
      • Rostock, Germany, 18146
        • Bomke, Rostock, DE /ID# 99816
      • Rottweil, Germany, 78628
        • Eisfelder, Rottweil, DE /ID# 34010
      • Rudolstadt, Germany, 07407
        • Prifert, Rudolstadt, DE /ID# 35359
      • Rudolstadt, Germany, 7407
        • Zapf, Rudolstadt, DE /ID# 34011
      • Saalfeld, Germany, 7318
        • Hempel, Saalfeld, DE /ID# 34013
      • Saarlouis, Germany, 66740
        • Trennheuser % Hasselmann /ID# 34018
      • Saint Wendel, Germany, 66606
        • Salzmann, St. Wendel, DE /ID# 33579
      • Sangerhausen, Germany, 6526
        • Spitzbarth, Sangerhausen, DE /ID# 34028
      • Schleiz, Germany, 7907
        • Broening, Schleiz, DE /ID# 35366
      • Schmoelln, Germany, 04626
        • Durrant-Finn, Schmoelln, DE /ID# 67950
      • Schneeberg, Germany, 8289
        • Alscher, Schneeberg, DE /ID# 35368
      • Schorndorf, Germany, 73614
        • Gueldner, Schorndorf, DE /ID# 33536
      • Schwandorf, Germany, 92421
        • Frankerl, Schwandorf, DE /ID# 33543
      • Schwarzenberg, Germany, 08340
        • Mueller, Schwarzenberg, DE /ID# 138197
      • Schwedt, Germany, 16303
        • Asklepios Klin Uckermark /ID# 35373
      • Schweina, Germany, 36448
        • Huyke, Schweina, DE /ID# 138193
      • Schweinfurt, Germany, 97421
        • Mehringer, Schweinfurt, DE /ID# 50850
      • Schwelm, Germany, 58332
        • Fraenken/Leksa, Schwelm, DE /ID# 33547
      • Selters, Germany, 56242
        • von Kiedrowski, Selters, DE /ID# 33560
      • Siegen, Germany, 57072
        • David, Siegen, DE /ID# 148242
      • Siegen, Germany, 57072
        • David, Siegen, DE /ID# 99817
      • Simmern, Germany, 55469
        • Asefi, Simmern, DE /ID# 67945
      • Singen, Germany, 78224
        • Albig, Singen, DE /ID# 33564
      • Soemmerda, Germany, 99610
        • Wendler, Soemmerda, DE /ID# 138205
      • Soest, Germany, 59494
        • Hagemann, Soest, DE /ID# 48514
      • Soest, Germany, 59494
        • Karl, Soest, DE /ID# 33569
      • Soest, Germany, 59494
        • Thiele, Soest, DE /ID# 33568
      • Spaichingen, Germany, 78549
        • Wroblewska, Spaichingen, DE /ID# 34867
      • Spremberg, Germany, 03130
        • Zobel, Spremberg, DE /ID# 50869
      • Starnberg, Germany, 82319
        • Blecher, Starnberg, DE /ID# 33589
      • Stassfurt, Germany, 39418
        • Bange, Stassfurt, DE /ID# 48510
      • Straubing, Germany, 94315
        • Steinborn, Straubing, DE /ID# 33594
      • Stuttgart, Germany, 70174
        • Cavcic, Stuttgart, DE /ID# 126015
      • Stuttgart, Germany, 70178
        • Leitz, Stuttgart, DE /ID# 126018
      • Stuttgart, Germany, 70178
        • Leitz, Stuttgart, DE /ID# 72023
      • Stuttgart, Germany, 70374
        • Bauer, Stuttgart, DE /ID# 53683
      • Stuttgart, Germany, 70567
        • Flegl MD Stuttgart Germany /ID# 50824
      • Suhl, Germany, 98527
        • Praxis. Dr. Koehler /ID# 142000
      • Sulzbach, Germany, 66280
        • Jager/Landwehr, Sulzbach, DE /ID# 33615
      • Sulzbach-rosenberg, Germany, 92237
        • Krusche&Mai,Sulzbach-Rosenberg /ID# 33616
      • Telgte, Germany, 48291
        • Kirchhoff, Telgte, DE /ID# 50831
      • Teltow, Germany, 14513
        • Lueg, Teltow, DE /ID# 33617
      • Teterow, Germany, 17166
        • Cyrulies, Teterow, DE /ID# 33621
      • Tirschenreuth, Germany, 95643
        • Frank, Tirschenreuth, DE /ID# 33622
      • Tornesch, Germany, 25436
        • Meyer, Tornesch, DE /ID# 33626
      • Traunstein, Germany, 83278
        • Pleier/Weidenbach, Traunstein, /ID# 33627
      • Trier, Germany, 54290
        • Brisch, Trier, DE /ID# 60589
      • Tuebingen, Germany, 72076
        • Universitatsklinikum Tubingen /ID# 33631
      • Tuebingen, Germany, 72076
        • Universitatsklinikum Tubingen /ID# 81278
      • Ueberlingen, Germany, 88662
        • Braun, Ueberlingen, DE /ID# 33638
      • Unna, Germany, 59423
        • Winkler-Gyulay, Unna, DE /ID# 48528
      • Varel, Germany, 26316
        • Giesenberg, Varel, DE /ID# 33728
      • Varel, Germany, 26316
        • Loetzsch, Varel, DE /ID# 50845
      • Vechta, Germany, 49377
        • Jasnoch/Kock/Borrosch, Vechta, /ID# 145770
      • Vechta, Germany, 49377
        • Jasnoch/Kock/Borrosch, Vechta, /ID# 33730
      • Vechta, Germany, 49377
        • Jasnoch/Kock/Borrosch, Vechta, /ID# 60605
      • Viersen, Germany, 41747
        • Steiner, Viersen, DE /ID# 141547
      • Viersen, Germany, 41747
        • Steiner, Viersen, DE /ID# 99848
      • Villingen-schwenningen, Germany, 78050
        • Praxis Dr. Czech /ID# 145765
      • Vilshofen, Germany, 94474
        • Fischer, Vilshofen, DE /ID# 148252
      • Vilshofen, Germany, 94474
        • Fischer, Vilshofen, DE /ID# 50823
      • Wadern, Germany, 66687
        • Foss, Wadern, DE /ID# 33738
      • Waltershausen, Germany, 99880
        • Barnikol, Waltershausen, DE /ID# 35401
      • Waltrop, Germany, 45731
        • Funke, Waltrop, DE /ID# 33739
      • Wedel, Germany, 22880
        • Hoos, Wedel, DE /ID# 33745
      • Wegberg, Germany, 41844
        • Billmann-Krutmann, Wegberg, DE /ID# 90958
      • Weiden, Germany, 92637
        • Pausch, Weiden, DE /ID# 60606
      • Weimar, Germany, 99423
        • Reindl, Weimar, DE /ID# 60607
      • Weissenfels, Germany, 06667
        • Asklepios Krankenh Weissenfels /ID# 138206
      • Weissenfels, Germany, 06667
        • Fiedler, Weissenfels, DE /ID# 33752
      • Werdau, Germany, 08412
        • Pfennig, Werdau, DE /ID# 48459
      • Werl, Germany, 59457
        • Roehrborn, Werl, DE /ID# 33754
      • Werne, Germany, 59368
        • Dr. Barbara Kempkes, Werne /ID# 118540
      • Wesel, Germany, 46485
        • Jansen & Weersch, Wesel, DE /ID# 33756
      • Wesseling, Germany, 50389
        • Schmeel, Wesseling, DE /ID# 81303
      • Wetter, Germany, 58300
        • Uszynska-Jast, Wetter, DE /ID# 33758
      • Wetzlar, Germany, 35578
        • Kaempfer, Wetzlar, DE /ID# 33759
      • Wetzlar, Germany, 35578
        • Paul, Wetzlar, DE /ID# 50855
      • Wiesbaden, Germany, 65185
        • Moeller, Wiesbaden, DE /ID# 50852
      • Wiesmoor, Germany, 26639
        • Hasselbusch, Wiesmoor, DE /ID# 33766
      • Wildau, Germany, 15745
        • Buttgereit/Stiller, Wildau, DE /ID# 33767
      • Wilhelmshaven, Germany, 26382
        • Hutschenreuther, Wilhelmshaven /ID# 33768
      • Wilhelmshaven, Germany, 26389
        • Gajda, Wilhelmshaven, DE /ID# 138261
      • Winsen (luhe), Germany, 21423
        • Maronde, Winsen, DE /ID# 53707
      • Wipperfuerth, Germany, 51688
        • Dr. Martin Gruener, Wipperfuer /ID# 118538
      • Witten, Germany, 58452
        • Klein, Witten, DE /ID# 33777
      • Witten, Germany, 58453
        • Hoffmann, Witten, DE /ID# 35417
      • Wittenberg, Germany, 6886
        • Merk, Lutherstadt Wittenberg, /ID# 126020
      • Wittlich, Germany, 54516
        • Suess, Wittlich, Germany /ID# 33629
      • Wittmund, Germany, 26409
        • Roos, Wittmund, DE /ID# 118542
      • Wittstock, Germany, 16909
        • Metz, Wittstock, DE /ID# 33781
      • Wolfenbuettel, Germany, 38300
        • Franz, Wolfenbuettel, DE /ID# 33782
      • Wolfenbuettel, Germany, 38300
        • Rowold, Wolfenbuettel, DE /ID# 48467
      • Wolmirstedt, Germany, 39326
        • Rinke, Wolmirstedt, DE /ID# 48532
      • Wuerzburg, Germany, 97070
        • Beilner-Tack, Wuerzburg, DE /ID# 67947
      • Wuerzburg, Germany, 97070
        • Schubert&Frank&Konrad&Eggert /ID# 33715
      • Wuerzburg, Germany, 97070
        • Schubert&Frank&Konrad&Eggert /ID# 48526
      • Wuerzburg, Germany, 97070
        • Schubert&Frank&Konrad&Eggert /ID# 67961
      • Wuerzburg, Germany, 97084
        • Hamm & Kinkelin, Wuerzburg, DE /ID# 33714
      • Wuppertal, Germany, 42103
        • Fuge-Dierking, Wuppertal, DE /ID# 33720
      • Wuppertal, Germany, 42103
        • Gleissner/Sadlo, Wuppertal, DE /ID# 108919
      • Wuppertal, Germany, 42103
        • Gleissner/Sadlo, Wuppertal, DE /ID# 48434
      • Wuppertal, Germany, 42105
        • Huebinger, Wuppertal, DE /ID# 53700
      • Wuppertal, Germany, 42275
        • Praxis Dr. Schock-Skasa /ID# 148246
      • Wuppertal, Germany, 42369
        • Bartenberg, Wuppertal, DE /ID# 81273
      • Wurzen, Germany, 04808
        • Albrecht, Wurzen, DE /ID# 35422
      • Zehdenick, Germany, 16792
        • Franz-Reichel, Zehdenick, DE /ID# 33860
      • Zeulenroda, Germany, 07937
        • Weber, Zeulenroda, DE /ID# 50867
      • Zschopau, Germany, 9405
        • Rudolph, Zschopau, DE /ID# 166129
      • Zschopau, Germany, 9405
        • Rudolph, Zschopau, DE /ID# 35424
      • Zwickau, Germany, 08056
        • Mischke, Zwickau, DE /ID# 35430
      • Zwickau, Germany, 08060
        • Heinrich Braun Klinik Zwickau /ID# 50849
      • Zwickau, Germany, 08066
        • Mende-Dietz, Zwickau, DE /ID# 35426
      • Zwickau, Germany, 8056
        • Praxis MVZ Gefaesszentrum Zwic /ID# 145766
      • Zwickau, Germany, 8058
        • Gebhardt, Zwickau, DE /ID# 35432
      • Zwickau, Germany, 8060
        • Junghaenel, Zwickau, DE /ID# 35428
    • Baden-Wuerttemberg
      • Heidelberg, Baden-Wuerttemberg, Germany, 69120
        • Universitaetsklinik Heidelberg /ID# 33810
      • Heidelberg, Baden-Wuerttemberg, Germany, 69120
        • Universitaetsklinik Heidelberg /ID# 50858
      • Mannheim, Baden-Wuerttemberg, Germany, 68167
        • Universitatsklinikum Mannheim /ID# 166130
    • Bayern
      • Erlangen, Bayern, Germany, 91054
        • Universitaetsklinikum Erlangen /ID# 34816
    • Hessen
      • Frankfurt am Main, Hessen, Germany, 60590
        • Universitätsklinikum Frankfurt /ID# 53725
    • Niedersachsen
      • Munster, Niedersachsen, Germany, 48149
        • Universitatsklinikum Munster /ID# 205840
      • Munster, Niedersachsen, Germany, 48149
        • Universitatsklinikum Munster /ID# 72018
      • Munster, Niedersachsen, Germany, 48149
        • Universitatsklinikum Munster /ID# 72022
    • Nordrhein-Westfalen
      • Aachen, Nordrhein-Westfalen, Germany, 52062
        • Praxis M. Vilic /ID# 210108
      • Aachen, Nordrhein-Westfalen, Germany, 52074
        • Universitaetsklinikum Aachen /ID# 35037
      • Köln, Nordrhein-Westfalen, Germany, 50937
        • Uniklinik Koln /ID# 166128
      • Münster, Nordrhein-Westfalen, Germany, 48147
        • Hautarztpraxis am Buddenturm /ID# 205094
    • Sachsen
      • Dresden, Sachsen, Germany, 01307
        • Praxis Dr. Büchner /ID# 204352
      • Leipzig, Sachsen, Germany, 04103
        • Universitaetsklinikum Leipzig /ID# 53720
      • Pirna, Sachsen, Germany, 01796
        • Praxis Dr. Reimann /ID# 142004
    • Schleswig-Holstein
      • Kiel, Schleswig-Holstein, Germany, 24103
        • Praxis N. Yenigün /ID# 206670
      • Kiel, Schleswig-Holstein, Germany, 24105
        • Univ Hosp Schleswig-Holstein /ID# 33981
      • Kiel, Schleswig-Holstein, Germany, 24105
        • Univ Hosp Schleswig-Holstein /ID# 35269
      • Kiel, Schleswig-Holstein, Germany, 24148
        • Medizinisches Versorgungszentrum DermaKiel GmbH /ID# 33972

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

16 years to 97 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Community Sample: Patients with Plaque Psoriasis

Description

Inclusion Criteria:

- Moderate to severe plaque psoriasis in adults with no response to other systemic therapy (e.g. cyclosporine, methotrexate or PUVA (photochemical therapy)) or patients with a contraindication or hypersensitivity to such a therapy

Exclusion Criteria:

- Hypersensitivity against the drug or one of the other ingredients; active tuberculosis or other severe infections (e.g. sepsis and opportunistic infections); moderate to severe cardiac insufficiency

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Only
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
Psoriasis Patients
Patients with moderate to severe plaque psoriasis

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Changes in Psoriasis Area and Severity Index; number of patients with Psoriasis Area and Severity Index-75 reduction.
Time Frame: At 24, 48 and 60 months
At 24, 48 and 60 months
Changes in healthcare parameters: number of missed working days due to psoriasis; number of visits at the doctor's office; number and duration of hospitalizations, self-assessed workability.
Time Frame: At 24, 48 and 60 months
At 24, 48 and 60 months
Safety and tolerability assessed by analyzing serious and non-serous adverse events.
Time Frame: At 24, 48 and 60 months
At 24, 48 and 60 months

Secondary Outcome Measures

Outcome Measure
Time Frame
Global physician's assessment on Humira treatment.
Time Frame: At 24, 48 and 60 months
At 24, 48 and 60 months
Target Nail Psoriasis Severity Index (target NAPSI).
Time Frame: At 24 months
At 24 months
Itch Visual Analogue Scale (Itch VAS).
Time Frame: At 24 months
At 24 months
Safety and tolerability of Humira - treatment for patient groups with frequent concommitant diseases, especially diabetes type I and II, cardio-vascular and liver and kidney functional impairment and respective concommitant medication.
Time Frame: At 24, 48 and 60 months
At 24, 48 and 60 months
Palmoplantar Psoriasis Area Severity Index (pPASI).
Time Frame: At 24 months
At 24 months
Influence of body mass index and weight on efficacy measurement.
Time Frame: At 24, 48 and 60 months
At 24, 48 and 60 months
Patients' assessment on Humira treatment.
Time Frame: At 24, 48 and 60 months
At 24, 48 and 60 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 4, 2008

Primary Completion (Actual)

June 30, 2019

Study Completion (Actual)

June 30, 2019

Study Registration Dates

First Submitted

February 25, 2010

First Submitted That Met QC Criteria

February 25, 2010

First Posted (Estimate)

March 1, 2010

Study Record Updates

Last Update Posted (Actual)

June 12, 2020

Last Update Submitted That Met QC Criteria

June 11, 2020

Last Verified

June 1, 2020

More Information

Terms related to this study

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

Undecided

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Moderate to Severe Plaque Psoriasis

Subscribe