Effects of Training in Healthy Sedentary Subjects

September 3, 2012 updated by: 5 Santé

Cellular Effects of Training in Healthy Sedentary Subjects

The purpose of this study is to understand underlying mechanisms of improved exercise tolerance in Healthy Sedentary Subjects after training program.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Training protocol used is based on recommendations. A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.

Study Type

Interventional

Enrollment (Actual)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Lodeve, France
        • Clinique du souffle La valonie
      • Montpellier, France
        • hopital Arnaud de Vilneuve
      • Osseja, France
        • Clinique du Souffle la Solane

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

50 years to 75 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • healthy Sedentary Subjects

Exclusion Criteria:

  • neuromuscular disease
  • chronic heart failure
  • diabetes
  • renal diseases
  • liver diseases

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Ventilatory threshold
Training at the ventilatory threshold
Other: Training
20 sessions of training
Other Names:
  • Vt
  • Mt
Active Comparator: Metabolic threshold
Training at the metabolic threshold
Other: Training
20 sessions of training
Other Names:
  • Vt
  • Mt

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Effects of training program on mitochondrial function and oxidative stress
Time Frame: 6 to 8 weeks
6 to 8 weeks

Secondary Outcome Measures

Outcome Measure
Time Frame
Relationship between mitochondrial function, oxidative stress and exercise tolerance in COPD patients
Time Frame: 6 to 8 weeks
6 to 8 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

5 Santé

Collaborators

Institut National de la Santé Et de la Recherche Médicale, France
Centre Hospitalier Régional Universitaire Montpellier

Investigators

  • Principal Investigator: Maurice MH Hayot, MCU-PH, Institut National de la Santé Et de la Recherche Médicale, France

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2008

Primary Completion (Actual)

December 1, 2010

Study Completion (Actual)

December 1, 2010

Study Registration Dates

First Submitted

August 16, 2010

First Submitted That Met QC Criteria

August 16, 2010

First Posted (Estimate)

August 17, 2010

Study Record Updates

Last Update Posted (Estimate)

September 5, 2012

Last Update Submitted That Met QC Criteria

September 3, 2012

Last Verified

September 1, 2012

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 2008-A00209-46

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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