To Investigate the Prevalence of Children Asthma in China

To Investigate the Prevalence of Children Asthma in China and Compare With That of the Last 20 Years

Asthma is the most common chronic respiratory disease in children and has much effect on their life and study, which leads to huge economic burden and pressure to the whole families. Some children will develop into adult patients so that asthma can be the life-long vigorous trouble. In recent years, the prevalence rate of children asthma is increasingly going up worldwide. The prevalence rate in last 12 months reported in USA, United Kingdom, Australia, New Zealand was between 12% to 30%.

Center for Asthma Prevention and Education of Capital Institute of Pediatrics investigated the national asthma prevalence in 900 thousands children in 27 provinces and cities, which average rate was 0.11% to 2.03% in 1990. In 2000, we investigated it again in 31 provinces(43 cities) and the average national children asthma prevalence rate was 1.97%(0.25% to 4.63%) which was much higher than that in 1990.

Study Overview

• Status: Completed
• Conditions: Asthma

Detailed Description

1. Objectives

   1. To investigate the national children(0-14 years old)asthma prevalence;
   2. To compare the prevalence rate between that in 1990 and 2000;
   3. To analyse the asthma manifestations including the ages, seasons, causes, trigger and hereditary factors and their impact on the asthma patients, families and society;
   4. To identify the risk factors by questionnaires in case-control research.

2. Study Design / Clinical Plan

   1. The screening stage: to distinguish suspected asthma from the children age from 0 to 14 years old.
   2. To obtain identified asthma from the suspected asthma.
   3. To evaluate the prevalence and severe degree of 0 to 14-year-old children asthma and gain the main risk factors by case-control research.

• Study Type: Observational
• Enrollment (Actual): 20000

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 14 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

children age from 0 to 14 years in big cities in China

Description

Inclusion Criteria:

• children age from 0 to 14 years

Exclusion Criteria:

• none

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Asthma children; children with asthma symptoms through screening
normal children; children without symptoms of asthma

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
prevalence of asthma	Apr 2013

Secondary Outcome Measures

Outcome Measure	Time Frame
prevalence of allergic rhinitis	Apr 2013

Collaborators and Investigators

• Sponsor: Capital Institute of Pediatrics, China
• Collaborators: Merck Sharp & Dohme LLC
• Investigators: Study Chair: YuZhi Chen, professor, Capital Institute of Pediatrics, China

Study record dates

Study Major Dates

• Study Start: April 1, 2011
• Primary Completion (Actual): April 1, 2013
• Study Completion (Actual): April 1, 2014

Study Registration Dates

• First Submitted: March 17, 2011
• First Submitted That Met QC Criteria: March 18, 2011
• First Posted (Estimate): March 21, 2011

Study Record Updates

• Last Update Posted (Estimate): August 4, 2014
• Last Update Submitted That Met QC Criteria: August 1, 2014
• Last Verified: August 1, 2014

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Immune System Diseases; Lung Diseases; Hypersensitivity, Immediate; Bronchial Diseases; Lung Diseases, Obstructive; Respiratory Hypersensitivity; Hypersensitivity; Asthma
• Other Study ID Numbers: MISP38877