- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01351142
Cytokines and Cognitive Decline in Alzheimer's Disease
Amyloid plaques and neurofibrillary tangles are the 2 well-known etiopathological hallmarks of Alzheimer's disease (AD). Beside these 2 lesions, inflammation response is described in the brain of patients with AD.
The main objective of our study is to analyse the correlation between the value of plasma cytokines (interleukin 1, 6, TNFα and chemochine Rantes) and the rapidity of the cognitive decline in AD over a 2-year follow-up.
Secondary objectives include:
- the predictive value of the cytokines on the cognitive decline after 6 months and one year of follow-up., of the patients include 150 patients with AD (MMSE: 16-25)
- correlation between plasma cytokines levels and expression of the protein kinase PKR (involved in death cell) in blood mononuclear cells.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Angers, France, 49933
- CHU Angers - service Gérontologie clinique
-
Limoges, France, MD
- Hôpital Dupuytren - CHU de Limoges
-
Nantes, France, 44000
- CHU de NANTES - service Gériatrie
-
Nantes, France, 44046
- CHU DE NANTES - Centre ambulatoire de Gérontologie clinique
-
Paris, France, 75651
- Hopital Pitie Salpetriere
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Paris, France, 75013
- Hôpital Broca - service de Gériatrie
-
Poitiers, France, 86021
- Chu de Poitiers -
-
Strasbourg, France, 67981
- CHU Strasbourg
-
Tours, France, 37044
- CHU de TOURS - service de Gériatrie
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Villeurbanne, France, 69100
- Hôpital gériatrique des Charpennes
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Alzheimer's disease (AD)patients
- MMSE score: 16-25
- Written informed consent
Exclusion Criteria:
- AD patients with specific treatment for AD before inclusion MMSE score under 16 or over 25 at inclusion
- patients with anti-inflammatory drugs (non steroids or corticosteroids) or immunosuppressive agents
- Patients with acute disease (infectious disease, rheumatologic disease) or chronic disease (malignancy, infectious, rheumatologic disease) that could interact with plasma cytokines level
- Patients with a life threatening disease
Study Plan
How is the study designed?
Design Details
- Allocation: N/A
- Interventional Model: Single Group Assignment
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CYTOCOGMA
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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