Rapid 10-Minute Liver MRI Protocol in Patients With Suspected Hepatocellular Carcinoma

Rapid 10-Minute Liver MRI Protocol in Patients With Suspected Hepatocellular Carcinoma: A Pilot Study to Assess the Image Quality (Multitransmit Body MRI Program)

The purpose of this study to assess the image quality of the rapid magnetic resonance imaging (MRI) compared to the standard MRI.

Study Overview

• Status: Completed
• Conditions: Hepatitis; Fibrosis of Liver; Underlying Liver Disease; Cirrhosis With Suspicion of Liver Cancer; Lesion on a Prior Ultrasound, CT or Outside MRI

Detailed Description

This is a pilot study to compare a rapid 10-minute liver magnetic resonance imaging (MRI) protocol to standard MRI in participants with suspected hepatocellular carcinoma.

• Study Type: Observational
• Enrollment (Actual): 25

Contacts and Locations

Study Locations

• United States
  • Nebraska
    • Omaha, Nebraska, United States, 68198
      • University of Nebraska Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 19 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

patients with an underlying liver disease

Description

Inclusion Criteria:

1. underlying liver disease
2. have a lesion on a prior imaging study
3. must have prior standard MR

Exclusion Criteria:

1. Contra-indication for MR imaging including pacemaker, claustrophobia, pregnancy, electronic or vascular devices that are contraindicated;
2. patients with severe kidney dysfunction

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
subjects with an underlying liver disease; (1)underlying liver disease; (2) have a lesion on a prior imaging study; (3) must be prior standard MR

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
image quality outcome	Two MRI exams will be evaluated by two radiologists based on a number of items.	2 years

Collaborators and Investigators

• Sponsor: University of Nebraska
• Collaborators: Bracco Diagnostics, Inc; Philips Medical Systems
• Investigators: Principal Investigator: Shahid Hussain, MD, University of Nebraska

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2011
• Primary Completion (Actual): June 1, 2015
• Study Completion (Actual): June 1, 2015

Study Registration Dates

• First Submitted: July 6, 2011
• First Submitted That Met QC Criteria: July 7, 2011
• First Posted (Estimated): July 8, 2011

Study Record Updates

• Last Update Posted (Actual): September 6, 2023
• Last Update Submitted That Met QC Criteria: August 30, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Keywords: hepatocellular carcinoma; liver disease
• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms by Histologic Type; Neoplasms; Neoplasms by Site; Adenocarcinoma; Neoplasms, Glandular and Epithelial; Digestive System Neoplasms; Liver Neoplasms; Liver Diseases; Carcinoma; Carcinoma, Hepatocellular
• Other Study ID Numbers: 0246-10-FB