High Plasma Level of Long Pentraxin 3 is Associated With Insulin Resistance in Women With Polycystic Ovary Syndrome (PCOS)

High Plasma Level of Long Pentraxin 3 is Associated With Insulin Resistance in Women With Polycystic Ovary Syndrome

In the present study, serum pentraxin 3 level and its relationship with insulin resistance were determined in patients with Polycystic Ovary Syndrome (PCOS. It was found that PTX3 level is increased in patients with PCOS and it is positively correlated with HOMA-IR.

Study Overview

• Status: Completed
• Conditions: PCOS

• Study Type: Observational
• Enrollment (Actual): 80

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey, 06018
    • Gulhane School of Medicine Dep. of Endocrine and Metabolism
  • Ankara, Turkey, 06018
    • Gulhane School of Medicine Dep. of Endocrinology and Metabolism
  • Ankara, Turkey, 06018
    • Gulhane School of Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

• Sampling Method: Probability Sample

Study Population

40 PCOS patients and 40 healty controls

Description

Inclusion Criteria:

• Absence of significant abnormalities on physical examination except hirsutism
• No lipid lowering, hypoglycemic, antihypertensive or hormone replacement therapy
• Normal thyroid function and prolactin level
• Absence of history or evidence of metabolic, cardiovascular, respiratory or hepatic disease

Exclusion Criteria:

• Pregnant
• Possible ovarian tumors,
• Congenital adrenal hyperplasia or
• BMI greater than 35 kg/m2

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Control group
PCOS patients

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Level of of pentraxin3 in cases with Polycystic Ovarian Syndrome	Mean PTX3 was significantly higher in patients with PCOS. This means that there is increased level of inflamation in patients with PCOS.	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Relationship of PTX3 with insuline resistance in patients with PCOS.	PTX3 was positively correlated with HOMA-IR. This means that inflamation may cause insuline resistance in patients with PCOS.	1 year

Collaborators and Investigators

• Sponsor: Gulhane School of Medicine
• Investigators: Principal Investigator: Aydogan Aydogdu, MD, Gulhane School of Medicine Dep. of Endocrinology and Metabolism

Study record dates

Study Major Dates

• Study Start: May 1, 2010
• Study Completion (Actual): May 1, 2011

Study Registration Dates

• First Submitted: October 23, 2011
• First Submitted That Met QC Criteria: November 1, 2011
• First Posted (Estimate): November 2, 2011

Study Record Updates

• Last Update Posted (Estimate): November 2, 2011
• Last Update Submitted That Met QC Criteria: November 1, 2011
• Last Verified: October 1, 2011

More Information

Terms related to this study

• Keywords: PCOS and PTX3 levels
• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Neoplasms; Endocrine System Diseases; Ovarian Cysts; Cysts; Ovarian Diseases; Adnexal Diseases; Gonadal Disorders; Hyperinsulinism; Polycystic Ovary Syndrome; Insulin Resistance
• Other Study ID Numbers: 23.10.2011; 24.05.2011 (Registry Identifier: pcos and PTX3)