Imaging the Dopamine Systems in Bulimia Nervosa

August 14, 2014 updated by: New York State Psychiatric Institute
This study will use positron emission tomography imaging to investigate the dopamine systems in people with bulimia nervosa.

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

33

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • New York
      • New York, New York, United States, 10032
        • New York State Psychiatric Institute

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 45 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Female

Sampling Method

Non-Probability Sample

Study Population

The study population will include people with bulimia nervosa seeking inpatient or outpatient treatment and people who will act as healthy control participants

Description

Inclusion Criteria:

Participants with BN:

  • Meets DSM-IV criteria for BN
  • Sufficiently medically and psychiatrically stable to participate in research

Health Control Participants:

  • No current or past psychiatric illness
  • Between 80% and 120% of ideal body weight

Exclusion Criteria:

All participants:

  • Current use of psychotropic medication such as anti psychotics or antidepressants
  • Pregnant or breastfeeding
  • history of substance abuse
  • Significant medical illness
  • High blood pressure (resting systolic blood pressure greater than 150mmHg and diastolic blood pressure greater that 90 mmHg)
  • Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder as defined by DSM-IV
  • Metal implants or paramagnetic objects contained within the body that may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to specified reference book guidelines
  • Exposed to radiation in the workplace or has had a nuclear medicine procedure during the 1 year before study entry
  • Previous adverse reaction to psycho stimulants

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
1
Participants with Bulimia Nervosa
2
Participants who are healthy controls

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
D2 receptor density
Time Frame: Measured at baseline
Measured at baseline
DA release in the striatum
Time Frame: Measures after Mythlyphenidate challenge
Measures after Mythlyphenidate challenge

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

New York State Psychiatric Institute

Collaborators

National Institute of Mental Health (NIMH)

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2008

Primary Completion (Actual)

December 1, 2013

Study Completion (Actual)

December 1, 2013

Study Registration Dates

First Submitted

December 14, 2011

First Submitted That Met QC Criteria

December 14, 2011

First Posted (Estimate)

December 16, 2011

Study Record Updates

Last Update Posted (Estimate)

August 15, 2014

Last Update Submitted That Met QC Criteria

August 14, 2014

Last Verified

November 1, 2011

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • #5175
  • R01MH079397 (U.S. NIH Grant/Contract)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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