Reducing Disabilities in Alzheimer's Disease (RDAD) Translation in Area Agencies on Aging (AAAs) (RDAD)

From Evidence-Base to Practice: Implementing RDAD in AAA Community-Based Services

The University of Washington's Northwest Research Group on Aging is partnering with Area Agencies on Aging (AAA) in Washington and Oregon to complete this translational investigation of RDAD (Reducing Disabilities in Alzheimer's Disease). RDAD is an evidence-based program with demonstrated efficacy in helping older adults with dementia maintain physical function and remain physically and mentally healthy. This study asks two questions: 1) Can AAA partners successfully translate and implement RDAD, and 2) Is AAA implementation of RDAD effective in producing desired outcomes among agencies, providers, and older adults with dementia and their family members. This study is being conducted in Washington and Oregon states.

Study Overview

• Status: Completed
• Conditions: Cognitive Impairment; Dementia; Alzheimer's Disease; Memory Impairment
• Intervention / Treatment: Behavioral: RDAD

• Study Type: Interventional
• Enrollment (Actual): 510
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Washington
    • Seattle, Washington, United States, 98195
      • University of Washington

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

Care Recipients must

• Have a diagnosis of dementia
• Be 65 years of age or older
• Currently exercise no more than 150 minutes a week and not regularly participate in a formal exercise program.

Caregivers must

• Live in the community
• Provide care to the care recipient with dementia

Exclusion Criteria:

Either Care-recipient or Caregiver must not

• Plan to move to a long-term residential care setting within 6 months of enrollment.
• Plan to move from the study geographic area within 4 months of enrollment.
• Have a known terminal illness (with death anticipated within the next 12 months)
• Have had a hospitalization for a psychiatric disorder in the 12 months prior to baseline
• Be actively suicidal, hallucinating, or delusional
• Be blind, deaf, or not ambulatory

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: RDAD; Exercise training for caregiver and care recipient. Behavior modification training for caregiver.	Behavioral: RDAD; Exercise training for caregiver and care recipient. Behavioral modification training for caregiver.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Minutes of exercise per week	Caregivers will track the number of minutes per week the care recipients engage in exercise recommended by the coach.	Change from baseline in number of minutes of exercise each week during treatment phase of study, weeks 7-12
Restricted Activity Days	Restricted Activity Days measures how much the participant cut down his/her usual activities in the previous two weeks because of injury or illness and how many days the participant stayed in bed in the previous two weeks because of injury or illness.	Baseline
Restricted Activity Days	Restricted Activity Days measures how much the participant cut down his/her usual activities in the previous two weeks because of injury or illness and how many days the participant stayed in bed in the previous two weeks because of injury or illness.	Change from Baseline to Pre-Treatment (6 weeks)
Restricted Activity Days	Restricted Activity Days measures how much the participant cut down his/her usual activities in the previous two weeks because of injury or illness and how many days the participant stayed in bed in the previous two weeks because of injury or illness.	Change from Baseline to Post- Treatment 1 (13 weeks)
Restricted Activity Days	Restricted Activity Days measures how much the participant cut down his/her usual activities in the previous two weeks because of injury or illness and how many days the participant stayed in bed in the previous two weeks because of injury or illness.	Change from Baseline to Post-Treatment 2 (30 weeks)
Restricted Days of Activity	Restricted Activity Days measures how much the participant cut down his/her usual activities in the previous two weeks because of injury or illness and how many days the participant stayed in bed in the previous two weeks because of injury or illness.	Change from Baseline to 13 Month Follow-Up
Independence/Residential Status	All participants will be in independent living situations at baseline. Any move from independent living to a care facility will be documented throughout the 13 month study.	Change from Baseline to 13 Month Follow-Up

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Revised Memory and Behavior Problem Checklist (RMBPC)	Checklist rates 24 care recipient behaviors for frequency of occurrence and caregiver reaction.	Baseline
Revised Memory and Behavior Problem Checklist (RMBPC)	Checklist rates 24 care recipient behaviors for frequency of occurrence and caregiver reaction.	Change from Baseline to Pre-Treatment (6 weeks)
Revised Memory and Behavior Problem Checklist (RMBPC)	Checklist rates 24 care recipient behaviors for frequency of occurrence and caregiver reaction.	Change from Baseline to Post-Treatment 1 (13 weeks)
Revised Memory and Behavior Problem Checklist (RMBPC)	Checklist rates 24 care recipient behaviors for frequency of occurrence and caregiver reaction.	Change from Baseline to Post-Treatment 2 (30 weeks)
Revised Memory and Behavior Problem Checklist (RMBPC)	Checklist rates 24 care recipient behaviors for frequency of occurrence and caregiver reaction.	Change from Baseline to 13 Month Follow-Up
Quality of Life-AD	This 13-item measure is specifically designed for individuals with dementia and focuses on quality of life domains identified as important for cognitively impaired older adults.	Baseline
Quality of Life-AD	This 13-item measure is specifically designed for individuals with dementia and focuses on quality of life domains identified as important for cognitively impaired older adults.	Change from Baseline to Pre-Treatment (6 weeks)
Quality of Life-AD	This 13-item measure is specifically designed for individuals with dementia and focuses on quality of life domains identified as important for cognitively impaired older adults.	Change from Baseline to Post-Treatment 1 (13 weeks)
Quality of Life-AD	This 13-item measure is specifically designed for individuals with dementia and focuses on quality of life domains identified as important for cognitively impaired older adults.	Change from Baseline to Post-Treatment 2 (30 weeks)
Quality of Life-AD	This 13-item measure is specifically designed for individuals with dementia and focuses on quality of life domains identified as important for cognitively impaired older adults.	Change from Baseline to 13 Month Follow-Up
CES-D	This 20-item scale that assesses depression in caregivers.	Baseline
CES-D	A 20-item scale that assesses depression in caregivers.	Change from Baseline to Pre-Treatment (6 weeks)
CES-D	A 20-item scale that assesses depression in caregivers.	Change from Baseline to Post-Treatment 1 (13 weeks)
CES-D	A 20-item scale that assesses depression in caregivers.	Change from Baseline to Post-Treatment 2 (30 weeks)
CES-D	A 20-item scale that assesses depression in caregivers.	Change from Baseline to 13 Month Follow-Up

Collaborators and Investigators

• Sponsor: University of Washington
• Investigators: Principal Investigator: Linda Teri, Ph.D., University of Washington

Publications and helpful links

General Publications

• Teri L, Logsdon RG, McCurry SM, Pike KC, McGough EL. Translating an Evidence-based Multicomponent Intervention for Older Adults With Dementia and Caregivers. Gerontologist. 2020 Apr 2;60(3):548-557. doi: 10.1093/geront/gny122.

Study record dates

Study Major Dates

• Study Start: November 1, 2012
• Primary Completion (Actual): June 1, 2017
• Study Completion (Actual): June 1, 2017

Study Registration Dates

• First Submitted: October 9, 2012
• First Submitted That Met QC Criteria: October 15, 2012
• First Posted (Estimate): October 16, 2012

Study Record Updates

• Last Update Posted (Actual): September 15, 2017
• Last Update Submitted That Met QC Criteria: September 14, 2017
• Last Verified: September 1, 2017

More Information

Terms related to this study

• Keywords: Exercise; Alzheimer's Disease; Dementia; Caregiver; Behavior modification
• Additional Relevant MeSH Terms: Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Neurodegenerative Diseases; Tauopathies; Dementia; Alzheimer Disease
• Other Study ID Numbers: 41906