EtCO2 Monitoring in Acute Self-poisoning (CAPNOTOX)

February 25, 2013 updated by: University Hospital, Grenoble

Continuous EtCO2 Monitoring in Acute Self Poisoned Patients Admitted in an Emergency Department

There is no consensus on monitoring criteria in acute self poisoning. Clinical scores, vital signs or lactatemia have failed to prove good predictive value.

The main acute self poisoning complication is decreased consciousness level with consequent increased risk of hypoxemia and aspiration pneumonitis.

Several clinical studies have recently shown that EtCO2 monitoring can be valuable in procedural sedation in the emergency department. It is able to predict hypoxemia before any SaO2 decrease and any complications related to these procedures.

We therefore hypothesized that EtCO2 could help in acute self poisoning patients' monitoring in the ED.

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

200

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Grenoble, France
        • Recruiting
        • Genoble university hospital
        • Contact:
        • Principal Investigator:
          • Maxime Maignan, MD, MSc

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

All patients over 18y/o admitted in the ED for acute self poisoning.

Description

Inclusion Criteria:

  • >18y/o
  • acute self poisoning patients
  • patients requiring monitoring according to physician's opinion
  • patients not requiring invasive ventilation at ED admission

Exclusion Criteria:

  • Pregnant woman
  • patients deprived of liberty

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Acute poisoning
Consecutive acute drug self poisoned patients admitted in the ED.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
ROC curve of maximal EtCO2 to predict poisoning complication
Time Frame: During the first 2 hours of ED admission

Poisoning complications are defined as:

Hypoxia (Spo2<93%) and/or Respiratory rate <10/min or >25/min and/or ICU admission and/or Oro tracheal intubation
During the first 2 hours of ED admission

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Grenoble

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2012

Primary Completion (Anticipated)

November 1, 2013

Study Registration Dates

First Submitted

February 25, 2013

First Submitted That Met QC Criteria

February 25, 2013

First Posted (Estimate)

February 27, 2013

Study Record Updates

Last Update Posted (Estimate)

February 27, 2013

Last Update Submitted That Met QC Criteria

February 25, 2013

Last Verified

February 1, 2013

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2011-14 (AP HM)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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