the Influence of Tidal Volume to Lung Strain

the Influence of Different Tidal Volume to Lung Strain of ARDS Patients

Measure the lung strain in different tidal volume in ADRS patients to find the relationship between tidal volume and lung strain and find the most suitable tidal volume for each patient.

Study Overview

• Status: Unknown
• Conditions: Acute Respiratory Distress Syndrome; Critically Ill

Detailed Description

Purpose:Find the relationship between tidal volume and lung strain in ARDS patients.Then find the most suitable tidal volume for each patient according to the dividing value.

Methods:Measure the lung strain in the tidal volume of 6mL/kg,8mL/kg,10mL/kg and 12mL/kg in each ARDS patient.

Hypothesis:With the increase of the tidal volume,the lung strain develops.In the patient with larger lung compliance,the strain of the group of conventional tidal volume is less than 0.27 and there is no obvious difference between the group of small tidal volume.

• Study Type: Observational
• Enrollment (Anticipated): 25

Contacts and Locations

Study Locations

• China
  • Jiangsu
    • Nanjing, Jiangsu, China, 210009
      • Recruiting
      • Affiliated Zhongda Hospital of Southeast University
      • Contact: Xiaohua Qiu, MD; Phone Number: 0086-025-83262553; Email: xiaohua0917@163.com
      • Sub-Investigator: Xiaohua Qiu, MD
      • Contact: Fang Jin, MD; Phone Number: 0086-15850601638; Email: doris_king@163.com
      • Principal Investigator: Fang Jin, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 85 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Critical patients diagnosed with acute respiratory distress syndrome

Description

Inclusion Criteria:

1. Age:18-85,gender is not limited
2. Needing Invasive ventilation
3. Fit the definition of ARDS in 2012 "Berlin Definition"
4. Sign the paper of informed consent

Exclusion Criteria:

1. pregnancy and at the end stage of tumour
2. the COPD patients
3. less than 24h of mechanical ventilation
4. more than 5 days of mechanical ventilation
5. FiO2>80%
6. presence of air leaks
7. organ dysfunction and hemodynamic instability
8. including in other research

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
the strain in different tidal volume	Use the GE ventilator to measure the EELV and calculate the lung strain(lung strain = VT/EELV)	2 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
28 days mortality	Follow up to determine the mortality in 28 days after inclusion	28 days

Collaborators and Investigators

• Sponsor: Zhongda Hospital

Publications and helpful links

General Publications

• Xie J, Jin F, Pan C, Liu S, Liu L, Xu J, Yang Y, Qiu H. The effects of low tidal ventilation on lung strain correlate with respiratory system compliance. Crit Care. 2017 Feb 3;21(1):23. doi: 10.1186/s13054-017-1600-x.

Study record dates

Study Major Dates

• Study Start: June 1, 2013
• Primary Completion (Anticipated): March 1, 2014
• Study Completion (Anticipated): March 1, 2014

Study Registration Dates

• First Submitted: May 21, 2013
• First Submitted That Met QC Criteria: May 28, 2013
• First Posted (Estimate): May 29, 2013

Study Record Updates

• Last Update Posted (Estimate): February 11, 2014
• Last Update Submitted That Met QC Criteria: February 8, 2014
• Last Verified: May 1, 2013

More Information

Terms related to this study

• Keywords: Acute respiratory distress syndrome; lung strain; small tidal volume
• Additional Relevant MeSH Terms: Pathologic Processes; Respiratory Tract Diseases; Respiration Disorders; Lung Diseases; Disease Attributes; Infant, Newborn, Diseases; Lung Injury; Infant, Premature, Diseases; Critical Illness; Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn; Acute Lung Injury
• Other Study ID Numbers: 20130519