- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01919957
Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies (MemO-Epi)
Etude de la mémoire Avant et après Chirurgie d'Une épilepsie Partielle pharmacorésistante : Bases Neurobiologiques, Applications Cliniques
This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies.
Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.
Study Overview
Status
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Sophie Dupont, MD, PhD
- Phone Number: +33 01 42 17 85 23
- Email: sophie.dupont@psl.aphp.fr
Study Contact Backup
- Name: Virginie Lambrecq, MD
- Email: vlambrecq@hotmail.fr
Study Locations
-
-
Cedex 13
-
Paris, Cedex 13, France, 75651
- Recruiting
- INSERM - Plateau IRM du CENIR, CR-ICM Hôpital Pitié-Salpêtrière, 47/83 Boulevard de l'Hôpital
-
Sub-Investigator:
- Stéphane Lehéricy, MD, PhD
-
Contact:
- Sophie Dupont, MD, PhD
- Phone Number: +33 01 42 17 85 23
- Email: sophie.dupont@psl.aphp.fr
-
Contact:
- Virginie Lambrecq, MD
- Email: vlambrecq@hotmail.fr
-
Principal Investigator:
- Sophie Dupont, MD, PhD
-
Sub-Investigator:
- Virginie Lambrecq, MD
-
Sub-Investigator:
- Véra Dinkelacker, MD
-
Sub-Investigator:
- Lionel Thivard, MD, PhD
-
Sub-Investigator:
- Claude Adam, MD, PhD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients with drug-resistant epilepsy
- Age of 18 years or more
- Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
- Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
- Covered by a social security system
- Signing of consent form
Exclusion Criteria:
- Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
- Refusal to consent form
- Contraindications to MRI
- Pregnancy
- Refusal to be informed in the case of detection of an abnormality during the experiment
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
No Intervention: memory outcome
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Measure of successfull encoding
Time Frame: 8 years
|
Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI
|
8 years
|
Collaborators and Investigators
Investigators
- Principal Investigator: Sophie Dupont, MD, PhD, Service de Soins de Suites et Réadaptation Neurologique, Hôpital de la Pitié-Salpêtrière, 47/83 Bd de l'Hôpital, 75651 Paris Cedex 13
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- C12-11
- 2013-A00343-42 (Registry Identifier: C12-11)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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