Bending Adolescent Depression Trajectories Through Personalized Prevention

Investigators will combine risk factor research and evidence-based prevention programs, to advance knowledge on personalized approaches to prevention that may be able to better "bend trajectories" of depression that surge throughout adolescence.

Study Overview

• Status: Completed
• Conditions: Depression
• Intervention / Treatment: Behavioral: Interpersonal Psychotherapy- Adolescent Skills Training; Behavioral: Coping with Stress

Detailed Description

Investigators will innovatively combine risk factor research and evidence-based prevention programs, to advance knowledge on personalized approaches to prevention that may be able to better "bend trajectories" of depression that surge throughout adolescence. A randomized controlled trial will examine the benefits of matching youth to two depression prevention programs of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST) and Coping with Stress (CWS) for the prevention of depression in adolescents. These two programs are designed to address distinct risk factors for depression - CWS addresses cognitive risks and IPT-AST addresses interpersonal risks. A total of 210 participants across two sites, University of Denver and Rutgers University, will be stratified on cognitive and interpersonal risk and randomized to the two conditions. The goals of the study are to (1) demonstrate that prevention programs can modify depression trajectories among youth by examining within person changes in trajectories over time (three years before and three years after the prevention programs) and by comparing trajectories of prevention youth with changes in same aged cohorts; (2) evaluate a personalized prevention approach to bending depression trajectories by matching and mismatching youth to either CWS or IPT-AST based on individual risk profiles; (3) examine mechanisms of bending depression trajectories and test whether the prevention programs operate via their hypothesized processes; and (4) explore how genetic susceptibility, emotion regulation, and temperament may affect individual response to IPT-AST and CWS. By implementing evidence-based prevention programs after 3-years of prospective naturalistic data collection, this study will contribute essential data on personalized medicine and altering developmental trajectories of first-onset depression.

• Study Type: Interventional
• Enrollment (Actual): 205
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Colorado
    • Denver, Colorado, United States, 80208
      • University of Denver
  • Illinois
    • Champaign, Illinois, United States, 61820
      • University of Illinois Urbana Champaign
  • New Jersey
    • Piscataway, New Jersey, United States, 08854
      • Rutgers University
  • Pennsylvania
    • Philadelphia, Pennsylvania, United States, 19146
      • Children's Hospital of Philadelphia

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 12 years to 17 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Currently in the 6th to 11th grades
• Adolescent and parent must be English-speaking
• Parental consent and adolescent consent

Exclusion Criteria:

• Presence of current Major Depressive Disorder, dysthymia, bipolar disorder, or significant psychosis
• Suicide attempt in the past week or significant suicidal ideation in the past week
• Presence of significant psychopathology or significant pervasive developmental delays that would make the group inappropriate

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Interpersonal Psychotherapy- Adolescent Skills Training	Behavioral: Interpersonal Psychotherapy- Adolescent Skills Training; A group prevention program that includes a 60-minute pre-group session, 8 weekly 90-minute group sessions, a 60-minute mid-group session, and 3 60-minute booster sessions. IPT-AST focuses on psychoeducation and interpersonal skill-building to decrease interpersonal conflict and increase interpersonal support and competence.; Other Names: IPT-AST; Teen Talk
Experimental: Coping with Stress	Behavioral: Coping with Stress; A group prevention program that consists of 8 acute 90-minute group sessions, 2 parent group sessions, and 3 continuation sessions lasting 60 minutes each. Participants are taught to apply cognitive techniques to their personal thoughts, with the goal of generating effective counterarguments to unrealistic negative beliefs.; Other Names: CWS

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Presence of a Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL)	Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation.	Post intervention (approximately 3 months post baseline)
Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL)	Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation.	6-months post-intervention
Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL)	Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation.	12-months post-intervention
Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL)	Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation.	18-months post-intervention
Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL)	Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation.	24-months post-intervention
Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL)	Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation.	30-months post-intervention
Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL)	Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation.	36-months post-intervention
Children's Depression Inventory (CDI)	Self-reported depression scores	Post intervention (approximately 3 months after baseline)
Children's Depression Inventory (CDI)	Self-reported depression scores	6-months post-intervention
Children's Depression Inventory (CDI)	Self-reported depression scores	12-months post-intervention
Children's Depression Inventory (CDI)	Self-reported depression scores	18-months post-intervention
Children's Depression Inventory (CDI)	Self-reported depression scores	24-months post-intervention
Children's Depression Inventory (CDI)	Self-reported depression scores	30-months post-intervention
Children's Depression Inventory (CDI)	Self-reported depression scores	36-months post-intervention

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Children's Global Assessment Scale (CGAS)	Assesses global functioning	Post Intervention (approximately 3 months following baseline)
Children's Global Assessment Scale (CGAS)	Assesses global functioning	6-months followup
Children's Global Assessment Scale (CGAS)	Assesses global functioning	12-months followup
Children's Global Assessment Scale (CGAS)	Assesses global functioning	18-months followup
Children's Global Assessment Scale (CGAS)	Assesses global functioning	24-months followup
Children's Global Assessment Scale (CGAS)	Assesses global functioning	30-months followup
Children's Global Assessment Scale (CGAS)	Assesses global functioning	36-months followup

Collaborators and Investigators

• Sponsor: Children's Hospital of Philadelphia
• Collaborators: National Institute of Mental Health (NIMH); University of Illinois at Urbana-Champaign; Rutgers University; University of Denver
• Investigators: Principal Investigator: Jami F Young, Ph.D., Children's Hospital of Philadelphia

Publications and helpful links

General Publications

• Young JF, Jones JD, Gallop R, Benas JS, Schueler CM, Garber J, Hankin BL. Personalized Depression Prevention: A Randomized Controlled Trial to Optimize Effects Through Risk-Informed Personalization. J Am Acad Child Adolesc Psychiatry. 2021 Sep;60(9):1116-1126.e1. doi: 10.1016/j.jaac.2020.11.004. Epub 2020 Nov 13.

Study record dates

Study Major Dates

• Study Start: September 1, 2013
• Primary Completion (Actual): August 1, 2019
• Study Completion (Actual): August 1, 2019

Study Registration Dates

• First Submitted: September 18, 2013
• First Submitted That Met QC Criteria: September 18, 2013
• First Posted (Estimate): September 23, 2013

Study Record Updates

• Last Update Posted (Actual): March 4, 2021
• Last Update Submitted That Met QC Criteria: March 2, 2021
• Last Verified: March 1, 2021

More Information

Terms related to this study

• Keywords: Adolescents; Depression; Prevention
• Additional Relevant MeSH Terms: Behavioral Symptoms; Mental Disorders; Mood Disorders; Depression; Depressive Disorder
• Other Study ID Numbers: 17-013831; R01MH077178 (U.S. NIH Grant/Contract)