- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02003781
Individualized Prevention Strategy for High Risk Patients in Cardiovascular Disease: Prospective Cohort Study (Cardiovascular and Metabolic Disease Etiology Research Center - HIgh Risk Cohort) CMERC-HI
July 15, 2018 updated by: Yonsei University
Set the prospective cohort (CMERC-HI) to study the known and novel etiologies and related factors for predicting clinical outcomes in Korean patients with high risk cardiovascular disease.
Study Overview
Status
Recruiting
Conditions
Study Type
Observational
Enrollment (Anticipated)
4000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Sungha Park, MD
- Phone Number: 82-2-2228-8455
- Email: shpark0530@yuhs.ac
Study Locations
-
-
-
Seoul, Korea, Republic of, 120-752
- Recruiting
- Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine
-
Contact:
- Sungha Park, MD
- Phone Number: 82-2-2228-8455
- Email: shpark0530@yuhs.ac
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
high risk cardiovascular disease patients and their relatives
Description
Inclusion Criteria:
- high risk hypertension patients a. eGFR > 60 with one of target organ damages b. eGFR <= 60
- diabetes mellitus with microalbumin ration (AC ratio >= 30mg/g)
- anuric ESRD patients on dialysis
- the relatives of acute myocardial infarction patients under 55 years old (men)/ 65 years old (women)
- atherosclerotic cardiovascular disease (abdominal aorta diameter ≥3 cm or ankle-brachial index <0.9, or carotid plaque or carotid intima-media thickness ≥0.9 mm, or asymptomatic old cerebrovascular accident, or >30% stenosis in at least one major coronary artery)
- rheumatoid arthritis patients aged > 40 years on MTX and steroid therapy
- atrial fibrillation patients with CHADS-VASc Score ≥ 1
- kidney transplant recipient at > 3 months after transplantation
Exclusion Criteria:
- acute myocardial infarction, acute coronary syndrome patients, symptomatic coronary artery disease or history of these diseases
- symptomatic peripheral artery disease, heart failure and history of these diseases
- desired life time under 6 months due to non-cardiovascular disease (e.g. cancer, sepsis)
- women with pregnancy or on nursing
- history of contrast allergy and related side effects
- within the first three months after transplantation
- acute renal allograft rejection
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
cardiovascular disease
high risk cardiovascular disease patients and their relatives
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Prognosis of high risk cardiovascular disease
Time Frame: 10 year after recruting
|
all-cause mortality, cardiovascular mortality, non-cardiovascular mortality new onset of acute myocardial infarction, acute coronary syndrome, heart failure, stroke, peripheral artery disease, hospitalization for revascularization and these disease |
10 year after recruting
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Seo J, Lee CJ, Oh J, Lee SH, Kang SM, Park S. Large discrepancy between unobserved automated office blood pressure and ambulatory blood pressure in a high cardiovascular risk cohort. J Hypertens. 2019 Jan;37(1):42-49. doi: 10.1097/HJH.0000000000001868.
- Park S, Lee CJ, Jhee JH, Yun HR, Kim H, Jung SY, Kee YK, Yoon CY, Park JT, Kim HC, Han SH, Kang SW, Park S, Yoo TH. Extracellular Fluid Excess Is Significantly Associated With Coronary Artery Calcification in Patients With Chronic Kidney Disease. J Am Heart Assoc. 2018 Jun 30;7(13):e008935. doi: 10.1161/JAHA.118.008935.
- Joo WT, Lee CJ, Oh J, Kim IC, Lee SH, Kang SM, Kim HC, Park S, Youm Y. The Association between Social Network Betweenness and Coronary Calcium: A Baseline Study of Patients with a High Risk of Cardiovascular Disease. J Atheroscler Thromb. 2018 Feb 1;25(2):131-141. doi: 10.5551/jat.40469. Epub 2017 Jul 21.
- Oh J, Lee CJ, Kim IC, Lee SH, Kang SM, Choi D, Park S, Kario K. Association of Morning Hypertension Subtype With Vascular Target Organ Damage and Central Hemodynamics. J Am Heart Assoc. 2017 Feb 14;6(2):e005424. doi: 10.1161/JAHA.116.005424.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2013
Primary Completion (Anticipated)
October 1, 2023
Study Completion (Anticipated)
October 1, 2023
Study Registration Dates
First Submitted
December 2, 2013
First Submitted That Met QC Criteria
December 2, 2013
First Posted (Estimate)
December 6, 2013
Study Record Updates
Last Update Posted (Actual)
July 17, 2018
Last Update Submitted That Met QC Criteria
July 15, 2018
Last Verified
July 1, 2018
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 4-2013-0581
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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