Muscle Blood Flow During Exercise

March 4, 2021 updated by: University Hospital, Strasbourg, France

Muscle Blood Flow Control During Exercise in Humans: Contribution From Mechanical and Metabolic Signals and Role of the Erythrocyte.

Physical exercise triggers various physiological responses including a marked increase in muscle blood flow and oxygen delivery in order to support muscle activity. How muscle blood flow is controlled is currently unclear.

The primary purpose of this study is to establish the respective contribution of metabolic (linked to energy requirements) and mechanical (linked to muscle tensions) signals in the exercise hyperemia and the possible role of the red blood cells.

Vasodilation and muscle blood flow during exercise are controlled by ATP released in the plasma from the red blood cells in response to a combination of metabolic and mechanical signals applied on the vasculature.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

20

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Strasbourg, France, 67091
        • SERVICE DE PHYSIOLOGIE ET D'EXPLORATIONS FONCTIONNELLES - Nouvel Hôpital Civil

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 45 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Sampling Method

Non-Probability Sample

Study Population

Subjects will be students recruited in the Faculty, sports clubs...

Description

Inclusion Criteria:

  • Non smoker or having stopped smoking for at least 5 yr
  • Practice sports: physical activity level will be evaluated with a questionnaire (de Baecke et coll., 1982) and will give an activity index greater than 6 together with a VO2max greater than 50 ml/kg/min
  • Body mass index lower than 25
  • Registered to the French Social Security system
  • Providing a written and informed consent to participate in the study

Exclusion Criteria:

  • History of venous or arterial thrombo-embolic events
  • Bad perfusion from the cubital artery
  • Unable to understand the information notice
  • Subject exposed to law investigations or with financial dependancy
  • Subjects feeling unwell whan seing blood.
  • Subjects advised to not practice sport.
  • Musculo-tendinous or articular issues with the lower leg
  • Respiratory, cardiovascular or metabolic pathologies
  • Current medical treatment that can not be stopped 7 days before the experiment.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Concentric vs eccentric
One arm study in which each subject will act as his own control.
Other: Session 1-4
Familiarization sessions to knee-extensor exercise separated by 72h recovery
Other: Session 4
After the last familiarization session, 1 maximal incremental test on a bicycle, followed by 72h rest
Other: Session 5
2 maximal incremental tests of knee-extension exercise (concentric vs eccentric), separated by 3h rest.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in leg blood flow during concentric and eccentric muscle work
Time Frame: Leg blood flow measurements during exercises performed at the beginning, after 14 minutes, then after 18 min, 22 min, 26 min, 30 min, 33 min, 35 min and 45 min
Serial measures (9) of leg blood flow during concentric and eccentric muscle work are performed at the beginning of the exercise (t0), and then after 14 minutes (t14), after 18 minutes (t18), after 22 minutes (t22), after 26 minutes (t26), after 30 minutes (t30), after 33 minutes (t33), after 35 minutes (t35), and after 45 minutes (45) during each exercice, concentric and eccentric.
Leg blood flow measurements during exercises performed at the beginning, after 14 minutes, then after 18 min, 22 min, 26 min, 30 min, 33 min, 35 min and 45 min

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Strasbourg, France

Investigators

  • Principal Investigator: Stéphane DOUTRELEAU, MD, Hôpitaux Universitaires de Strasbourg
  • Study Director: DUFOUR Stéphane, MD, Faculté des Sciences du Sport 14 Rue René Descartes 67084 Strasbourg
  • Study Chair: FAVRET Fabrice, MD, Faculté des Sciences du Sport 14 Rue René Descartes 67084 Strasbourg
  • Principal Investigator: LONSDORFER Evelyne, MD, Hôpitaux Universitaires de Strasbourg

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 1, 2018

Primary Completion (Actual)

October 19, 2018

Study Completion (Actual)

October 19, 2018

Study Registration Dates

First Submitted

February 14, 2014

First Submitted That Met QC Criteria

February 24, 2014

First Posted (Estimate)

February 25, 2014

Study Record Updates

Last Update Posted (Actual)

March 5, 2021

Last Update Submitted That Met QC Criteria

March 4, 2021

Last Verified

March 1, 2021

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 5456

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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