Consolidation & Interference in Multiple Sclerosis

July 28, 2016 updated by: Joshua Sandry, Kessler Foundation
The purpose of this research study is to investigate whether minimizing interference improves memory in multiple sclerosis.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The ability to form new long-lasting memories is important for successful independent living and a high quality of life. Roughly half of the individuals diagnosed with Multiple Sclerosis (MS) have difficulty remembering new information and this is likely associated with poor acquisition of new information. There are only a limited number of studies that have investigated memory consolidation in MS. The current study will investigate the role of interference during the consolidation time period of memory formation.

Study Type

Interventional

Enrollment (Actual)

39

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • New Jersey
      • West Orange, New Jersey, United States, 07052
        • Kessler Foundation

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • If you are between the ages of 18-65.
  • If you have a diagnosis of Multiple Sclerosis (MS) or are medically healthy.
  • If you have MS, you have not had a flare up of MS symptoms in the past month.
  • You do not have other neurological issues such as, Epilepsy or Stroke.
  • You do not have a significant history of psychiatric problems or a current diagnosis of Major Depressive Disorder, Schizophrenia, Bipolar Disorder .
  • You do not have a significant history of drug or alcohol abuse.
  • You can read and speak English fluently.
  • You are not currently taking steroids.

Exclusion Criteria:

  • You are younger than 18 years old.
  • You are older than 65 years old.
  • You have had a prior stroke or neurological disease other than MS.
  • You have a history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder, Bipolar Disorder.
  • You have a significant alcohol or drug abuse history.
  • You are currently taking steroids.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Unfilled interference
Interference onset: delayed test at 540000 ms
Behavioral: Interference onset
Temporal duration of interference onset.
Experimental: Early interference
Interference onset: delayed test at 0 ms
Behavioral: Interference onset
Temporal duration of interference onset.
Experimental: Mid interference
Interference onset: delayed test at 360000 ms
Behavioral: Interference onset
Temporal duration of interference onset.
Experimental: Late interference
Interference onset: delayed test at 180000 ms
Behavioral: Interference onset
Temporal duration of interference onset.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Recall Proportion
Time Frame: 2 hours
2 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Kessler Foundation

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2014

Primary Completion (Actual)

May 1, 2015

Study Completion (Actual)

May 1, 2015

Study Registration Dates

First Submitted

March 5, 2014

First Submitted That Met QC Criteria

March 5, 2014

First Posted (Estimate)

March 7, 2014

Study Record Updates

Last Update Posted (Estimate)

August 1, 2016

Last Update Submitted That Met QC Criteria

July 28, 2016

Last Verified

July 1, 2016

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • R-800-13

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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