A Cross-sectional Study of Young-onset Diabetes in Two UK Ethnic Groups.

MODY in Young-onset Diabetes in Different Ethnicities

Sponsors

Lead sponsor: Imperial College London

Source Imperial College London
Brief Summary

The purpose of this study is to describe and compare the different types of diabetes that exist in people from white European and south Asian origin in the UK (United Kingdom) who are diagnosed with diabetes before they turn 30 years old. By doing this we hope to identify cases of MODY (maturity onset diabetes of the young), which is a rare genetic cause of diabetes that is frequently misdiagnosed. Identifying MODY cases is important, as the treatment may differ to conventional treatment for type 1 or type 2 diabetes.

Detailed Description

People who meet the recruitment criteria, will be invited to attend for a single fasted 2 hour visit at our research facility. During the visit we will record details of their diabetes history as well as their general health and undertake blood and urine tests. At the end of the visit their participation will be complete. We will contact them later to discuss results of specialist blood tests and whether or not they have MODY, if they have had genetic testing performed.

Overall Status Recruiting
Start Date October 2013
Completion Date June 2021
Primary Completion Date June 2021
Study Type Observational
Primary Outcome
Measure Time Frame
Frequency of MODY 5 years
Secondary Outcome
Measure Time Frame
Comparison of biochemical and clinical characteristics in people with MODY between each ethnic group. 5 years
Comparison of clinical and biochemical characteristics of other subtypes of diabetes 5 years
Enrollment 916
Condition
Eligibility

Sampling method: Probability Sample

Criteria:

Inclusion Criteria:

- Diagnosed with diabetes on the basis of fasting glucose and/or oral glucose tolerance test and/or HbA1c as per WHO criteria.

- Diagnosed with diabetes between 6 months and 30 years of age.

- South Asian ancestry- defined as self-reported ancestry and at least 2 grandparents from the Indian Subcontinent (India, Pakistan, Bangladesh or Sri Lanka).

- European ancestry - defined as self-reported ancestry and at least 2 grandparents from within Europe.

Exclusion Criteria:

- An established secondary cause of diabetes exists (for example recurrent pancreatitis, pancreatectomy, new onset diabetes after transplantation, Cushing's syndrome, acromegaly, steroid induced).

- Enrolled in another study.

- Have active malignancy or under investigation for malignancy.

Gender: All

Minimum age: 6 Months

Maximum age: N/A

Healthy volunteers: No

Overall Official
Overall Contact

Last name: Nick S Oliver, MRCP

Phone: +442033311065

Email: [email protected]

Location
facility status contact investigator Imperial College Clinical Research Facility Shivani Misra, MBBS, MRCP 0207 594 2460 [email protected] Shivani Misra, MBBS, MRCP Principal Investigator
Location Countries

United Kingdom

Verification Date

June 2019

Responsible Party

Responsible party type: Sponsor

Has Expanded Access No
Condition Browse
Acronym MYDIABETES
Patient Data No
Study Design Info

Observational model: Other

Time perspective: Cross-Sectional

Source: ClinicalTrials.gov