Exercise and Neural Response to Food Cues in Children

Effect of Exercise on the Neural Response to Food Cues and Energy Intake in Lean and Obese Adolescents

Physical exercise has been shown to significantly reduce subsequent energy intake in obese adolescents but not in lean, without altering their appetite feelings. Although previous studies have pointed out the role of gastric peptides in this post exercise nutritional response, some recent work question the role of the neural system in the post exercise drive to eat. This study tends to explore whether or not an acute bout of exercise can affect the neural response to food cues in adolescents, obese or lean.

Study Overview

• Status: Withdrawn
• Conditions: Exercise Condition (EX); Control Session (CON)

Detailed Description

After a medical inclusion, the adolescents will have to realise a DXA to assess their body composition and a submaximal exercise to evaluate their aerobic capacities.

They will have then to enter the laboratory on 2 different occasions in a randomized order from 8am to 330pm: At 8am they will receive a calibrated breakfast. then, at 1045; they will have to complete one of the experimental condition: 1) a cycling exercise or 2) remaining sitting fpr one hour. after the one hour sitting station or the exercise bout, they will be asked to complete a computer task while and electroencephalogram will be recorded. This computer task consists in visual recognition of rare pictures compared to frequent ones (oddball method). at 1215 they will be offered ad libitum meals. At regular intervals through the day, their appetite feelings will be assessed using Visual analogue scales.

Ad libitum energy consumption will be assessed by investigators and recorded for each participants.

• Study Type: Observational

Contacts and Locations

Study Locations

• France
  • Aubiere, France, 63170
    • Laboratory AME2P

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 12 years to 15 years (Child)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

• Sampling Method: Probability Sample

Study Population

Lean and obese adolescents will be recruited accodring to the international curves for obesity. they will be between 12 to 15 years old and will have no medical limitations to complete exercise testings.

Description

Inclusion Criteria:

• male
• 12-15 years old
• BMI defining obesity (Cole et al., 2000)
• Not being under diet restriction
• Information and consent forms have to be signed by the adolescent and his legal representative
• being registered to the national social security system

Exclusion Criteria:

• Being under medication
• contraindication to exercise
• smokers
• dieting

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Lean adolescents
Obese adolescents

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Neural response to food cues	The electroencephalogram signals amplitude in response to visual food cues will be the primary outcome, after the exercise (during the exercise condition) and after the sitting position (during the control session)	up to 2 months

Collaborators and Investigators

• Sponsor: Université Blaise Pascal, Clermont-Ferrand

Study record dates

Study Major Dates

• Study Start: March 1, 2014
• Primary Completion (Actual): March 1, 2014
• Study Completion (Anticipated): March 1, 2015

Study Registration Dates

• First Submitted: March 27, 2014
• First Submitted That Met QC Criteria: March 27, 2014
• First Posted (Estimate): April 1, 2014

Study Record Updates

• Last Update Posted (Estimate): April 2, 2014
• Last Update Submitted That Met QC Criteria: April 1, 2014
• Last Verified: April 1, 2014

More Information

Terms related to this study

• Other Study ID Numbers: AU1107