Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics (VAX-002)

July 17, 2018 updated by: Nadine Rouphael, Emory University

Systems Biology of Inactivated Influenza Vaccine (IIV) in Healthy Adults With or Without Use of Broad Spectrum Antibiotics

The purpose of the study is to better understand how the use of antibiotics changes micro-organisms in the intestines. The change to micro-organisms in the intestines may change the body's vaccine immune response and alter the effectiveness of the IIV (seasonal flu) vaccine.

In particular, the investigators will be looking at certain markers in blood after vaccination with IIV (seasonal flu vaccine) with or without the use of antibiotics before vaccination.

There will be two randomized groups. Group A will start taking antibiotic by mouth 3 days prior to vaccination and continue taking antibiotics the day of vaccination and one day after vaccination for a total of 5 days. Group B will only receive the IIV (seasonal flu vaccine) and will not take any antibiotics.

The investigators hope to enroll 50 subjects at Emory.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

We will study using a system biology approach the immune responses to IIV alone vs. IIV with antibiotic administration

Study Type

Interventional

Enrollment (Actual)

33

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Georgia
      • Atlanta, Georgia, United States, 30030
        • Emory Vaccine Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  1. Healthy individuals aged 18-40 years.
  2. Able to understand and give informed consent.
  3. Women of child-bearing potential (not surgically sterile via tubal ligation, bilateral oophorectomy or hysterectomy or who are not postmenopausal for ≥1 year) must agree to practice adequate contraception that may include, but is not limited to, abstinence, monogamous relationship with vasectomized partner, barrier methods such as condoms, diaphragms, spermicides, intrauterine devices, and licensed hormonal methods for 30 days before and 30 days after TIV vaccination

Exclusion Criteria:

  • You received blood product within 3 months of enrolling in the study or a live attenuated vaccine within 4 weeks or inactivated vaccines within 2 weeks.
  • You received the 2014-2015 flu vaccine or had a confirmed case of influenza during 2014-2015.
  • You received any antibiotics 6 months prior to enrolling in the study or expect to take antibiotics one month after vaccination.
  • You received probiotics or prebiotics 3 months prior before enrolling in the study or expect to take one month after vaccination.
  • You received proton pump inhibitors, H2 blocker receptors, or antacids 3 months regularly before enrolling in the study or one month after
  • You had an allergic response or sensitivity to past vaccinations.
  • You have health conditions that weaken your body's ability to fight infections or you are taking drugs like steroids that weaken your body's ability to fight infections.(Some nasal and topical steroids are allowed.).
  • You have a chronic medical problem including (but not limited to) insulin dependent diabetes, severe heart disease including arrhythmias, severe lung disease, auto immune diseases and or grade 4 uncontrolled hypertension.
  • Chronic neurological conditions such as seizure disorder, Parkinson disease, myasthenia gravis, neuropathy, or histories of encephalopathy, meningitis or ototoxicity.
  • Any history of gastrointestinal disease, kidney or liver diseases.
  • Alcohol or drug abuse or psychiatric conditions that in the opinion of the investigator would compromise your participation in this trial.
  • Pregnant or are breast feeding.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: IIV Flu Vaccine with Antibiotics
This arm will receive antibiotics prior and after IIV administration.
Drug: IIV Flu Vaccine
This is an FDA approved and tested Inactivated Flu Vaccine.
Other Names:
  • Fluzone
Drug: Metronidazole
This is a standard antibiotic
Other Names:
  • Flagyl
Drug: Neomycin
This is a standard antibiotic.
Drug: Vancomycin
This is a standard antibiotic.
Other Names:
  • Vancocin
Active Comparator: IIV Flu Vaccine
This arm will not take antibiotics in conjunction with IIV.
Drug: IIV Flu Vaccine
This is an FDA approved and tested Inactivated Flu Vaccine.
Other Names:
  • Fluzone

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of Participants With Four Fold Rise in HAI Titers or HAI 1:40 and Above in Each Group at D30
Time Frame: At day 30
Number of participants with four fold rise in HAI titers or HAI 1:40 and above in each group at D30 will be recorded based on immunologic testing of blood samples
At day 30

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Emory University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

April 1, 2015

Primary Completion (Actual)

May 26, 2017

Study Completion (Actual)

May 26, 2017

Study Registration Dates

First Submitted

May 29, 2014

First Submitted That Met QC Criteria

May 30, 2014

First Posted (Estimate)

June 3, 2014

Study Record Updates

Last Update Posted (Actual)

August 15, 2018

Last Update Submitted That Met QC Criteria

July 17, 2018

Last Verified

July 1, 2018

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • IRB00074239

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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