Altered Vestibular Perception and Transcranial Magnetic Stimulation

Altered Vestibular Perception by Virtual Lesions of Cerebral and Cerebellar Structures Using Repetitive Transcranial Magnetic Stimulation - Implications for Human Vestibular Dysfunction

The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences motion sensation. Patients with vestibular disorders frequently have disabling disturbances of perception. Related to these symptoms is that large areas of the cerebral hemispheres and the cerebellum receive information from the vestibular, visual and somatosensory systems that is integrated within a vestibular cortical network into an accurate perception of spatial orientation. Interrupting the pathways that process information about the direction of gravity and angular velocity leads to impairment of the internal estimate of gravity and the perception of body motion. The strategy of this research is to use repetitive transcranial magnetic stimulation (rTMS) to produce transient focal lesions that allow study of acute loss of function within the central vestibular pathways at the very beginning of adaptation. Our underlying hypothesis is that the immediate effects of a lesion in the cerebellum will be to affect ocular motor control of vestibular reflexes and perception alike but with a cortical lesion there will be dissociation between ocular motor control and perception. This research helps to understand the mechanisms involved in the perception of vestibular information and the cerebellar influence on processing vestibular input and offers a unique opportunity to make major inroads into the understanding and eventually treatment of the often incapacitating symptoms of patients with vestibular disease

Study Overview

• Status: Terminated
• Conditions: Verticality Perception; Self-motion Perception
• Intervention / Treatment: Other: transcranial magnetic stimulation and motion stimuli

• Study Type: Interventional
• Enrollment (Actual): 7
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Switzerland
  • ZH
    • Zurich, ZH, Switzerland, 8091
      • University Hospital Zurich, Division of Neurology

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 70 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1. ages 18-70
2. informed consent

Exclusion Criteria:

1. disturbed consciousness
2. other neurological or systemic disorder which can cause dementia or cognitive dysfunction
3. prior history of a major psychiatric disorder
4. history of definite stroke
5. focal lesion on MRI exam
6. use of anxiolytic, antidepressant, neuroleptic or sedative medication
7. has MRI contraindication such as pacemaker, implanted pumps, shrapnel, etc. (full MRI screening form will be filled out).
8. History of seizure or a family history of epilepsy;
9. increased intracranial pressure, such as after infarctions or trauma
10. pregnancy or possibility of being pregnant unless precluded by a negative pregnancy test
11. history of any significant head trauma.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: TMS	Other: transcranial magnetic stimulation and motion stimuli

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
changes in verticality perception and self-motion perception after TMS (transcranial magnetic stimulation)	within 30min after TMS

Secondary Outcome Measures

Outcome Measure	Time Frame
vestibulo-ocular reflex after TMS (transcranial magnetic stimulation)	within 30min after TMS

Collaborators and Investigators

• Sponsor: University of Zurich
• Investigators: Principal Investigator: Dominik Straumann, Prof MD, University Hospital Zurich, Division of Neurology

Study record dates

Study Major Dates

• Study Start: October 1, 2011
• Primary Completion (Actual): November 1, 2016
• Study Completion (Actual): September 1, 2017

Study Registration Dates

• First Submitted: July 2, 2014
• First Submitted That Met QC Criteria: July 2, 2014
• First Posted (Estimate): July 9, 2014

Study Record Updates

• Last Update Posted (Actual): July 2, 2018
• Last Update Submitted That Met QC Criteria: June 28, 2018
• Last Verified: June 1, 2018

More Information

Terms related to this study

• Other Study ID Numbers: tms_percept_zurich