Gait, cOgnitiOn & Decline (GOOD)

January 28, 2015 updated by: University Hospital, Angers
The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

Gait disorders are frequent in individuals with cognitive disorders. However, the profile of spatio-temporal gait parameters in the different cognitive status in aging (from normal cognition to dementia) has been poorly studied. Determining this profile associated with the severity of cognitive disorders may be helpful to understand the complex interplay between gait and cognitive disorders and, thus, may have important implication for the diagnosis process of patients with and without dementia. For instance, defining a motor phenotype of the severity of cognitive disorders by using quantitative gait measurements could be used to improve the prediction and the diagnosis of dementia.

The investigators hypothesized that, compared to CHI, people with MCI and mild dementia could be characterized by specific phenotypes of spatio-temporal gait parameters measured with the GAITRite® system, and that these profiles could be explained by declines in domain-specific cognitive performance.

Study Type

Observational

Enrollment (Anticipated)

2800

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Angers, France, 49933
        • Recruiting
        • University Hospital
        • Contact:
        • Principal Investigator:
          • Olivier Beauchet, MD, PhD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

60 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients were recruited in each memory clinic by a physician

Description

Inclusion Criteria:

  • Being 60 years old and older
  • Ability to answer questions

Exclusion Criteria:

  • Opposition to the use of information collected for research purposes

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
cognitively healthy individuals (CHI)
CHI were participants without objective cognitive impairment
Other: gait and cognitive testing
mild cognitive impairment (MCI)
MCI was diagnosed if participants met the following criteria: presence of spontaneous cognitive complaints and objective cognitive impairment
Other: gait and cognitive testing
mild and moderate dementia
Diagnoses of dementia were assigned according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV TR, 2000; Association, 2000; 22) at consensus diagnostic case conferences
Other: gait and cognitive testing

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Spatio-temporal gait parameters
Time Frame: This outcome is assessed at inclusion
Spatio-temporal gait parameters were measured at steady state walking using GAITRite®-system.
This outcome is assessed at inclusion

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Clinical assessment
Time Frame: This outcome is assessed at inclusion
This outcome was assessed by a questionnaire.
This outcome is assessed at inclusion
Cognitive status
Time Frame: This outcome is assessed at inclusion
Cognitive status was assessed by cognitive testing.
This outcome is assessed at inclusion

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Angers

Collaborators

Biomathics

Investigators

  • Principal Investigator: Olivier Beauchet, MD, PhD, Angers University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2015

Primary Completion (Anticipated)

June 1, 2015

Study Completion (Anticipated)

December 1, 2015

Study Registration Dates

First Submitted

January 26, 2015

First Submitted That Met QC Criteria

January 28, 2015

First Posted (Estimate)

January 29, 2015

Study Record Updates

Last Update Posted (Estimate)

January 29, 2015

Last Update Submitted That Met QC Criteria

January 28, 2015

Last Verified

February 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2014-17

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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