Patients With Alzheimer Disease, Spouse Carers and Risk of Institutionalization: a Prospective Observational Cohort Study of Dyads (AID Study)

The primary objective of AID study is to identify the medico-neuropsychological, socio-economic and environmental baseline characteristics of dyads associated with the institutionalization of AD patients.

Study Overview

• Status: Completed
• Conditions: Alzheimer Disease

Detailed Description

In order to reduce Alzheimer Disease (AD) adverse impacts at individual level as well as in terms of expenditures, the development of efficient strategies based on the identification and the correction of risk factors of institutionalization of AD patients proves necessary.

While it has been identified that institutionalization date depends on patients' health characteristics, the role of social, economic and environmental factors still remains few known.

The investigators hypothesized that institutionalization of AD patients could be related not only to medico-neuropsychological patients' characteristics but also to socio-economic and environmental characteristics of dyad (i.e., AD patient and spouse carer), that could modify the delay of institutionalization.

• Study Type: Observational
• Enrollment (Actual): 207

Contacts and Locations

Study Locations

• France
  • Angers, France, 49933
    • University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

AD patients and their spouses were recruited in each memory clinic by a physician during the annual follow-up consultation of AD patient based on eligibility criteria.

Description

Inclusion Criteria:

• Eligibility criteria for AD patients were:

  • Over age 65,
  • Diagnosis of AD according to the NINCDS-ADRDA ( National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association) criteria,
  • Last memory center consultation between 6 and 12 months before the inclusion,
  • Being affiliated to the French health insurance,
  • Living at home,
  • Having a caregiver with inclusion criteria,
  • Agreement of General Practitioner (GP) of AD patient to participate in the study and affiliation of the GP to the national "Association pour le Développement de l'Information Médicalisée" (ADIM) French network.

• Eligibility criteria for spouse carers were:

  • Over age 65,
  • Being the spouse and the caregiver of AD patient,
  • Being affiliated to the French health insurance,
  • Living at home with AD patient.

Exclusion Criteria:

• Non inclusion criteria for AD patients and spouse carers were:

  • An inability to understand and speak French,
  • Acute disease in the past month of baseline assessment,
  • Expected moving outside the recruitment area during the follow-up period
  • Concomitant participation in a clinical trial.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Date of institutionalization of AD patients (standardized questionnaire)	Date of entrance in institution was collected by a standardized questionnaire.	This outcome is assessed at 12 months.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The increase formal home help services (measured by a standardized questionnaire and coded as a binary variable)	The use of formal home help services was measured by a standardized questionnaire and coded as a binary variable.	This outcome is assessed at baseline and 12 months.
The delay of institutionalization of AD patients (assessed by a standardized questionnaire and expressed in number of days)	The delay of institutionalization was assessed by a standardized questionnaire and expressed in number of days.	This outcome is assessed at baseline and 12 months.

Collaborators and Investigators

• Sponsor: University Hospital, Angers
• Investigators: Principal Investigator: Olivier Beauchet, MD, PhD, University Hospital, Angers

Study record dates

Study Major Dates

• Study Start: August 1, 2011
• Primary Completion (Actual): February 1, 2013
• Study Completion (Actual): February 1, 2013

Study Registration Dates

• First Submitted: January 13, 2015
• First Submitted That Met QC Criteria: January 29, 2015
• First Posted (Estimate): January 30, 2015

Study Record Updates

• Last Update Posted (Estimate): January 30, 2015
• Last Update Submitted That Met QC Criteria: January 29, 2015
• Last Verified: November 1, 2011

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Neurodegenerative Diseases; Dementia; Tauopathies; Alzheimer Disease
• Other Study ID Numbers: 2011/24