The Effects of Exercise of Secreted Factors From Muscle and Adipose Tissue

April 19, 2016 updated by: Laurie Goodyear, Joslin Diabetes Center

Investigation of Exercise-Induced Myokines and Adipokines

The purpose of this study is to find out whether exercise leads to changes in the blood that are produced by exercised muscles and if these changes produce new hormones that affect the body's regulation of sugar and body weight.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Recent work in the laboratory at the Joslin Diabetes Center and elsewhere has shown that when small animals exercise they improve their muscles and improve their blood sugar levels. Also, these animals show changes in their abdominal fat tissue, compared to animals that did not exercise. Our data suggest that factors released from exercised muscle and fat tissue from exercised mice also has a positive effect on other tissues in the same animal. Therefore, there could be new factors or hormones, which come from the trained animals' muscles or fat tissue and which exert a positive effect on the animals' blood sugar levels. Large studies with human volunteers have shown that exercise can improve blood sugar uptake into skeletal muscle and lower blood sugar levels, thereby preventing type 2 diabetes. The purpose if this study is to evaluate if a single exercise bout leads to changes in circulating factors in the blood. We plan to detect if there are hormones being produced in the body that have a beneficial effect elsewhere in the body.

Study Type

Interventional

Enrollment (Actual)

12

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Massachusetts
      • Boston, Massachusetts, United States, 02215
        • Joslin Diabetes Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 35 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

- Age between 18-35. Body mass index (BMI) must be ≥20 and ≤26 kg/m2. HbA1c values ≤5.7%

Exclusion Criteria:

- Age <18 and >35; HbA1c ≥ 5.7%; heart or lung disease; acute systemic infection accompanied by fever, body aches, or swollen lymph glands; BMI ≥ 26 kg/m2; current dieting or weight loss efforts; current pregnancy or breastfeeding; known history of HIV/AIDS; cancer; biochemical evidence of renal or hepatic dysfunction; renal or liver disease; demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis; recent blood donation; clinical history of stroke; hypertension (systolic > 140 mmHg or diastolic > 90 mmHg); type 1 or 2 diabetes; history of keloid formation inability to exercise at 50% of predicted heart rate (HR) reserve at baseline. Participants taking beta-blockers Participants who screen positive for The American Heart Association's contraindications to exercise testing

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Exercise intervention
Subjects will undergo an acute bout of exercise for 45 mins at 75% of peak aerobic capacity
Other: Exercise bout
Participants will exercise for 45min at 75% of VO2peak

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Changes in myokines/adipokine concentration
Time Frame: baseline, and 15, 45 and 1h:45 mins after exercise session.
baseline, and 15, 45 and 1h:45 mins after exercise session.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Joslin Diabetes Center

Collaborators

Daiichi Sankyo, Inc.

Investigators

  • Principal Investigator: Laurie J. Goodyear, Joslin Diabetes Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2015

Primary Completion (Actual)

March 1, 2016

Study Completion (Actual)

March 1, 2016

Study Registration Dates

First Submitted

September 30, 2015

First Submitted That Met QC Criteria

September 30, 2015

First Posted (Estimate)

October 1, 2015

Study Record Updates

Last Update Posted (Estimate)

April 21, 2016

Last Update Submitted That Met QC Criteria

April 19, 2016

Last Verified

April 1, 2016

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • CHS2015-11

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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