The Effects of Working Memory Training in Children With Attention-Deficit/Hyperactivity Disorder

October 25, 2017 updated by: I-hsuan Shen, Chang Gung Memorial Hospital
Previous studies indicated that children with attention-deficit/hyperactivity disorder (ADHD) often suffer from deficits in executive function, such as attentional control, inhibition, and working memory. One of these executive functions, working memory, plays a critical role in academic performance and classroom behavior. Working memory is essential for performing complex cognitive tasks such as comprehension, learning, and reasoning. Several studies have shown that training of working memory has positive effects for ADHD and other cognitive disorder in children. However, transfer effects across studies appear to be variable and inconsistent. Event-related potentials can be a useful tool to gain insights into such mechanism. Therefore, the aim of the present study is to investigate both near and far transfer effects of N-back training in children with ADHD. In addition, the recording and analysis of event-related potentials will be adopted while children with ADHD perform the complex visuo-spatial and phonological working memory tasks.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Taiwan
      • Taoyuan City, Taiwan
        • Chang Gung University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

8 years to 10 years (Child)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • ADHD diagnosed according to criteria specified in Diagnostic and statistical manual of mental disorders (DSM-5)
  • aged between 8 and 10 years
  • intelligence quotient > 80 (based on Test of Nonverbal Intelligence-Third Edition)
  • had normal or corrected-to-normal vision
  • right-handed

Exclusion Criteria:

  • diagnosis of clinically significant oppositional defiant disorder, Autistic Spectrum Disorders, Asperger's syndrome or depression
  • history of seizures

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Control
ADHD group treated with visual-perceptual training
Other: perceptual training
visual-perceptual training program
Experimental: Experiment
ADHD group treated with working memory training
Other: Working memory training
n-back training program

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Automated Working Memory Assessment
Time Frame: 6 weeks
Visuospatial working memory change after intervention measured by Automated Working Memory Assessment
6 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Working memory index in Wechsler Intelligence Scale for Children-IV
Time Frame: 6 weeks
Verbal working memory change after intervention measured by Working memory index in WISC-IV
6 weeks
Event-related potentials
Time Frame: 6 weeks
Event-related potentials are measured brain response on effects of working memory training
6 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Chang Gung Memorial Hospital

Investigators

  • Principal Investigator: I-Hsuan Shen, PhD, Chang Gung University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2015

Primary Completion (Actual)

November 25, 2016

Study Completion (Actual)

January 19, 2017

Study Registration Dates

First Submitted

October 31, 2016

First Submitted That Met QC Criteria

November 7, 2016

First Posted (Estimate)

November 9, 2016

Study Record Updates

Last Update Posted (Actual)

October 26, 2017

Last Update Submitted That Met QC Criteria

October 25, 2017

Last Verified

October 1, 2017

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 104-5308A3

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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