Involuntary Memories Investigation in Schizophrenia

Patients with schizophrenia suffer from autobiographical memory disorders. Patients have difficulty to remember vividly personal past events when they are specifically asked for. Indeed, this task requires a good executive functioning to retrieve precise information stored in long term memory. Interestingly, executive functioning has been showed impaired in schizophrenia and studies showed that their autobiographical memory impairments were directed related to their executive dysfunction.

Yet, in daily life people remember more often autobiographical memories spontaneously, without trying voluntarily to recall them.

In that case, the involuntary recall of personal past events is much less sustained by executive functioning.

In this protocol the investigators would like to investigate and compare subjective characteristics of involuntary and voluntary autobiographical memories in order to highlight the role of executive dysfunction in patients' autobiographical memory impairments.

Study Overview

• Status: Terminated
• Conditions: Schizophrenia
• Intervention / Treatment: Other: Patients with Schizophrenia

• Study Type: Interventional
• Enrollment (Actual): 65
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Strasbourg, France, 67000
    • Les Hôpitaux Universitaires

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 55 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• - for patients only
• male or female
• age limits : 18-55 years old
• under the protection of health insurance
• who have signed up the consent form
• schizophrenia or schizo-affective disorder according to the DSM-5 criteria (APA, 2013).
• clinically stable for at least 2 months
• patients under guardianship or curatorship need agreement of their legal representative
• informed of the results of prior medical examination for controls only
• male or female
• age limits : 18-55 years old
• under the protection of health insurance
• who have sign up the consent form
• recruited from the general population and matched on gender, age years of schooling
• no psychiatric history (DSM-5)

Exclusion Criteria:

• for both patients and controls
• current severe or unstable somatic illness
• neurological history (brain injury > 15 minutes loss of consciousness , epilepsia, brain surgery…)
• current substance use disorder (DSM-5)
• current major depressive disorder (CDSS,BDI, HDRS)
• mental retardation (IQ < 70, WAIS-4, f-NART)
• history of general anesthesia 3 months prior to the experiment
• pregnancy declared by the subject
• breast feeding
• current legal control
• in emergency situation
• included during exclusion period in another experiment
• for controls only
• taking of antipsychotic drugs for the 3 weeks prior to inclusion
• under guardianship or curatorship

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Control group; Control participants without psychiatric nor neurological history	Other: Patients with Schizophrenia; Patients with schizophrenia or schizoaffective disorder according to DSM-V criteria
Experimental: Patients with Schizophrenia; Patients with schizophrenia or schizoaffective disorder according to DSM-V criteria	Other: Patients with Schizophrenia; Patients with schizophrenia or schizoaffective disorder according to DSM-V criteria

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Autobiographical subjective score taking into account memories vividness and specifity	8 months

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France

Study record dates

Study Major Dates

• Study Start (Actual): September 29, 2017
• Primary Completion (Actual): December 15, 2019
• Study Completion (Actual): December 15, 2019

Study Registration Dates

• First Submitted: July 3, 2017
• First Submitted That Met QC Criteria: July 3, 2017
• First Posted (Actual): July 6, 2017

Study Record Updates

• Last Update Posted (Actual): September 20, 2021
• Last Update Submitted That Met QC Criteria: September 13, 2021
• Last Verified: September 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Schizophrenia Spectrum and Other Psychotic Disorders; Schizophrenia
• Other Study ID Numbers: 6620

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No