- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03259321
Fish, Polyunsaturated Fatty Acids Intake and Type 2 Diabetes
March 12, 2024 updated by: Jingjing Jiao, Zhejiang University
Fish, Polyunsaturated Fatty Acids Intake and Type 2 Diabetes in CHNS
The role of fishery diet and polyunsaturated fatty acids (PUFA) in the development of type 2 diabetes (T2D) is heavily debated but evidence from large populations in China is scant.
The investigators aim to use data from the China Health and Nutrition Survey (CHNS) to assess the long-term association between fish, PUFA intake and T2D risk.
Study Overview
Status
Completed
Conditions
Detailed Description
The role of fishery diet and polyunsaturated fatty acids (PUFA) in the development of T2D is heavily debated but evidence from large populations in China is still lacking.
The investigators aim to utilize data from China Health and Nutrition Survey (CHNS, 1997-2011).
The investigators will calculate cumulative means of fish and PUFA intake based on 3-day food records in each wave.
Sex-specific Cox regression models will be used to estimate relative risk of T2D.
Results from this work will provide epidemiological evidence for improving recommendations on fish and PUFA intake for Chinese in dietary guidelines.
Study Type
Observational
Enrollment (Actual)
15100
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Sampling Method
Probability Sample
Study Population
CHNS is an ongoing, large-scale, household-based cohort starting in 1989.
The survey used a multi-stage, random cluster process to draw a sample of 9 provinces and municipal cities, which take up about half of Chinese population.
Description
Inclusion Criteria:
- Adults aged ≥20 with complete data on diet and follow-up time
Exclusion Criteria:
- Missing information for Type 2 diabetes
- Type 2 diabetes
- Cardiovascular disease
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Type 2 diabetes
Time Frame: From entry into the study (baseline: 1997-2009) until 2011
|
Incidence of type 2 diabetes, on basis of self-reported physician diagnosis, fasting plasma glucose ≥ 7.0 mmol/l or HbA1c ≥ 6.5%
|
From entry into the study (baseline: 1997-2009) until 2011
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Fish and polyunsaturated fatty acids intake
Time Frame: From entry into the study (baseline: 1997-2009) until 2011
|
Cumulative averages of fish and PUFA intake based on 3-day 24-hr recall in each wave
|
From entry into the study (baseline: 1997-2009) until 2011
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Zhuang P, Mao L, Wu F, Wang J, Jiao J, Zhang Y. Cooking Oil Consumption Is Positively Associated with Risk of Type 2 Diabetes in a Chinese Nationwide Cohort Study. J Nutr. 2020 Jul 1;150(7):1799-1807. doi: 10.1093/jn/nxaa103. Erratum In: J Nutr. 2020 Sep 1;150(9):2490.
- Wu F, Mao L, Zhuang P, Chen X, Jiao J, Zhang Y. Plant-sourced cooking oil consumption is associated with lower total mortality in a longitudinal nationwide cohort study. Clin Nutr. 2020 Dec;39(12):3703-3710. doi: 10.1016/j.clnu.2020.03.031. Epub 2020 Apr 2.
- Zhuang P, Shou Q, Wang W, He L, Wang J, Chen J, Zhang Y, Jiao J. Essential Fatty Acids Linoleic Acid and alpha-Linolenic Acid Sex-Dependently Regulate Glucose Homeostasis in Obesity. Mol Nutr Food Res. 2018 Sep;62(17):e1800448. doi: 10.1002/mnfr.201800448. Epub 2018 Aug 12.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 1989
Primary Completion (Actual)
December 31, 2011
Study Completion (Actual)
December 31, 2012
Study Registration Dates
First Submitted
August 21, 2017
First Submitted That Met QC Criteria
August 21, 2017
First Posted (Actual)
August 23, 2017
Study Record Updates
Last Update Posted (Actual)
March 15, 2024
Last Update Submitted That Met QC Criteria
March 12, 2024
Last Verified
March 1, 2024
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- Cohort_PUFA_T2D
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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