- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03577080
Chronic Obstructive Pulmonary Disease (COPD)
September 5, 2019 updated by: Acheche Amal, Faculty of Medicine, Sousse
The Effect of Adding Neuromuscular Electrical Stimulation to Endurance and Resistance Training on Exercise Capacity and Balance in Patients With Chronic Obstructive Pulmonary Disease: a Randomized Clinical Trial
Chronic Obstructive Pulmonary Disease (COPD) is a preventable respiratory characterized by airflow obstruction that is not fully reversible. This disease a major cause of mortality worldwide. It is projected to rank the third-leading cause of death in 2020.
The objective of this study is to examine the effects of a physical therapy intervention in stable patients with COPD.
Study Overview
Detailed Description
Chronic obstructive pulmonary disease (COPD) patients have demonstrated important balance impairment (1).The deficit in balance control is identified as one of the risk factors of fall in subjects with COPD and alters their activities daily life (2,3).
Porto and al. (2015) reported in a recent review that individuals with COPD have a decline in balance control when compared with healthy age matched controls(4).
Study Type
Interventional
Enrollment (Actual)
42
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Sousse, Tunisia
- Research Unit of Exercise Physiology and Pathophysiology: from integral to molecular Biology, Medicine and Health (UR12 ES06) Faculty of Medicine of Sousse
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
40 years to 70 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- COPD diagnosed by pulmonary function testing
- Clinically stable
- Abscence of other obstructive diseases
- Signed written consent
- Fall in the past five years or recent near fall
Exclusion Criteria:
- Neuromuscular diseases
- Severe psychiatric, neurologic or musculoskeletal conditions and /or instable cardiovascular diseases.
- Contre-indications to physical therapy
- Acute exacerbations a month before the intervention
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: ET+RT+ NMES
neuromuscular electrical training NMES
|
Endurance training, resistance training and neuromuscular electrical stimuation were prformed.
Intensity was gradually increased.
|
Placebo Comparator: ET+RT
placebo neuromuscular electrical training NMES
|
Endurance training, resistance training and neuromuscular electrical stimuation were prformed.
Intensity was gradually increased.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Balance outcomes
Time Frame: baseline
|
The tests were performed using a stabilometric platform
|
baseline
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pulmonary function test
Time Frame: baseline
|
The test was performed using a Spirometry Zan 100 (Inspire Health GmbH, Germany)
|
baseline
|
Exercise tolerance
Time Frame: baseline
|
The 6 minutes walk test
|
baseline
|
Force assesment
Time Frame: Baselline
|
Maximal voluntary contraction (MVC) of the quadriceps muscle
|
Baselline
|
Time Up and Go (TUG)
Time Frame: Baseline
|
The patient initially sitting on an armless chair stand up walks 3 meters and returns and sit down again.
The time was recorded
|
Baseline
|
Berg Balance Scale (BBS)
Time Frame: Baseline
|
The BBS contains 14 items.
The score obtained from 0 to 56. from 0 to 20: high risk of falling , Above 56: No risk of falling
|
Baseline
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Amal Acheche, phd, Faculty of medecine Sousse
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Smith MD, Chang AT, Seale HE, Walsh JR, Hodges PW. Balance is impaired in people with chronic obstructive pulmonary disease. Gait Posture. 2010 Apr;31(4):456-60. doi: 10.1016/j.gaitpost.2010.01.022. Epub 2010 Mar 4.
- Beauchamp MK, Hill K, Goldstein RS, Janaudis-Ferreira T, Brooks D. Impairments in balance discriminate fallers from non-fallers in COPD. Respir Med. 2009 Dec;103(12):1885-91. doi: 10.1016/j.rmed.2009.06.008. Epub 2009 Jul 9.
- Roig M, Eng JJ, MacIntyre DL, Road JD, FitzGerald JM, Burns J, Reid WD. Falls in people with chronic obstructive pulmonary disease: an observational cohort study. Respir Med. 2011 Mar;105(3):461-9. doi: 10.1016/j.rmed.2010.08.015.
- Porto EF, Castro AA, Schmidt VG, Rabelo HM, Kumpel C, Nascimento OA, Jardim JR. Postural control in chronic obstructive pulmonary disease: a systematic review. Int J Chron Obstruct Pulmon Dis. 2015 Jun 29;10:1233-9. doi: 10.2147/COPD.S63955. eCollection 2015.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 28, 2016
Primary Completion (Actual)
June 1, 2017
Study Completion (Actual)
June 10, 2017
Study Registration Dates
First Submitted
June 5, 2018
First Submitted That Met QC Criteria
July 2, 2018
First Posted (Actual)
July 5, 2018
Study Record Updates
Last Update Posted (Actual)
September 9, 2019
Last Update Submitted That Met QC Criteria
September 5, 2019
Last Verified
September 1, 2019
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- COPD
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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