Insulin- and Glucose Metabolism in Pulmonary Arterial Hypertension

Insulin- and Glucose Metabolism in Pulmonary Arterial Hypertension - a Pilot Study

Insulin resistance is a key mechanism in metabolic disorders, which has also been implicated in the development of pulmonary hypertension. In this pilot study, the investigators´ goal is to directly determine insulin sensitivity in idiopathic pulmonary arterial hypertension patients and to compare the results with data from healthy controls.

Study Overview

• Status: Completed
• Conditions: Insulin Resistance

• Study Type: Observational
• Enrollment (Actual): 10

Contacts and Locations

Study Locations

• Austria
  • Steiermark
    • Graz, Steiermark, Austria, 8010
      • Medical University Graz, Division of Pulmonology

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 90 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Healthy controls, or patients with idiopathic or hereditary pulmonary hypertension

Description

Inclusion Criteria:

• signed informed consent form
• patients with idiopathic or hereditary pulmonary hypertension / healthy controls

Exclusion Criteria:

• premenopausal women
• other relevant lung disease
• relevant left heart disease
• untreated systemic hypertension
• Diabetes mellitus
• pulmonary hypertension other than idiopathic or hereditary form

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Idiopathic Pulmonary Arterial Hypertension patients; Blood sampling Insulin resistance-measurement
Healthy controls; Blood sampling Insulin resistance-measurement

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Insulin resistance	Determination of insulin sensitivity using hyperinsulinemic-euglycemic clamp technique	1 day

Collaborators and Investigators

• Sponsor: Medical University of Graz
• Investigators: Principal Investigator: Bence M. Nagy, PhD, Medical University of Graz

Publications and helpful links

General Publications

• Nagy BM, Kovacs G, Tornyos A, Svehlikova E, Foris V, Nagaraj C, Kwapiszewska G, Pieber TR, Olschewski A, Olschewski H. No indication of insulin resistance in idiopathic pulmonary arterial hypertension with preserved physical activity. Eur Respir J. 2020 Jun 11;55(6):1901228. doi: 10.1183/13993003.01228-2019. Print 2020 Jun. No abstract available.

Study record dates

Study Major Dates

• Study Start (ACTUAL): December 20, 2017
• Primary Completion (ACTUAL): February 11, 2019
• Study Completion (ACTUAL): February 11, 2019

Study Registration Dates

• First Submitted: May 14, 2018
• First Submitted That Met QC Criteria: July 11, 2018
• First Posted (ACTUAL): July 12, 2018

Study Record Updates

• Last Update Posted (ACTUAL): January 27, 2020
• Last Update Submitted That Met QC Criteria: January 24, 2020
• Last Verified: January 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Respiratory Tract Diseases; Lung Diseases; Hyperinsulinism; Hypertension, Pulmonary; Hypertension; Insulin Resistance; Pulmonary Arterial Hypertension
• Other Study ID Numbers: 29-066 ex 16/17

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No