- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03637452
Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability
Study Overview
Status
Conditions
Detailed Description
Participants will be provided information about the study and will provide initial consent for screening via an online screener. Written consent will be completed in person when participants are present to the laboratory. Eligible participants will include anyone over the age of 18 years and those who exclusively use combustible cigarettes or those who dual use e-cigarettes and combustible cigarettes. For the exclusive cigarette group, we will allow some e-cigarette experimentation. Participants will complete three in-lab study visits (1 screener visit and 2 study visits) separated by a standard minimum 48-hour washout period. They will be offered an Uber or other rideshare service as transportation to each study visit, however, they will not be required to use the service.
Participants will complete an in-person screening visit in which they will be rescreened according to the eligibility criteria. Their exhaled carbon monoxide (eCO) will be checked prior to their visits as well as breath alcohol and urine pregnancy (for females) test will be conducted. Participant will also complete baseline assessment measures and Balloon Analog Risk Task (BART)- computerized task measuring impulsivity. At visit 2, participants will complete a standard 10 puff bout with the three e-cigarette devices and their usual brand cigarette. During visit 3, participants will complete three concurrent choice tasks in a counter-balanced fashion.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Oklahoma
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Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center Tobacco Research Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- be at least 18 years old
- live within 30 miles of the research site
- interested in/willing to use an e-cigarette during study visits
- be willing and able to complete study procedures including specimen collection, survey completion, and remaining nicotine abstinent for 12 hours prior to each study visit
- speak and understand English
- willing to provide informed consent
- bring usual brand cigarettes to screener study visit
- should have healthy veins
Additional Inclusion criteria for smokers:
- smoke at least 10 cigarettes per day for the past three months
- exhaled more than equal to 6 ppm carbon monoxide at the screener visit
Additional Inclusion criteria for dual users:
- smoke more than equal to 5 tobacco cigarettes per day for the last 3 months
- use e-cigarettes at least 15 days per month for the last 3 months, and
- bring e-cigarette device to screener study visit
Exclusion Criteria:
- currently suffering from lung disease including asthma, cystic fibrosis (CF), or chronic obstructive pulmonary disease (COPD), unless it is well-controlled
- currently pregnant or breast-feeding or have plans to become pregnant or begin breast-feeding at any point during the study
- intoxicated at study visits (breath alcohol testing and clean urine drug screen)
- any known allergies or sensitivity to the known major constituents contained in the aerosol of the study e-cigarette devices (e.g., flavorants, vegetable glycerin, propylene glycol)
- User of zero-nicotine e-cigarettes
- history of cardiac event or distress within the past 3 months
- currently suffering from any blood disorder that includes von willebrand, hemophilia, anemia, sickle cell, leukopenia, thrombocytopenia
- currently taking an anticoagulant or blood thinning medications
- have stent, graph, mastectomy or artificial hardware placed in arms or hands (bilaterally)
Additional Exclusion criteria for smokers:
- have previously used any e-cigarette device (cig-a-like, pen style, mod, APV) for longer than 30 days
- use of an e-cigarette device over the past 14 days.
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Cross-Sectional
Cohorts and Interventions
Group / Cohort |
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Exclusive cigarette smokers
Exclusive cigarette smokers must smoke at least 10 cigarettes per day for the past three months and have exhaled carbon monoxide (eCO) levels of at least 6 ppm at the screening visit.
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Dual (Electronic cigarette and cigarette smoking) users
Dual e-cigarette and cigarette users must have smoked at least 5 cigarettes per day for the last 3 months and use e-cigarettes at least 15 days per month for the last 3 months.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Proportion of puffs earned and allocated to each product in three hypothetical tobacco regulatory scenarios
Time Frame: 1 month
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Participants will complete three computer tasks simulating hypothetical regulatory scenarios and will earn and allocate puffs to study products.
A greater proportion of puffs allocated will indicate greater demand for the product in that hypothetical scenario
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1 month
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Nicotine delivery measured by serum (blood) nicotine
Time Frame: 1 month
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Participants will complete one standardized puffing bout (10 puffs) with each of the three electronic cigarettes and their usual brand cigarette.
Serum nicotine will be measured throughout each standardized puffing bout.
Greater levels of serum nicotine will be indicative of greater nicotine delivery.
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1 month
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Theodore Wagener, PhD, University of Oklahoma
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 8988
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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