Testing the Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia
May 28, 2026 updated by: National Cancer Institute (NCI)
A Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib Plus Venetoclax and Obinutuzumab in Untreated Older Patients (>/= 65 Years of Age) With Chronic Lymphocytic Leukemia (CLL)
This phase III trial compares adding a new anti-cancer drug (venetoclax) to the usual treatment (ibrutinib plus obinutuzumab) in older patients with chronic lymphocytic leukemia who have not received previous treatment.
The addition of venetoclax to the usual treatment might prevent chronic lymphocytic leukemia from returning.
This trial also will investigate whether patients who receive ibrutinib plus obinutuzumab plus venetoclax and have no detectable chronic lymphocytic leukemia after 1 year of treatment, can stop taking ibrutinib.
Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Immunotherapy with obinutuzumab may induce changes in body's immune system and may interfere with the ability of cancer cells to grow and spread.
Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors.
It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival.
Giving ibrutinib and obinutuzumab with venetoclax may work better at treating chronic lymphocytic leukemia compared to ibrutinib and obinutuzumab.
Study Overview
Status
Active, not recruiting
Intervention / Treatment
Detailed Description
PRIMARY OBJECTIVE:
I. To compare the progression-free survival (PFS) between control treatment and experimental treatment strategies: ibrutinib/obinutuzumab (IO) with ibrutinib maintenance (IM) versus ibrutinib/venetoclax/obinutuzumab (IVO) regardless of IM or observation.
SECONDARY OBJECTIVES:
I. To compare bone marrow (BM) minimal residual disease (MRD)- complete response (CR) rates, MRD- rates, and depth of response at cycle 15 day 1 between patients treated with IO versus IVO.
II. To compare overall survival (OS) between the control and experimental treatment strategies: IO with IM versus IVO regardless of IM or observation.
III. To compare the 5-year PFS and overall survival (OS) for the control and experimental treatment strategies: IO with IM versus IVO regardless of IM or observation.
IV. To describe the toxicity profile for each of the treatment strategies and by each treatment course.
CORRELATIVES SCIENCE OBJECTIVES:
I. To compare MRD status between blood and bone marrow at the end of induction treatment/cycle 15 day 1 to determine whether blood MRD can be used as a surrogate to bone marrow MRD with these treatment regimens.
II. To compare peripheral blood MRD status by standard central flow cytometry to next generation sequencing (NGS) using ClonoSeq technique to determine the agreement in MRD negativity of the two techniques.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive ibrutinib orally (PO) once daily (QD) on days 1-28. Patients also receive obinutuzumab intravenously (IV) on days 1, 2, 8, and 15 of cycle 1, and on day 1 of cycles 2-6. Treatment repeats every 28 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. Beginning cycle 15, patients receive ibrutinib PO QD every 28 days in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive ibrutinib PO QD on days 1-28. Patients also receive obinutuzumab IV on days 1, 2, 8, and 15 of cycle 1, and on day 1 of cycles 2-6. Beginning cycle 3, patients also receive venetoclax PO QD on days 1-28. Treatment repeats every 28 days for 14 cycles in the absence of disease progression or unacceptable toxicity. All patients will then receive a 15th cycle of ibrutinib. Beginning cycle 16, patients who do not achieve a BM MRD negative CR, receive ibrutinib PO QD every 28 days in the absence of disease progression or unacceptable toxicity. Patients who achieve a BM MRD negative CR undergo observation every 3 cycles for 6 years, then every 6 cycles thereafter.
After completion of study treatment, patients are followed every 6 months until 10 years from registration.
Study Type
Interventional
Enrollment (Actual)
465
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Alabama
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Birmingham, Alabama, United States, 35233
- University of Alabama at Birmingham Cancer Center
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Alaska
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Anchorage, Alaska, United States, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, United States, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, United States, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, United States, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, United States, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, United States, 99508
- Katmai Oncology Group
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Anchorage, Alaska, United States, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, United States, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, United States, 99701
- Fairbanks Memorial Hospital
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Arizona
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Kingman, Arizona, United States, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, United States, 85054
- Mayo Clinic Hospital in Arizona
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Phoenix, Arizona, United States, 85004
- Cancer Center at Saint Joseph's
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Scottsdale, Arizona, United States, 85259
- Mayo Clinic in Arizona
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Tucson, Arizona, United States, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, United States, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, United States, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Fort Smith, Arkansas, United States, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, United States, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Little Rock, Arkansas, United States, 72205
- John L McClellan Memorial Veterans Hospital
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California
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Anaheim, California, United States, 92806
- Kaiser Permanente-Anaheim
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Arroyo Grande, California, United States, 93420
- PCR Oncology
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Arroyo Grande, California, United States, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Baldwin Park, California, United States, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, United States, 90706
- Kaiser Permanente-Bellflower
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Burbank, California, United States, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Clovis, California, United States, 93611
- Community Cancer Institute
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Clovis, California, United States, 93611
- University Oncology Associates
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Costa Mesa, California, United States, 92627
- UC Irvine Health Cancer Center-Newport
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Duarte, California, United States, 91010
- City of Hope Comprehensive Cancer Center
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Fontana, California, United States, 92335
- Kaiser Permanente-Fontana
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Harbor City, California, United States, 90710
- Kaiser Permanente South Bay
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Irvine, California, United States, 92618
- Kaiser Permanente-Irvine
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Long Beach, California, United States, 90822
- Tibor Rubin VA Medical Center
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Los Angeles, California, United States, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, United States, 90034
- Kaiser Permanente West Los Angeles
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Ontario, California, United States, 91761
- Kaiser Permanente-Ontario
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Orange, California, United States, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Palm Springs, California, United States, 92262
- Desert Regional Medical Center
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Palo Alto, California, United States, 94304
- Stanford Cancer Institute Palo Alto
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Panorama City, California, United States, 91402
- Kaiser Permanente - Panorama City
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Riverside, California, United States, 92505
- Kaiser Permanente-Riverside
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San Diego, California, United States, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, United States, 92108
- Kaiser Permanente-San Diego Mission
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San Luis Obispo, California, United States, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Marcos, California, United States, 92078
- Kaiser Permanente-San Marcos
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Santa Maria, California, United States, 93444
- Mission Hope Medical Oncology - Santa Maria
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Woodland Hills, California, United States, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, United States, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, United States, 80012
- The Medical Center of Aurora
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Aurora, Colorado, United States, 80045
- Rocky Mountain Regional VA Medical Center
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Boulder, Colorado, United States, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, United States, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, United States, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, United States, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, United States, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, United States, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, United States, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, United States, 80220
- Rose Medical Center
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Denver, Colorado, United States, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, United States, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, United States, 80204
- Denver Health Medical Center
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Denver, Colorado, United States, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, United States, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, United States, 80209
- The Women's Imaging Center
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Denver, Colorado, United States, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, United States, 80220
- Western Surgical Care
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Denver, Colorado, United States, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, United States, 80210
- AdventHealth Porter
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Durango, Colorado, United States, 81301
- Mercy Medical Center
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Durango, Colorado, United States, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, United States, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, United States, 80113
- Swedish Medical Center
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Englewood, Colorado, United States, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, United States, 80113
- The Melanoma and Skin Cancer Institute
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Golden, Colorado, United States, 80401
- Mountain Blue Cancer Care Center
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Golden, Colorado, United States, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, United States, 81501
- Saint Mary's Hospital and Regional Medical Center
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Grand Junction, Colorado, United States, 81505
- Grand Valley Oncology
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Greeley, Colorado, United States, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, United States, 80026
- Kaiser Permanente-Rock Creek
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Lafayette, Colorado, United States, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, United States, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, United States, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, United States, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, United States, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, United States, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, United States, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, United States, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, United States, 80501
- Longmont United Hospital
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Longmont, Colorado, United States, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, United States, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, United States, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, United States, 80138
- AdventHealth Parker
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Pueblo, Colorado, United States, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, United States, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, United States, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, United States, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, United States, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Derby, Connecticut, United States, 06418
- Smilow Cancer Hospital-Derby Care Center
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Fairfield, Connecticut, United States, 06824
- Smilow Cancer Hospital Care Center-Fairfield
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Glastonbury, Connecticut, United States, 06033
- Smilow Cancer Hospital Care Center at Glastonbury
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Guilford, Connecticut, United States, 06437
- Smilow Cancer Hospital Care Center - Guilford
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Hartford, Connecticut, United States, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Haven, Connecticut, United States, 06520
- Yale University
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New Haven, Connecticut, United States, 06510
- Smilow Cancer Center/Yale-New Haven Hospital
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North Haven, Connecticut, United States, 06473
- Yale-New Haven Hospital North Haven Medical Center
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Orange, Connecticut, United States, 06477
- Smilow Cancer Hospital-Orange Care Center
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Trumbull, Connecticut, United States, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterbury, Connecticut, United States, 06708
- Smilow Cancer Hospital-Waterbury Care Center
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Waterford, Connecticut, United States, 06385
- Smilow Cancer Hospital Care Center - Waterford
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West Haven, Connecticut, United States, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
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Delaware
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Lewes, Delaware, United States, 19958
- Beebe Medical Center
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Millville, Delaware, United States, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, United States, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, United States, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, United States, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, United States, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, United States, 19971
- Beebe Health Campus
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Seaford, Delaware, United States, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, United States, 19801
- Christiana Care Health System-Wilmington Hospital
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Florida
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Coral Gables, Florida, United States, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Deerfield Beach, Florida, United States, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Deerfield Beach, Florida, United States, 33064
- Broward Health North
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Fort Lauderdale, Florida, United States, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, United States, 33308
- Holy Cross Hospital
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Hollywood, Florida, United States, 33021
- UM Sylvester Comprehensive Cancer Center at Hollywood
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Miami, Florida, United States, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Plantation, Florida, United States, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
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Weston, Florida, United States, 33331
- Cleveland Clinic-Weston
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Georgia
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Athens, Georgia, United States, 30607
- University Cancer and Blood Center LLC
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Augusta, Georgia, United States, 30912
- Augusta University Medical Center
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Augusta, Georgia, United States, 30901
- Augusta Oncology Associates PC-D'Antignac
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Augusta, Georgia, United States, 30909
- Augusta Oncology Associates PC-Wheeler
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Decatur, Georgia, United States, 30033
- Atlanta VA Medical Center
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Savannah, Georgia, United States, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Hawaii
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Hilo, Hawaii, United States, 96720
- Island Urology-Hilo
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Honolulu, Hawaii, United States, 96813
- Queen's Medical Center
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Honolulu, Hawaii, United States, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, United States, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, United States, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, United States, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, United States, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, United States, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, United States, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, United States, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, United States, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, United States, 96813
- Island Urology
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Lihue, Hawaii, United States, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, United States, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, United States, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, United States, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, United States, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, United States, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, United States, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, United States, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, United States, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, United States, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, United States, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, United States, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, United States, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, United States, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, United States, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, United States, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, United States, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, United States, 62002
- OSF Saint Anthony's Health Center
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Aurora, Illinois, United States, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, United States, 61704
- Illinois CancerCare-Bloomington
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Burr Ridge, Illinois, United States, 60527
- Loyola Center for Health at Burr Ridge
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Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, United States, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, United States, 62918
- SIH Cancer Institute
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Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, United States, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, United States, 60611
- Northwestern University
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Chicago, Illinois, United States, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, United States, 60612
- University of Illinois
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Chicago, Illinois, United States, 60612
- Rush MD Anderson Cancer Center
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Danville, Illinois, United States, 61832
- Carle at The Riverfront
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DeKalb, Illinois, United States, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, United States, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, United States, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, United States, 62401
- Crossroads Cancer Center
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Effingham, Illinois, United States, 62401
- Carle Physician Group-Effingham
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Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, United States, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, United States, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, United States, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, United States, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, United States, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Harvey, Illinois, United States, 60426
- Ingalls Memorial Hospital
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Highland Park, Illinois, United States, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Homer Glen, Illinois, United States, 60491
- Loyola Medicine Homer Glen
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Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, United States, 60045
- Northwestern Medicine Lake Forest Hospital
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Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, United States, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, United States, 60153
- Loyola University Medical Center
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Melrose Park, Illinois, United States, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
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Mount Vernon, Illinois, United States, 62864
- SSM Health Good Samaritan
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New Lenox, Illinois, United States, 60451
- UC Comprehensive Cancer Center at Silver Cross
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O'Fallon, Illinois, United States, 62269
- Cancer Care Center of O'Fallon
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Orland Park, Illinois, United States, 60462
- University of Chicago Medicine-Orland Park
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Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, United States, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, United States, 61554
- OSF Saint Francis Radiation Oncology at Pekin
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Peoria, Illinois, United States, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, United States, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, United States, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, United States, 61354
- Valley Radiation Oncology
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Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
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Rockford, Illinois, United States, 61114
- UW Health Carbone Cancer Center Rockford
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Skokie, Illinois, United States, 60076
- North Shore Medical Center
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Springfield, Illinois, United States, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, United States, 62702
- Springfield Clinic
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Springfield, Illinois, United States, 62781
- Springfield Memorial Hospital
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Swansea, Illinois, United States, 62226
- Southwest Illinois Health Services LLP
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Urbana, Illinois, United States, 61801
- Carle Cancer Center
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Urbana, Illinois, United States, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, United States, 60555
- Northwestern Medicine Cancer Center Warrenville
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Washington, Illinois, United States, 61571
- Illinois CancerCare - Washington
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Yorkville, Illinois, United States, 60560
- Rush-Copley Healthcare Center
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Indiana
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Indianapolis, Indiana, United States, 46237
- Franciscan Health Indianapolis
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Mooresville, Indiana, United States, 46158
- Franciscan Health Mooresville
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Richmond, Indiana, United States, 47374
- Reid Health
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Iowa
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Ames, Iowa, United States, 50010
- Mary Greeley Medical Center
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Ames, Iowa, United States, 50010
- McFarland Clinic - Ames
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Bettendorf, Iowa, United States, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
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Boone, Iowa, United States, 50036
- McFarland Clinic - Boone
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Cedar Rapids, Iowa, United States, 52402
- Physicians' Clinic of Iowa PC
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Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
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Clive, Iowa, United States, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
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Council Bluffs, Iowa, United States, 51503
- Alegent Health Mercy Hospital
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Creston, Iowa, United States, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, United States, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, United States, 50501
- McFarland Clinic - Trinity Cancer Center
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Iowa City, Iowa, United States, 52242
- University of Iowa/Holden Comprehensive Cancer Center
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Jefferson, Iowa, United States, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, United States, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, United States, 51101
- Siouxland Regional Cancer Center
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Waterloo, Iowa, United States, 50702
- MercyOne Waterloo Cancer Center
-
West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
-
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Kansas
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Coffeyville, Kansas, United States, 67337
- Coffeyville Regional Medical Center
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Garden City, Kansas, United States, 67846
- Central Care Cancer Center - Garden City
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Great Bend, Kansas, United States, 67530
- Central Care Cancer Center - Great Bend
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Hays, Kansas, United States, 67601
- HaysMed
-
Independence, Kansas, United States, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, United States, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, United States, 66112
- University of Kansas Cancer Center-West
-
Lawrence, Kansas, United States, 66044
- Lawrence Memorial Hospital
-
Lenexa, Kansas, United States, 66219
- Kansas Institute of Medicine Cancer and Blood Center
-
Lenexa, Kansas, United States, 66219
- Minimally Invasive Surgery Hospital
-
Olathe, Kansas, United States, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, United States, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, United States, 66209
- Menorah Medical Center
-
Pittsburg, Kansas, United States, 66762
- Mercy Hospital Pittsburg
-
Salina, Kansas, United States, 67401
- Salina Regional Health Center
-
Topeka, Kansas, United States, 66606
- University of Kansas Health System Saint Francis Campus
-
Westwood, Kansas, United States, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, United States, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, United States, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, United States, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, United States, 67214
- Wesley Medical Center
-
-
Kentucky
-
Bardstown, Kentucky, United States, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, United States, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, United States, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, United States, 40509
- Saint Joseph Hospital East
-
London, Kentucky, United States, 40741
- Saint Joseph London
-
Louisville, Kentucky, United States, 40202
- Jewish Hospital
-
Louisville, Kentucky, United States, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, United States, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, United States, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Alexandria, Louisiana, United States, 71301
- Christus Saint Frances Cabrini Hospital
-
New Orleans, Louisiana, United States, 70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Bangor, Maine, United States, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, United States, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore, Maryland, United States, 21201
- University of Maryland/Greenebaum Cancer Center
-
Baltimore, Maryland, United States, 21229
- Saint Agnes Hospital
-
Cumberland, Maryland, United States, 21502
- UPMC Western Maryland
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02111
- Tufts Medical Center
-
Burlington, Massachusetts, United States, 01805
- Lahey Hospital and Medical Center
-
Lowell, Massachusetts, United States, 01854
- Lowell General Hospital
-
Springfield, Massachusetts, United States, 01199
- Baystate Medical Center
-
Springfield, Massachusetts, United States, 01104
- Mercy Medical Center
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, United States, 49017
- Bronson Battle Creek
-
Brighton, Michigan, United States, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, United States, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, United States, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, United States, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, United States, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, United States, 48723
- Caro Cancer Center
-
Chelsea, Michigan, United States, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, United States, 48118
- Chelsea Hospital
-
Clarkston, Michigan, United States, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, United States, 48346
- Newland Medical Associates-Clarkston
-
Clinton Township, Michigan, United States, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, United States, 48126
- Henry Ford Medical Center-Fairlane
-
Dearborn, Michigan, United States, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, United States, 48202
- Henry Ford Hospital
-
Detroit, Michigan, United States, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, United States, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, United States, 48054
- Henry Ford River District Hospital
-
Escanaba, Michigan, United States, 49829
- OSF Saint Francis Hospital and Medical Group
-
Farmington Hills, Michigan, United States, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, United States, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, United States, 48503
- Hurley Medical Center
-
Flint, Michigan, United States, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, United States, 48503
- Cancer Hematology Centers - Flint
-
Grand Rapids, Michigan, United States, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, United States, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, United States, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe, Michigan, United States, 48230
- William Beaumont Hospital-Grosse Pointe
-
Grosse Pointe Woods, Michigan, United States, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, United States, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, United States, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, United States, 49201
- Allegiance Health
-
Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, United States, 49009
- Beacon Kalamazoo Cancer Center
-
Kalamazoo, Michigan, United States, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, United States, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, United States, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, United States, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, United States, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, United States, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, United States, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Muskegon, Michigan, United States, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, United States, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, United States, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi, Michigan, United States, 48377
- Henry Ford Medical Center-Columbus
-
Pontiac, Michigan, United States, 48341
- Hope Cancer Center
-
Pontiac, Michigan, United States, 48341
- Newland Medical Associates-Pontiac
-
Pontiac, Michigan, United States, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, United States, 48341
- Michigan Healthcare Professionals Pontiac
-
Reed City, Michigan, United States, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, United States, 48309
- Henry Ford Rochester Hospital
-
Roseville, Michigan, United States, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, United States, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, United States, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, United States, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, United States, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, United States, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, United States, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, United States, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, United States, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, United States, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, United States, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Shelby, Michigan, United States, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Sterling Heights, Michigan, United States, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Sterling Heights, Michigan, United States, 48312
- Premier Hematology Oncology Care
-
Tawas City, Michigan, United States, 48764
- MyMichigan Medical Center Tawas
-
Traverse City, Michigan, United States, 49684
- Munson Medical Center
-
Troy, Michigan, United States, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, United States, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, United States, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, United States, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, United States, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, United States, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, United States, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, United States, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Bloomfield, Michigan, United States, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, United States, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, United States, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, United States, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, United States, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, United States, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, United States, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, United States, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, United States, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, United States, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, United States, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
-
Deer River, Minnesota, United States, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, United States, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, United States, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, United States, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, United States, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, United States, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, United States, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, United States, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, United States, 55432
- Unity Hospital
-
Hibbing, Minnesota, United States, 55746
- Essentia Health Hibbing Clinic
-
Mankato, Minnesota, United States, 56001
- Mayo Clinic Health Systems-Mankato
-
Maple Grove, Minnesota, United States, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, United States, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, United States, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, United States, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, United States, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, United States, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, United States, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, United States, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, United States, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, United States, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, United States, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, United States, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, United States, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, United States, 55101
- Regions Hospital
-
Saint Paul, Minnesota, United States, 55102
- United Hospital
-
Sandstone, Minnesota, United States, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, United States, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, United States, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, United States, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, United States, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, United States, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, United States, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, United States, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, United States, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, United States, 55092
- Fairview Lakes Medical Center
-
-
Missouri
-
Ballwin, Missouri, United States, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, United States, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, United States, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, United States, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, United States, 63703
- Mercy Cancer Center - Cape Girardeau
-
City of Saint Peters, Missouri, United States, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Creve Coeur, Missouri, United States, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, United States, 63640
- Parkland Health Center - Farmington
-
Independence, Missouri, United States, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, United States, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, United States, 64804
- Freeman Health System
-
Joplin, Missouri, United States, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, United States, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, United States, 64132
- Research Medical Center
-
Kansas City, Missouri, United States, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, United States, 64064
- University of Kansas Cancer Center - Lee's Summit
-
North Kansas City, Missouri, United States, 64116
- University of Kansas Cancer Center at North Kansas City Hospital
-
Rolla, Missouri, United States, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, United States, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, United States, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, United States, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, United States, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, United States, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, United States, 63110
- Washington University School of Medicine
-
St Louis, Missouri, United States, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, United States, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, United States, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, United States, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, United States, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, United States, 63128
- Mercy Hospital South
-
Sullivan, Missouri, United States, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, United States, 63127
- BJC Outpatient Center at Sunset Hills
-
Washington, Missouri, United States, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, United States, 59711
- Community Hospital of Anaconda
-
Billings, Montana, United States, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, United States, 59101
- Saint Vincent Healthcare
-
Billings, Montana, United States, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, United States, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, United States, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, United States, 59405
- Great Falls Clinic
-
Great Falls, Montana, United States, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, United States, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, United States, 59901
- Logan Health Medical Center
-
Missoula, Montana, United States, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, United States, 59804
- Community Medical Center
-
-
Nebraska
-
Bellevue, Nebraska, United States, 68123
- Nebraska Medicine-Bellevue
-
Grand Island, Nebraska, United States, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, United States, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, United States, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, United States, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, United States, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, United States, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, United States, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, United States, 68118
- Nebraska Medicine-Village Pointe
-
Omaha, Nebraska, United States, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, United States, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, United States, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, United States, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, United States, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, United States, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, United States, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, United States, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, United States, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, United States, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, United States, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, United States, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, United States, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, United States, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, United States, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, United States, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, United States, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, United States, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, United States, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, United States, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, United States, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, United States, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, United States, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, United States, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, United States, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, United States, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, United States, 89102
- Desert West Surgery
-
Las Vegas, Nevada, United States, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, United States, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, United States, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, United States, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, United States, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, United States, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, United States, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89169
- University Cancer Center
-
Las Vegas, Nevada, United States, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, United States, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, United States, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, United States, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, United States, 89502
- Renown Regional Medical Center
-
Reno, Nevada, United States, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, United States, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, United States, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Manchester, New Hampshire, United States, 03103
- Solinsky Center for Cancer Care
-
-
New Jersey
-
Lakewood, New Jersey, United States, 08701
- Monmouth Medical Center Southern Campus
-
Long Branch, New Jersey, United States, 07740
- Monmouth Medical Center
-
Morristown, New Jersey, United States, 07960
- Morristown Medical Center
-
New Brunswick, New Jersey, United States, 08903
- Rutgers Cancer Institute of New Jersey
-
Paramus, New Jersey, United States, 07652
- The Valley Hospital - Luckow Pavilion
-
Ridgewood, New Jersey, United States, 07450
- Neurosurgeons of New Jersey-Ridgewood
-
Ridgewood, New Jersey, United States, 07450
- Valley Health System Ridgewood Campus
-
Summit, New Jersey, United States, 07902
- Overlook Hospital
-
Westwood, New Jersey, United States, 07675
- Valley Health System-Hematology/Oncology
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87106
- University of New Mexico Cancer Center
-
Las Cruces, New Mexico, United States, 88011
- Memorial Medical Center-Las Cruces
-
-
New York
-
Auburn, New York, United States, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Buffalo, New York, United States, 14263
- Roswell Park Cancer Institute
-
Camillus, New York, United States, 13031
- Hematology Oncology Associates of CNY at Camillus
-
East Hills, New York, United States, 11548
- The Cancer Institute at Saint Francis Hospital
-
East Syracuse, New York, United States, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, United States, 12801
- Glens Falls Hospital
-
Lake Success, New York, United States, 11042
- Northwell Health/Center for Advanced Medicine
-
Manhasset, New York, United States, 11030
- North Shore University Hospital
-
New Hyde Park, New York, United States, 11040
- Long Island Jewish Medical Center
-
New York, New York, United States, 10065
- NYP/Weill Cornell Medical Center
-
Rochester, New York, United States, 14642
- University of Rochester
-
Syracuse, New York, United States, 13210
- State University of New York Upstate Medical University
-
Verona, New York, United States, 13478
- Upstate Cancer Center at Verona
-
West Islip, New York, United States, 11795
- Good Samaritan University Hospital
-
-
North Carolina
-
Asheville, North Carolina, United States, 28801
- Mission Hospital
-
Asheville, North Carolina, United States, 28806
- Messino Cancer Centers
-
Cary, North Carolina, United States, 27518
- Waverly Hematology Oncology
-
Chapel Hill, North Carolina, United States, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clemmons, North Carolina, United States, 27012
- Wake Forest University at Clemmons
-
Clinton, North Carolina, United States, 28328
- Southeastern Medical Oncology Center-Clinton
-
Durham, North Carolina, United States, 27710
- Duke University Medical Center
-
Goldsboro, North Carolina, United States, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, United States, 27534
- Wayne Memorial Hospital
-
Greenville, North Carolina, United States, 27834
- East Carolina University
-
Hendersonville, North Carolina, United States, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, United States, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, United States, 28546
- Onslow Memorial Hospital
-
Kenansville, North Carolina, United States, 28349
- ECU Health Oncology Kenansville
-
Kernersville, North Carolina, United States, 27284
- Novant Health Cancer Institute - Kernersville
-
Kinston, North Carolina, United States, 28501
- ECU Health Oncology Kinston
-
Mount Airy, North Carolina, United States, 27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro, North Carolina, United States, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Pinehurst, North Carolina, United States, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Richlands, North Carolina, United States, 28574
- ECU Health Oncology Richlands
-
Statesville, North Carolina, United States, 28625
- Novant Health Cancer Institute - Statesville
-
Thomasville, North Carolina, United States, 27360
- Novant Health Cancer Institute - Thomasville
-
Wilkesboro, North Carolina, United States, 28659
- Wake Forest Baptist Health - Wilkes Medical Center
-
Winston-Salem, North Carolina, United States, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, United States, 27103
- Novant Health Forsyth Medical Center
-
-
North Dakota
-
Bismarck, North Dakota, United States, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, United States, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, United States, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, United States, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, United States, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, United States, 58104
- Sanford Medical Center Fargo
-
Jamestown, North Dakota, United States, 58401
- Essentia Health - Jamestown Clinic
-
-
Ohio
-
Beavercreek, Ohio, United States, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, United States, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, United States, 44512
- Saint Elizabeth Boardman Hospital
-
Centerville, Ohio, United States, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, United States, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chardon, Ohio, United States, 44024
- Geauga Hospital
-
Chillicothe, Ohio, United States, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, United States, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, United States, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, United States, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, United States, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, United States, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, United States, 44106
- Case Western Reserve University
-
Cleveland, Ohio, United States, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, United States, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, United States, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, United States, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, United States, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, United States, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, United States, 43228
- Doctors Hospital
-
Columbus, Ohio, United States, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, United States, 43215
- Grant Medical Center
-
Columbus, Ohio, United States, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, United States, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, United States, 45409
- Miami Valley Hospital
-
Dayton, Ohio, United States, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, United States, 45428
- Dayton Veterans Affairs Medical Center
-
Dayton, Ohio, United States, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, United States, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, United States, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, United States, 43016
- Dublin Methodist Hospital
-
Findlay, Ohio, United States, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, United States, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, United States, 45840
- Orion Cancer Care
-
Franklin, Ohio, United States, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, United States, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, United States, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, United States, 45331
- Wayne Hospital
-
Greenville, Ohio, United States, 45331
- Dayton Physicians LLC-Wayne
-
Grove City, Ohio, United States, 43123
- Mount Carmel Grove City Hospital
-
Kettering, Ohio, United States, 45429
- Kettering Medical Center
-
Kettering, Ohio, United States, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, United States, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, United States, 43130
- Fairfield Medical Center
-
Lima, Ohio, United States, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, United States, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Mansfield, Ohio, United States, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, United States, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, United States, 43302
- OhioHealth Marion General Hospital
-
Mayfield Heights, Ohio, United States, 44124
- Hillcrest Hospital Cancer Center
-
Mentor, Ohio, United States, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, United States, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, United States, 43050
- Knox Community Hospital
-
Newark, Ohio, United States, 43055
- Licking Memorial Hospital
-
Newark, Ohio, United States, 43055
- Newark Radiation Oncology
-
Parma, Ohio, United States, 44129
- University Hospitals Parma Medical Center
-
Perrysburg, Ohio, United States, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, United States, 45662
- Southern Ohio Medical Center
-
Ravenna, Ohio, United States, 44266
- University Hospitals Portage Medical Center
-
Sandusky, Ohio, United States, 44870
- North Coast Cancer Care
-
Sandusky, Ohio, United States, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, United States, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, United States, 45504
- Springfield Regional Medical Center
-
Strongsville, Ohio, United States, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Toledo, Ohio, United States, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, United States, 43608
- Mercy Health - Saint Vincent Hospital
-
Troy, Ohio, United States, 45373
- Upper Valley Medical Center
-
Troy, Ohio, United States, 45373
- Dayton Physicians LLC - Troy
-
Wadsworth, Ohio, United States, 44281
- University Hospitals Sharon Health Center
-
Warren, Ohio, United States, 44484
- Saint Joseph Warren Hospital
-
Warrensville Heights, Ohio, United States, 44122
- South Pointe Hospital
-
Westerville, Ohio, United States, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, United States, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Wooster, Ohio, United States, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Wright-Patterson Air Force Base, Ohio, United States, 45433
- Wright-Patterson Medical Center
-
Youngstown, Ohio, United States, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, United States, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, United States, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, United States, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, United States, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, United States, 97701
- Saint Charles Health System
-
Clackamas, Oregon, United States, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, United States, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, United States, 97420
- Bay Area Hospital
-
Newberg, Oregon, United States, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, United States, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Portland, Oregon, United States, 97239
- Oregon Health and Science University
-
Portland, Oregon, United States, 97213
- Providence Portland Medical Center
-
Portland, Oregon, United States, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, United States, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Allentown, Pennsylvania, United States, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, United States, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Chadds Ford, Pennsylvania, United States, 19317
- Christiana Care Health System-Concord Health Center
-
Chambersburg, Pennsylvania, United States, 17201
- Chambersburg Hospital
-
Danville, Pennsylvania, United States, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, United States, 18301
- Pocono Medical Center
-
Ephrata, Pennsylvania, United States, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, United States, 17522
- Ephrata Community Hospital
-
Gettysburg, Pennsylvania, United States, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, United States, 17331
- WellSpan Medical Oncology and Hematology
-
Hazleton, Pennsylvania, United States, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, United States, 18201
- Lehigh Valley Hospital-Hazleton
-
Lebanon, Pennsylvania, United States, 17042
- Sechler Family Cancer Center
-
Lewisburg, Pennsylvania, United States, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, United States, 17044
- Lewistown Hospital
-
Pottsville, Pennsylvania, United States, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, United States, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, United States, 17870
- Geisinger Medical Oncology-Selinsgrove
-
State College, Pennsylvania, United States, 16801
- Geisinger Medical Group
-
Wilkes-Barre, Pennsylvania, United States, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
York, Pennsylvania, United States, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, United States, 17403
- WellSpan Health-York Hospital
-
-
Rhode Island
-
Westerly, Rhode Island, United States, 02891
- Smilow Cancer Hospital Care Center - Westerly
-
-
South Carolina
-
Bluffton, South Carolina, United States, 29910
- Saint Joseph's/Candler - Bluffton Campus
-
Boiling Springs, South Carolina, United States, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, United States, 29425
- Medical University of South Carolina
-
Clinton, South Carolina, United States, 29325
- Prisma Health Cancer Institute - Laurens
-
Easley, South Carolina, United States, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, United States, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, United States, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, United States, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, United States, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, United States, 29605
- BI-LO Charities Children's Cancer Center
-
Greenville, South Carolina, United States, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, United States, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, United States, 29651
- Gibbs Cancer Center-Pelham
-
Hilton Head Island, South Carolina, United States, 29926-3827
- South Carolina Cancer Specialists PC
-
Seneca, South Carolina, United States, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, United States, 29303
- Spartanburg Medical Center
-
Union, South Carolina, United States, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Aberdeen, South Dakota, United States, 57401
- Avera Cancer Institute-Aberdeen
-
Pierre, South Dakota, United States, 57501
- Avera Cancer Institute at Pierre
-
Sioux Falls, South Dakota, United States, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, United States, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, United States, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, United States, 37404
- Memorial Hospital
-
Cookeville, Tennessee, United States, 38501
- Cookeville Regional Medical Center
-
Hixson, Tennessee, United States, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Ooltewah, Tennessee, United States, 37363
- Memorial GYN Plus
-
-
Texas
-
Amarillo, Texas, United States, 79106
- The Don and Sybil Harrington Cancer Center
-
Bryan, Texas, United States, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, United States, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Edinburg, Texas, United States, 78539
- STCC at DHR Health Institute for Research and Development
-
Fort Worth, Texas, United States, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Richardson, Texas, United States, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Utah
-
American Fork, Utah, United States, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, United States, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, United States, 84321
- Logan Regional Hospital
-
Murray, Utah, United States, 84107
- Intermountain Medical Center
-
Ogden, Utah, United States, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, United States, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, United States, 84065
- Riverton Hospital
-
Salt Lake City, Utah, United States, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, United States, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, United States, 84143
- LDS Hospital
-
St. George, Utah, United States, 84770
- Saint George Regional Medical Center
-
-
Virginia
-
Charlottesville, Virginia, United States, 22908
- University of Virginia Cancer Center
-
Lynchburg, Virginia, United States, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Richmond, Virginia, United States, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, United States, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, United States, 23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen, Washington, United States, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, United States, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, United States, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, United States, 98004
- Overlake Medical Center
-
Bellingham, Washington, United States, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, United States, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, United States, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, United States, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, United States, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, United States, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, United States, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, United States, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, United States, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, United States, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, United States, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, United States, 99336
- Kadlec Clinic Hematology and Oncology
-
Kennewick, Washington, United States, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, United States, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, United States, 98499
- Saint Clare Hospital
-
Longview, Washington, United States, 98632
- PeaceHealth Saint John Medical Center
-
Lynnwood, Washington, United States, 98036
- Virginia Mason Lynnwood Medical Center
-
Port Townsend, Washington, United States, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, United States, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, United States, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, United States, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Renton, Washington, United States, 98055
- Valley Medical Center
-
Seattle, Washington, United States, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, United States, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, United States, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, United States, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, United States, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, United States, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, United States, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, United States, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, United States, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, United States, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, United States, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, United States, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, United States, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, United States, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, United States, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, United States, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, United States, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, United States, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, United States, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, United States, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, United States, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, United States, 98597
- Providence Regional Cancer System-Yelm
-
-
Wisconsin
-
Antigo, Wisconsin, United States, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, United States, 54911
- ThedaCare Regional Cancer Center
-
Appleton, Wisconsin, United States, 54915
- Ascension Saint Elizabeth Hospital
-
Ashland, Wisconsin, United States, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, United States, 54806
- Northwest Wisconsin Cancer Center
-
Brookfield, Wisconsin, United States, 53045
- Ascension Southeast Wisconsin Hospital - Elmbrook Campus
-
Burlington, Wisconsin, United States, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chilton, Wisconsin, United States, 53014
- Ascension Calumet Hospital
-
Eau Claire, Wisconsin, United States, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, United States, 54701
- HSHS Sacred Heart Hospital
-
Fond du Lac, Wisconsin, United States, 54937
- Aurora Health Center-Fond du Lac
-
Franklin, Wisconsin, United States, 53132
- Ascension Saint Francis - Reiman Cancer Center
-
Franklin, Wisconsin, United States, 53132
- Ascension Southeast Wisconsin Hospital - Franklin
-
Germantown, Wisconsin, United States, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, United States, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, United States, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, United States, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, United States, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Kenosha, Wisconsin, United States, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, United States, 54601
- Gundersen Lutheran Medical Center
-
La Crosse, Wisconsin, United States, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
Madison, Wisconsin, United States, 53705
- William S Middleton VA Medical Center
-
Madison, Wisconsin, United States, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, United States, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Manitowoc, Wisconsin, United States, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, United States, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, United States, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, United States, 54451
- Aspirus Medford Hospital
-
Mequon, Wisconsin, United States, 53097
- Ascension Columbia Saint Mary's Hospital Ozaukee
-
Milwaukee, Wisconsin, United States, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, United States, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, United States, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, United States, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, United States, 53210
- Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
-
Milwaukee, Wisconsin, United States, 53211
- Ascension Columbia Saint Mary's Hospital - Milwaukee
-
Milwaukee, Wisconsin, United States, 53215
- Ascension Saint Francis Hospital
-
Minocqua, Wisconsin, United States, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, United States, 53149
- ProHealth D N Greenwald Center
-
New Berlin, Wisconsin, United States, 53151
- Froedtert and MCW Moorland Reserve Health Center
-
New Richmond, Wisconsin, United States, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, United States, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, United States, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, United States, 54904
- Ascension Mercy Hospital
-
Oshkosh, Wisconsin, United States, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, United States, 53406
- Aurora Cancer Care-Racine
-
Racine, Wisconsin, United States, 53405
- Ascension All Saints Hospital
-
Rhinelander, Wisconsin, United States, 54501
- Aspirus Cancer Care - James Beck Cancer Center
-
Rice Lake, Wisconsin, United States, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, United States, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, United States, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, United States, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Stevens Point, Wisconsin, United States, 54481
- Aspirus Cancer Care - Stevens Point
-
Sturgeon Bay, Wisconsin, United States, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, United States, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, United States, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, United States, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, United States, 53188
- ProHealth Waukesha Memorial Hospital
-
Waupaca, Wisconsin, United States, 54981
- ThedaCare Cancer Care - Waupaca
-
Wausau, Wisconsin, United States, 54401
- Aspirus Regional Cancer Center
-
Wauwatosa, Wisconsin, United States, 53226
- Aurora Cancer Care-Milwaukee West
-
Wauwatosa, Wisconsin, United States, 53226
- Ascension Medical Group Southeast Wisconsin - Mayfair Road
-
West Allis, Wisconsin, United States, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, United States, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cheyenne, Wyoming, United States, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, United States, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, United States, 82801
- Welch Cancer Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
61 years and older (Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- PRE-REGISTRATION ELIGIBILITY CRITERIA (STEP 0)
- Patients must have been diagnosed with chronic lymphocytic leukemia (CLL) (> 5000 B-cells per uL of peripheral blood at any point during the course of their disease) or small lymphocytic lymphoma (SLL) with < 5000 B-cells per uL of blood but with disease-associated lymphadenopathy
- This blood submission is mandatory prior to registration/randomization to perform fluorescence in situ hybridization (FISH) centrally that will be used for stratification. It should be obtained as soon after pre-registration as possible
- REGISTRATION ELIGIBILITY CRITERIA (STEP 1)
Patients must be diagnosed with CLL or SLL in accordance with 2018 International Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria that includes all of the following:
- >= 5 x10^9 B lymphocytes (5000/uL) in the peripheral blood measured by flow cytometry at any point in the course of the disease or less peripheral blood involvement but disease-associated lymphadenopathy
- On local morphologic review, the leukemic cells must be small mature lymphocytes, and prolymphocytes must not exceed 55% of the blood lymphocytes
- Neoplastic cells on immunophenotype (performed locally) must reveal a clonal B-cell population, which express the B cell surface markers of CD19 and CD20, as well as the T-cell antigen CD5. Patients with bright surface immunoglobulin expression or lack of CD23 expression in >10% of cells must lack t(11;14) translocation by interphase cytogenetics
Patients must be intermediate or high-risk Rai stage CLL or SLL
- Intermediate risk (formerly stage I/II) is defined by lymphadenopathy and/or hepatomegaly or splenomegaly without anemia or thrombocytopenia
- High risk (formerly stage III/IV) is defined by splenomegaly and/or anemia (hemoglobin < 11g/dL) not attributable to autoimmune hemolytic anemia and/or thrombocytopenia (platelets [plt] < 100 x10^9/L) not attributable to autoimmune thrombocytopenia
Patients must meet criteria for treatment as defined by 2018 IWCLL guidelines which includes at least one of the following criteria:
- Evidence of marrow failure as manifested by the development or worsening of anemia or thrombocytopenia (not attributable to autoimmune hemolytic anemia or thrombocytopenia)
- Massive (>= 6 cm below the costal margin), progressive or symptomatic splenomegaly
- Massive nodes (>= 10 cm) or progressive or symptomatic lymphadenopathy
- Progressive lymphocytosis with a lymphocyte doubling time < 6 months or an increase of >= 50% over a 2 month period
- Autoimmune anemia and/or thrombocytopenia that is poorly responsive to standard therapy
- Symptomatic or functional extranodal involvement (e.g. skin, kidney, lung, spine)
Constitutional symptoms, which include any of the following:
- Unintentional weight loss of 10% or more within 6 months
- Significant fatigue
- Fevers > 100.5 degrees Fahrenheit (F) for 2 weeks or more without evidence of infection
- Night sweats >= 1 month without evidence of infection
- Treatment with rituximab and/or high dose corticosteroids for autoimmune complications of CLL/SLL must be complete at least 4 weeks prior to enrollment. Palliative steroids must be at a dose not higher than 20 mg/day of prednisone or equivalent corticosteroid at the time of registration
- Age >= 65 years
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Absolute neutrophil count (ANC) >= 1,000/mm^3 except if due to bone marrow involvement
- Platelet count (untransfused) >= 30,000/mm^3 except if due to bone marrow involvement
- Calculated (Calc.) creatinine clearance >= 40 mL/min (by Cockcroft-Gault)
- Bilirubin =< 1.5 x upper limit of normal (ULN) except if due to liver involvement, hemolysis, or Gilbert's disease
- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) except if due to liver involvement
- If evidence of chronic hepatitis B virus (HBV) infection, HBV viral load must be undetectable on suppressive therapy if indicated
- Please note: Intravenous immunoglobulin therapy (IVIG) can cause a false positive hepatitis B serology. If patients receiving routine IVIG have core antibody or surface antigen positivity without evidence of active viremia (negative hepatitis B deoxyribonucleic acid [DNA]) they may still participate in the study, must have hepatitis serologies and hepatitis B DNA monitored periodically by the treating physician
- If history of hepatitis C virus (HCV) infection, must be treated with undetectable HCV viral load
- Human immunodeficiency virus (HIV)-infected patients on effective antiretroviral therapy with undetectable viral load within 6 months are eligible for this trial
- Central fluorescent in situ hybridization (FISH) blood results are mandatory prior to registration/randomization for it will be used for stratification
- Patients must be able to swallow capsules and not have the following conditions: disease significantly affecting gastrointestinal absorption, resection of the stomach or small bowel, partial or complete bowel obstruction
- Patients must be able to receive either a xanthine oxidase inhibitor or rasburicase for prophylaxis/treatment of tumor lysis syndrome (TLS)
- RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2)
- Completion of treatment through cycle 14 day 28, and remain on ibrutinib therapy
- Receipt of central BM MRD results
- Response assessment completed with CR determination
Exclusion Criteria:
- Patients must not have had prior therapy for CLL/SLL (except palliative steroids or treatment of autoimmune complications of CLL with rituximab or steroids)
- Patients must not have any history of Richter's transformation or prolymphocytic leukemia (prolymphocytes in blood > 55%)
- Patients with class III or class IV heart failure by New York Heart Association, those with unstable angina, and those with uncontrolled arrhythmia are not eligible
- Patients who have had a myocardial infarction, intracranial bleed, or stroke within the past 6 months are not eligible
- Patients must not be receiving active systemic anticoagulation with heparin or warfarin. Patients on warfarin must discontinue the drug for at least 10 days prior to registration on the study
- Chronic concomitant treatment with strong inhibitors of CYP3A4/5 is not allowed on this study. Patients on strong CYP3A inhibitors must discontinue the drug for 14 days prior to registration on the study
- Chronic concomitant treatment with strong CYP3A4/5 inducers is not allowed. Patients must discontinue the drug 14 days prior to registration on the study
- Patients must not require more than 20 mg prednisone or equivalent corticosteroid daily
- Patients must not have uncontrolled active systemic infection requiring intravenous antibiotics
- Patients must not have a known allergy to mannitol
- Patients must not have prior significant hypersensitivity to rituximab (not including infusion reactions)
- Patients may not have had major surgery within 10 days prior to registration, or minor surgery within 7 days prior to registration. Examples of minor surgery include dental surgery, insertion of a venous access device, skin biopsy, or aspiration for a joint. The decision about whether a surgery is major or minor can be made at the discretion of the treating physician
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Active Comparator: Arm I (ibrutinib, obinutuzumab)
Patients receive ibrutinib PO QD on days 1-28.
Patients also receive obinutuzumab IV on days 1, 2, 8, and 15 of cycle 1, and on day 1 of cycles 2-6.
Treatment repeats every 28 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity.
Beginning cycle 15, patients receive ibrutinib PO QD every 28 days in the absence of disease progression or unacceptable toxicity.
|
Given PO
Other Names:
Given IV
Other Names:
|
|
Experimental: Arm II (ibrutinib, obinutuzumab, venetoclax)
Patients receive ibrutinib PO QD on days 1-28.
Patients also receive obinutuzumab IV on days 1, 2, 8, and 15 of cycle 1, and on day 1 of cycles 2-6.
Beginning cycle 3, patients also receive venetoclax PO QD on days 1-28.
Treatment repeats every 28 days for 14 cycles in the absence of disease progression or unacceptable toxicity.
All patients will then receive a 15th cycle of ibrutinib.
Beginning cycle 16, patients who do not achieve a BM MRD negative CR, receive ibrutinib PO QD every 28 days in the absence of disease progression or unacceptable toxicity.
Patients who achieve a BM MRD negative CR undergo observation every 3 cycles for 6 years, then every 6 cycles thereafter.
|
Given PO
Other Names:
Given PO
Other Names:
Given IV
Other Names:
Undergo observation
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Progression-free Survival (PFS)
Time Frame: 5 years
|
PFS will be compared between the experimental and control treatment strategy groups using a stratified log-rank test (stratified on Rai stage, intermediate versus [vs.] high, and del(17p13.1)
by fluorescence in situ hybridization [FISH], present vs. absent).
The Kaplan-Meier method will be used to estimate PFS distributions.
Five-year PFS estimates and corresponding hazard ratios will be provided with 95% confidence intervals for each treatment strategy.
|
5 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Bone Marrow (BM) Minimal Residual Disease (MRD)- Complete Response (CR) Rate
Time Frame: Up to 10 years
|
BM MRD- CR rate will be calculated and will be estimated using the number of patients meeting the BM MRD- CR criteria divided by the total number of patients randomized to each of the treatment arms.
The stratified Cochran-Mantel-Haenszel test will be used to compare the BM MRD- CR rates between treatment arms (stratified on Rai stage, intermediate vs. high, and del(17p13.1)
by FISH, present vs. absent).
|
Up to 10 years
|
|
Overall Survival (OS)
Time Frame: From randomization date until death from any cause, assessed up to 10 years
|
The Kaplan-Meier method will be used to estimate the OS distribution for each treatment strategy.
Estimates at 5 years will be calculated with corresponding 95% confidence intervals, and differences in these estimates between the treatment strategies will be tested using a stratified chi-square test based on the complementary log-log transformation of the Kaplan-Meier estimates.
Comparisons in OS curves between experimental and control treatment strategies will use a stratified log-rank test (stratified on Rai stage, intermediate vs. high, and del(17p13.1)
by FISH, present vs. absent).
Hazard ratios with 95% confidence intervals will be estimated from the corresponding, stratified proportional hazard model.
|
From randomization date until death from any cause, assessed up to 10 years
|
|
Incidence of Adverse Events
Time Frame: Up to 10 years
|
Will be defined as adverse events that are classified as either possibly, probably, or definitely related to study treatment, graded per National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0.
Frequency and severity of adverse events and tolerability for each treatment strategy group will be summarized using descriptive statistics.
The maximum grade for each type of toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns.
The incidence of severe (grade 3+) adverse events or toxicities will be described.
|
Up to 10 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Jennifer A Woyach, Alliance for Clinical Trials in Oncology
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 31, 2019
Primary Completion (Actual)
January 17, 2025
Study Completion (Estimated)
December 29, 2026
Study Registration Dates
First Submitted
November 9, 2018
First Submitted That Met QC Criteria
November 9, 2018
First Posted (Actual)
November 13, 2018
Study Record Updates
Last Update Posted (Actual)
May 29, 2026
Last Update Submitted That Met QC Criteria
May 28, 2026
Last Verified
January 1, 2026
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Neoplasms
- Chronic Disease
- Disease Attributes
- Immune System Diseases
- Neoplasms by Histologic Type
- Hematologic Diseases
- Lymphatic Diseases
- Lymphoproliferative Disorders
- Immunoproliferative Disorders
- Leukemia, B-Cell
- Leukemia, Lymphoid
- Leukemia
- Pathological Conditions, Signs and Symptoms
- Hemic and Lymphatic Diseases
- Leukemia, Lymphocytic, Chronic, B-Cell
- Investigative Techniques
- Methods
- Observation
- venetoclax
- obinutuzumab
- ibrutinib
Other Study ID Numbers
- NCI-2018-02485 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180821 (U.S. NIH Grant/Contract)
- A041702 (Other Identifier: CTEP)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
YES
IPD Plan Description
NCI is committed to sharing data in accordance with NIH policy.
For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Yes
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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