Changes in Brain Tissue Pulsatility With Musical Stimuli (M-PULSE)

Music Perception is well known to elicit emotions and neuronal activations. Changes in the cerebrovascular physiology have also been found in emotional tasks but only few studies have investigated markers of cerebrovascular physiology in a music task and no study has used the Ultrasound method of Tissue Pulsatility Imaging (TPI) in a music task. The use of TPI to measure reactivity of Brain Tissue Pulsatility Imaging (BTP) could further elucidate the cerebral basis of music perception.

Study Overview

• Status: Completed
• Conditions: Healthy

• Study Type: Observational
• Enrollment (Actual): 25

Contacts and Locations

Study Locations

• France
  • Tours, France, 37044
    • DESMIDT

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Healthy volunteers

Description

Inclusion Criteria:

• more or equal 18 years-old and less or equal 45 years-old
• no known hearing problem

Exclusion Criteria:

• professional musician
• history of neurologic, psychiatric or cadiologic disease
• treatment which could impact parameters of brain tissue pulsatility and peripheral nervous system
• opposition to use the data

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
amplitude of variations in brain tissue pulsatility	in micrometers	Baseline

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
heart rate	beat by minute	Baseline
breathing rate	Frequency	Baseline
skin conductance	in milliVolt	Baseline
score of barcelona music reward questionnary (BMQR)	BMQR: Barcellona Music Reward Questionnaire for the evaluation of musical anhedonia; Only the total score of musical reward will be reported; for total score, minimum value is 20, maximum value is 100. Values under 40 represent low values in the overall score; values above 60 indicate high values in the overall score;; High global score (>60) represents a better outcome; low global score (<40) represents a worse outcome, notably an impairment in music reward processing;; The overall score is computed by adding raw scores of the items (except for items 2 and 5, which need to be reversed).	Baseline

Collaborators and Investigators

• Sponsor: University Hospital, Tours

Study record dates

Study Major Dates

• Study Start (Actual): April 2, 2019
• Primary Completion (Actual): April 26, 2019
• Study Completion (Actual): April 26, 2019

Study Registration Dates

• First Submitted: March 4, 2019
• First Submitted That Met QC Criteria: March 5, 2019
• First Posted (Actual): March 8, 2019

Study Record Updates

• Last Update Posted (Actual): August 21, 2019
• Last Update Submitted That Met QC Criteria: August 20, 2019
• Last Verified: August 1, 2019

More Information

Terms related to this study

• Other Study ID Numbers: RIPH3-RNI19-M-PULSE

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No