The Relationship Between Urine Iodine, Urine Bisphenol A and Autoimmune Thyroid Disease in Reproductive Women

Autoimmune thyroid disease (AITD) is the main cause of hypothyroidism in reproduction women, iodine and bisphenol A are the environmental factors for AITD. The research was mainly designed to investigate the effect of iodine and BPA on AITD in reproduction women to provide new evidence for hypothyroidism in reproduction women.

Study Overview

• Status: Unknown
• Conditions: The Effect of Iodine and BPA on AITD in Reproduction Women
• Intervention / Treatment: Other: urinary iodine and urine BPA

Detailed Description

71 patients with thyroid autoantibody positive were treated as AITD group, another 71 healthy reproduction women were selected as normal group. Women age, BMI, thyroid disease history, family history, marital and reproductive history, whether the application of iodized salt, thyroid function and thyroid autoantibodies detection were recorded. Meanwhile urine iodine, urinary iodine/urinary creatinine, urine BPA and urinary BPA/creatinine were tested. The urine iodine and BPA levels of the two groups were compared. Taking AITD as the dependent variable, logistic regression was conducted to analyze whether urinary iodine and BPA were risk factors of AITD.

• Study Type: Observational
• Enrollment (Anticipated): 142

Contacts and Locations

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 102206
      • Recruiting
      • Peking University International Hospital
      • Contact: jun zhao; Phone Number: +8601069006708; Email: zhaojun@pkuih.edu.cn

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

• Sampling Method: Non-Probability Sample

Study Population

In Peking University international hospital women of childbearing age (age 20 to 45 years old) of 142 cases of 71 patients with thyroid autoantibodies positive as AITD group, the other selected 71 cases of healthy women of childbearing age as normal group, record the age, BMI, and examination of the history of history of thyroid disease, family history and whether the application of iodized salt and other general information and we, thyroid autoantibodies detection results, urine iodine, urinary iodine/urinary creatinine and urinary BPA and urinary BPA/creatinine detection.

Description

Inclusion Criteria:

1. AITD group: positive thyroid autoantibody (one thyroid autoantibody), normal thyroid function.
2. Normal group: thyroid autoantibody negative, normal thyroid function.
3. No previous history of hyperthyroidism or hypothyroidism, no history of thyroid surgery or I131 radiotherapy, and no thyroid hormone or anti-thyroid drugs were used.

Exclusion Criteria:

1. Patients with severe liver, kidney, heart and other important organ failure.
2. Merger with other autoimmune diseases.
3. Amiodarone, iodine contrast agent and other drugs affecting thyroid function are used.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
AITD group; Thyroid antibody positive and hypothyroidism	Other: urinary iodine and urine BPA; urinary iodine and urine BPA
normal group; Thyroid antibody negative and hypothyroidism	Other: urinary iodine and urine BPA; urinary iodine and urine BPA

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Comparison of urinary iodine levels between the two groups	Urinary iodine levels were compared between patients with autoimmune thyroid disease and normal women.	2019-2011
Comparison of urinary BPA levels between the two groups	Urinary BPA levels were compared between patients with autoimmune thyroid disease and normal women.	2019-2011

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Influencing factors of autoimmune thyroid diseases.	Abnormal levels of iodine and PBA are influential factors in autoimmune thyroid disease.	2019-2012

Collaborators and Investigators

• Sponsor: Xiaomei Zhang

Study record dates

Study Major Dates

• Study Start (Actual): June 24, 2019
• Primary Completion (Anticipated): October 1, 2022
• Study Completion (Anticipated): October 1, 2022

Study Registration Dates

• First Submitted: April 24, 2019
• First Submitted That Met QC Criteria: April 29, 2019
• First Posted (Actual): April 30, 2019

Study Record Updates

• Last Update Posted (Actual): March 6, 2020
• Last Update Submitted That Met QC Criteria: March 4, 2020
• Last Verified: March 1, 2020

More Information

Terms related to this study

• Keywords: iodine; autoimmune thyroid disease; bisphenol A
• Additional Relevant MeSH Terms: Endocrine System Diseases; Thyroid Diseases
• Other Study ID Numbers: Peking UIH

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: Urinary iodine and bisphenol A may affect AITD in reproduction women.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No