Periodontitis and Atherosclerotic-related Arterial Stenosis

The Relationship Between Periodontitis and Atherosclerotic-related Arterial Stenosis in the Chinese Population

This study aimed to evaluate the association between periodontitis and atherosclerosis of the cerebral vasculature in the Chinese population.

Study Overview

• Status: Unknown
• Conditions: Atherosclerosis of Artery

Detailed Description

Periodontitis has been demonstrated as a risk factor for ischaemic stroke in several clinical studies. Atherosclerosis of the cerebral vasculatureis an important pathological process causing ischaemic stroke. The investigator's study aims to investigate the relationship between tooth loss(used as a surrogate of periodontal disease) and atherosclerotic-related arterial stenosis in the Chinese population. An estimated 1,000 participants that underwent cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine between Apirl 2020 and January 2022 will be recruited in this trial. Arterial stenosis features of each participants will be collected based on the results of digital subtraction angiography (DSA). The missing teeth counts of each participant will be collected and some of them will recieved comprehensive periodontal examination. Besides, blood samples will be collected in order to investigate the serum inflammatory markers(CRP,WBC,albumin,IL-6,IL-10). The relationship between tooth loss and atherosclerotic-related arterial stenosis will be analysed by regression models adjusted for conventional risk factors (sex,age, obesity,smoking,Alcohol drinking,diabetes,hypertension,hyperuricaemia,hyperhomocysteinaemia)

• Study Type: Observational
• Enrollment (Anticipated): 1000

Contacts and Locations

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 98 years (Adult, Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Study population are people who underwent cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine from April 2020 to April 2022 and meat the inclusion and exclusion criteria

Description

Inclusion Criteria:

1. subjects who underwent cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine from April 2020 to December 2021
2. subjects who voluntarily participated in this study and provided informed consent.

Exclusion Criteria:

1. intracranial and extracranial artery stenosis caused by vascular inflammation, systemic connective tissue disease, and muscle fibre structure hypoplasia
2. inability to cooperate with the investigation
3. intracranial aneurysm and cerebral arteriovenous malformation confirmed by cerebral angiography
4. receipt of periodontal treatment in the previous 24 months.

Study Plan

How is the study designed?

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort
0-9 missing teeth; participants with 0-9 missing teeth
10-19 missing teeth; participants with 10-19 missing teeth
23-31 missing teeth; participants with 23-31 missing teeth
Edentulous; participants with no teeth

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The relationship between atherosclerotic-related stenosis in different brain arteries and tooth loss categories	The arteries of the brains will be partitioned into the following segments: common carotid artery (CCA), internal carotid arteries (ICA, C1-C7), the external carotid artery (ECA), the anterior cerebral artery (ACA, A1-A2), the middle cerebral artery (MCA, M1-M2), the posterior cerebral artery (PCA), the basilar artery (BA), the vertebral artery (VA,V1-V4) and the subclavicular artery (SUB) .The chi-square test and Fisher's exact test will be used, as appropriate, to estimate the relationship between tooth loss and stenosis distributed in different branches	1 day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The relationship between the severity of artery stenosis and tooth loss categories	The degree of vascular stenosis will be categorized into five group: no stenosis, mild stenosis, moderate stenosis, severe stenosis and occlusion. Ordinal logistic regression will be performed to analyse the relationship between the tooth loss categories and the degrees of artery stenosis.	1 day

Collaborators and Investigators

• Sponsor: Guangzhou University of Traditional Chinese Medicine

Study record dates

Study Major Dates

• Study Start (Anticipated): April 1, 2020
• Primary Completion (Anticipated): March 1, 2022
• Study Completion (Anticipated): April 1, 2022

Study Registration Dates

• First Submitted: March 8, 2020
• First Submitted That Met QC Criteria: March 10, 2020
• First Posted (Actual): March 11, 2020

Study Record Updates

• Last Update Posted (Actual): March 11, 2020
• Last Update Submitted That Met QC Criteria: March 10, 2020
• Last Verified: March 1, 2020

More Information

Terms related to this study

• Keywords: risk factors; atherosclerosis; periodontitis; arterial stenosis
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Pathological Conditions, Anatomical; Periodontitis; Constriction, Pathologic; Atherosclerosis
• Other Study ID Numbers: ZF2019-010

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No