- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04467658
Neurophysiological Marker of ADHD in Children
February 16, 2024 updated by: Junwon Kim, Daegu Catholic University Medical Center
Neurophysiological Marker of Attention Deficit Hyperactivity Disorder in Children
This study investigated quantitative electroencephalography (QEEG) subtypes as auxiliary tools to assess Attention Deficit Hyperactivity Disorder (ADHD).
Patient assessed using the Korean version of the Diagnostic Interview Schedule for Children Version IV and were assigned to one of three groups: ADHD, ADHD-Not Otherwise specified (NOS), and Neurotypical (NT).
The investigators measure absolute and relative EEG power in 19 channels and conducted an auditory continuous performance test.
The investigators analyzed QEEG according to the frequency range: delta (1-4 Hz), theta (4-8 Hz), slow alpha (8-10 Hz), fast alpha (10-13.5 Hz), and beta (13.5-30
Hz).
The subjects were then grouped by Ward's method of cluster analysis using the squared Euclidian distance to measure dissimilarities.
Study Overview
Status
Completed
Intervention / Treatment
- Diagnostic test: electroencephalography absolute delta power
- Diagnostic test: electroencephalography relative delta power
- Diagnostic test: electroencephalography absolute theta power
- Diagnostic test: electroencephalography relative theta power
- Diagnostic test: electroencephalography absolute slow alpha power
- Diagnostic test: electroencephalography relative slow alpha power
- Diagnostic test: electroencephalography absolute fast alpha power
- Diagnostic test: electroencephalography relative fast alpha power
- Diagnostic test: electroencephalography absolute beta power
- Diagnostic test: electroencephalography relative beta power
- Diagnostic test: Korean ADHD rating scale
- Diagnostic test: Korean Version of Diagnostic Interview Schedule for Children Version IV
Detailed Description
Participants between 7 and 12 years of age diagnosed with ADHD according to the DSM-5 criteria were included in the study.
The ADHD diagnosis was based on a Korean version of the Diagnostic Interview Schedule for Children Version IV (DISC-IV), which is a structured interview tool, and these diagnoses were confirmed by multiple child and adolescent psychiatrists.
If participants did not meet the ADHD diagnostic criteria of DSM-IV and DISC-IV, they were assigned to the Neurotypical (NT) group.
Based on the results of the DISC-IV test, participants were assigned to the ADHD or Non-Other Specified (NOS) group.
Patients who met the diagnostic criteria of ADHD in DSM-IV, but whose score did not exceed six, and had a score of more than three in the attention deficit or hyperactivity/impactivity scale of DISC-IV were included in the NOS group.
Children with a history of brain damage, neurological disorders, genetic disorders, substance dependence, epilepsy, or any other mental disorder were excluded from participation.
Children with an IQ of 70 or lower according to the Korean-Wechsler Intelligence Scale for Children (Fourth Edition) or who were receiving drug treatment were also excluded from this study.
The EEG recordings were performed using a SynAmps2 direct-current (DC) amplifier and a 10-20 layout 64-channel Quick-Cap electrode-placement system (Neuroscan Inc., NC, USA).
The EEG data were digitally recorded from 19 gold cup electrodes placed according to the international 10-20 system.
The impedances were maintained below 5 kΩ, and the sampling rate was 1000 Hz.
The investigators use the linked mastoid reference and two additional bipolar electrodes to measure horizontal and vertical eye movements.
During the recording, each participant laid in a dimly lit, electrically shielded, sound-attenuated room.
Resting EEG recordings were recorded after three minutes with the participants' eyes closed.
Study Type
Observational
Enrollment (Actual)
140
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Jun Won Kim, M.D. Ph.D.
- Phone Number: +82-53-630-4780
- Email: f_affection@naver.com
Study Locations
-
-
Nam-gu
-
Daegu, Nam-gu, Korea, Republic of, 42471
- Daegu Catholic University Medical Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
5 years to 10 years (Child)
Accepts Healthy Volunteers
Yes
Sampling Method
Probability Sample
Study Population
Patients who suspected attention-deficit/hyperactivity disorder conducted QEEG and diagnosed with DISC-IV
Description
Inclusion Criteria:
- Participants between 7 and 12 years of age diagnosed with ADHD according to the DSM-5 criteria were included in the study
Exclusion Criteria:
- Children with a history of brain damage, neurological disorders, genetic disorders, substance dependence, epilepsy, or any other mental disorder were excluded from participation.
- Children with an IQ of 70 or lower according to the Korean-Wechsler Intelligence Scale for Children (Fourth Edition) or who were receiving drug treatment were also excluded from this study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Only
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
ADHD
|
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
The KARS is a standardized screening tool for ADHD in Korean children and rating scale completed by the parents.
The DISC-IV is a structured diagnostic tool that was developed for use in epidemiological studies in children and adolescents
|
NT NeuroTypical
|
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
The KARS is a standardized screening tool for ADHD in Korean children and rating scale completed by the parents.
The DISC-IV is a structured diagnostic tool that was developed for use in epidemiological studies in children and adolescents
|
ADHD NOS
|
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
We used MATLAB 7.0.1 (Math Works, Natick, MA, USA) and the EEGLAB toolbox to pre-process and analyze the EEG recordings.
First, the EEG data were down-sampled to 250 Hz.
Next, the EEG data were detrended and mean-subtracted to remove the DC component.
A 1-Hz high-pass filter and a 60-Hz notch filter were applied to remove eye and electrical noise.
Next, independent component analysis (ICA) was performed to remove the well-defined sources of artifacts.
ICA has been shown to reliably isolate artifacts caused by eye and muscle movements and heart noise (23).
Finally, clinical psychiatrists and EEG experts visually inspected the corrected EEGs.
For the analysis, we selected more than two minutes of artifact-free EEG readings from the three-minute recordings
The KARS is a standardized screening tool for ADHD in Korean children and rating scale completed by the parents.
The DISC-IV is a structured diagnostic tool that was developed for use in epidemiological studies in children and adolescents
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
QEEG topographical plots of the results of the statistical comparisons to normative values (z-scores) using Neuroguide software
Time Frame: through study completion, an average of 1 year
|
The investigators measures QEEG on first outpatient clinic and conduct topography for mapping
|
through study completion, an average of 1 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 8, 2018
Primary Completion (Actual)
February 28, 2021
Study Completion (Actual)
February 28, 2021
Study Registration Dates
First Submitted
July 1, 2020
First Submitted That Met QC Criteria
July 8, 2020
First Posted (Actual)
July 13, 2020
Study Record Updates
Last Update Posted (Actual)
February 20, 2024
Last Update Submitted That Met QC Criteria
February 16, 2024
Last Verified
February 1, 2024
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- CR-18-096
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
IPD Plan Description
Data will be shared on request for proper reason
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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Corium, Inc.Premier Research Group plc; Almac; Prometrika, LLCRecruitingAttention Deficit/Hyperactivity DisorderUnited States
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Massachusetts General HospitalShire Human Genetic Therapies, Inc.Active, not recruitingAttention Deficit/Hyperactivity DisorderUnited States
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Ataturk UniversityCompletedAttention-deficit/Hyperactivity DisorderTurkey
Clinical Trials on electroencephalography absolute delta power
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SanofiCompletedType 2 DiabetesUnited States, Canada, Chile, Czech Republic, Estonia, France, Germany, Hungary, Italy, Latvia, Lithuania, Mexico, Poland, Romania, Russian Federation, Spain, Ukraine, United Kingdom