Giant Cell Arteritis and Differential Diagnoses Associated With Positive Temporal Artery Biopsy

Giant Cell Arteritis and Differential Diagnoses Associated With Positive Temporal Artery Biopsy: a Monocentric Retrospective Study

Temporal artery biopsy is a useful tool helping to the diagnosis of giant cell arteritis. However, other diagnoses might be associated with abnormal temporal artery biopsy. The purpose of this study is to describe the frequency of giant cell arteritis differential diagnoses with positive temporal artery biopsy.

Study Overview

• Status: Completed
• Conditions: Vasculitis; Giant Cell Arteritis
• Intervention / Treatment: Diagnostic test: temporal artery biopsy

• Study Type: Observational
• Enrollment (Actual): 114

Contacts and Locations

• Study Contact: Name: Thomas Moulinet, MD; Phone Number: +33 3 83 15 53 04; Email: t.moulinet@chru-nancy.fr

Study Locations

• France
  • Lorraine
    • Nancy, Lorraine, France, 54500
      • Nancy University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

all patients with significant inflammation on temporal artery biospy, with a final diagnosis of giant cell arteritis or an other diagnosis.

Description

Inclusion Criteria:

• positive artery biopsy between january 1st 2000 and july 25th 2019

Exclusion Criteria:

• orther vascular biopsy than temporal artery biospy

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
positive temporal artery biopsy; all adult patients with significant inflammation shown on temporal artery biopsy	Diagnostic test: temporal artery biopsy; description of temporal artery biopsy features, and its correlation with diagnosis of giant cell arteritis or other differential diagnoses.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
percentage of giant cell arteritis and differential diagnoses	baseline

Collaborators and Investigators

• Sponsor: Central Hospital, Nancy, France

Publications and helpful links

General Publications

• Pontille F, Decker P, Gauchotte G, Jaussaud R, Moulinet T. Diagnoses associated with temporal arteritis. Eur J Intern Med. 2023 Aug 14:S0953-6205(23)00295-9. doi: 10.1016/j.ejim.2023.08.010. Online ahead of print. No abstract available.

Study record dates

Study Major Dates

• Study Start (Actual): August 1, 2020
• Primary Completion (Actual): March 30, 2021
• Study Completion (Actual): December 30, 2022

Study Registration Dates

• First Submitted: September 14, 2020
• First Submitted That Met QC Criteria: September 14, 2020
• First Posted (Actual): September 18, 2020

Study Record Updates

• Last Update Posted (Actual): October 24, 2023
• Last Update Submitted That Met QC Criteria: October 23, 2023
• Last Verified: October 1, 2023

More Information

Terms related to this study

• Keywords: vasculitis; giant cell arteritis; temporal artery biopsy
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Skin Diseases; Immune System Diseases; Autoimmune Diseases of the Nervous System; Autoimmune Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Muscular Diseases; Skin Diseases, Vascular; Vasculitis, Central Nervous System; Polymyalgia Rheumatica; Giant Cell Arteritis; Arteritis; Vasculitis
• Other Study ID Numbers: 2020PI061

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No