- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04558255
A Preliminary Study on the Detection of Plasma Markers in Early Diagnosis for Lung Cancer
Plasma Biomarkers as a Non-invasive Approach for Early Diagnosis of Lung Cancer
Lung cancer is the most common cancer with the highest morbidity and mortality in the world. Stagement is closely related to the 5 years of survival rate of patients. The postoperative 5-year survival rate is above 90% for stage ⅠA lung cancer patients, while the 5-year survival rate of stage IV lung cancer patients is less than 5%. Therefore, early screening and diagnosis for lung cancer is a key method to reduce lung cancer mortality and prolong survival for patients.
At present, low-dose computed tomography (LDCT) is the most effective method for early detection of lung cancer. In addition to imaging examination, plasma tumor markers detection is also a common clinical detection method for tumor screening and postoperative monitoring.
Liquid biopsy is a non-invasive or minimally invasive method for testing blood or other liquid samples to analyze tumor-related markers including nucleic acids and proteins. Several studies have explored the detection of hot spot gene mutations, methylation and methylation changes of DNA, protein markers and autoantibodies in peripheral blood in lung cancer patients. Liquid biopsy has generally become the most popular field for early diagnosis of lung cancer.
Based above, it is necessary to combine multi-omics methods to improve the detection of early stage lung cancer. In our study, we intend to integrate molecular features obtained through liquid biopsy and clinical data of lung cancer patients, and develop and prospectively validate a machine-learning method which can robustly discriminate early-stage lung cancer patients from controls.
Study Overview
Status
Conditions
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Kezhong Chen, M.D.
- Phone Number: +8613488752289
- Email: mdkzchen@163.com
Study Locations
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Beijing
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Beijing, Beijing, China, 100044
- Recruiting
- Peking University People's Hospital
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Contact:
- Chen Kezhong, M.D.
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Enrolled patients are newly diagnosed patients
- In patients diagnosed as pulmonary nodules by imaging, benign and malignant conditions of the nodules are determined by postoperative pathology after surgical resection
- There is clear cancer stage information
- In addition to pulmonary nodules, there are no suspicious nodules of other organs
- No previous history of malignant tumor
Exclusion Criteria:
- Patients with a history of malignant tumor
- Patients with suspectednodules in other parts of the body at the time of diagnosis
- Patients who have previously received surgery, chemotherapy or radiotherapy for pulmonary lesions
- Patients with severe blood lipid in peripheral blood extracted which affects subsequent detection
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Rates of malignant and benign pulmonary nodules measured by the postoperative pathology
Time Frame: 5 days after the surgery
|
After the sugery of each patients with pulmonary nodules, we will get the clinicopathologic characteristics of the patients.
Tumor stage and grade will be evaluated by us and rates of malignant and benign pulmonary nodules will be the primary outcome which we follow.
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5 days after the surgery
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Collaborators and Investigators
Investigators
- Study Director: Jun Wang, M.D., Peking University People's Hospital
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- PTHO1903
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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